8-(5-Chloropentoxy)-2-methylquinoline | 1094693-78-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-(5-Chloropentoxy)-2-methylquinoline
• CAS: 1094693-78-3
• 化学式: C₁₅H₁₈ClNO
• mdl: MFCD11549265
• 分子量: 263.767
• InChiKey: JMQSJMKQEINLGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  8-羟基喹哪啶 、 1,5-二氯戊烷 在 sodium hydroxide 、 四丁基溴化铵 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 48.0h， 以40%的产率得到1,5-bis[(2-methyl-8-quinolyl)oxy]pentane
  参考文献：
  名称：

  Facile synthesis of seven to nine-membered-fused tricyclic quinolones and quinolinium salts under phase transfer catalyzed conditions

  摘要：

  Phase transfer catalyzed one-pot syntheses of fused oxazepino, oxazocino, and oxazonino quinolinium cations and quinolones were achieved from 8-hydroxy quinoline derivatives with 1,omega-dihaloalkanes. Structures of all the products were elucidated by spectroscopic analysis. Single crystal X-ray crystallographic analysis of three compounds and graphical superposition of the structures indicate that products having seven-membered ring are less planar compared to the product having eight-membered ring. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.048

文献信息

• Facile synthesis of seven to nine-membered-fused tricyclic quinolones and quinolinium salts under phase transfer catalyzed conditions
  作者：Priyankar Paira、Abhijit Hazra、Krishnendu B. Sahu、Sukdeb Banerjee、Nirup B. Mondal、Niranjan P. Sahu、Manuela Weber、Peter Luger

  DOI：10.1016/j.tet.2008.02.048

  日期：2008.4

  Phase transfer catalyzed one-pot syntheses of fused oxazepino, oxazocino, and oxazonino quinolinium cations and quinolones were achieved from 8-hydroxy quinoline derivatives with 1,omega-dihaloalkanes. Structures of all the products were elucidated by spectroscopic analysis. Single crystal X-ray crystallographic analysis of three compounds and graphical superposition of the structures indicate that products having seven-membered ring are less planar compared to the product having eight-membered ring. (c) 2008 Elsevier Ltd. All rights reserved.