methyl 6-S-acetyl-2,3,4-tri-O-benzyl-6-deoxy-β-D-allopyranoside | 1261294-43-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 6-S-acetyl-2,3,4-tri-O-benzyl-6-deoxy-β-D-allopyranoside
• 英文别名: S-[[(2S,3S,4R,5R,6R)-6-methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl] ethanethioate
• CAS: 1261294-43-2
• 化学式: C₃₀H₃₄O₆S
• 分子量: 522.662
• InChiKey: IYJRXQRVVGWICH-XZTOTZIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  37
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  88.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  methyl 6-S-acetyl-2,3,4-tri-O-benzyl-6-deoxy-β-D-allopyranoside 、 methyl 6-deoxy-6-iodo-2,3,4-tri-O-benzyl-α-D-glucopyranoside 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以86%的产率得到(methyl 2,3,4-tri-O-benzyl-6-deoxy-α-D-glucopyranosid-6-yl)-(methyl 2',3',4'-tri-O-benzyl-6'-deoxy-β-D-allopyranosid-6'-yl) sulfide
  参考文献：
  名称：

  Efficient synthesis of (6-deoxy-glycopyranosid-6-yl) sulfone derivatives and their effect on Ca2+-ATPase

  摘要：

  Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their biological potential against Ca2+-ATPase, an important enzyme involves in tranporting Ca2+ across the cell membranes. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.09.069
• 作为产物：
  描述：

  methyl 2,3,4-tri-O-benzyl-6-deoxy-6-iodo-β-D-allo-pyranoside 、 potassium thioacetate 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以85%的产率得到methyl 6-S-acetyl-2,3,4-tri-O-benzyl-6-deoxy-β-D-allopyranoside
  参考文献：
  名称：

  Efficient synthesis of (6-deoxy-glycopyranosid-6-yl) sulfone derivatives and their effect on Ca2+-ATPase

  摘要：

  Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their biological potential against Ca2+-ATPase, an important enzyme involves in tranporting Ca2+ across the cell membranes. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.09.069

文献信息

• Efficient synthesis of (6-deoxy-glycopyranosid-6-yl) sulfone derivatives and their effect on Ca2+-ATPase
  作者：Chinmoy Mukherjee、Swatilekha Ghosh、Pinki Nandi、Parimal C. Sen、Anup Kumar Misra

  DOI：10.1016/j.ejmech.2010.09.069

  日期：2010.12

  Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their biological potential against Ca2+-ATPase, an important enzyme involves in tranporting Ca2+ across the cell membranes. (C) 2010 Elsevier Masson SAS. All rights reserved.