2-(acetylamino)azulene | 50472-24-7

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 2-(acetylamino)azulene
• 英文别名: 2-acetylaminoazulene；N-azulen-2-yl-acetamide；N-Azulen-2-yl-acetamid；2-Acetamino-azulene；2-Acetamino-azulen；2-Acetaminoazulene；N-azulen-2-ylacetamide
• CAS: 50472-24-7
• 化学式: C₁₂H₁₁NO
• 分子量: 185.225
• InChiKey: MDSSFBYPYSVTIN-UHFFFAOYSA-N

物化性质

• 熔点：
  168 °C
• 沸点：
  412.9±14.0 °C(Predicted)
• 密度：
  1.182±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(acetylamino)azulene 在 sodium hydroxide 、 三氯氧磷 作用下， 生成 2-Amino-1-formyl-azulen
  参考文献：
  名称：

  The Synthesis of Azuleno[2,1-b]pyridine Derivatives

  摘要：

  DOI：

  10.1246/bcsj.36.633

文献信息

• Tropylation of Azulene, 1-Oxaazulan-2-one, and Their Derivatives, and Electrophilic Reactions of the Tropylazulene Derivatives
  作者：Tetsuo Nozoe、Takashi Toda、Toyonobu Asao、Akira Yamanouchi

  DOI：10.1246/bcsj.41.2935

  日期：1968.12

  The tropylation of azulene, oxaazulan-2-one, and their derivatives was investigated, and various 1 and/or 3-tropylazulenes and 3-tropyloxaazulan-2-ones were obtained. The NMR, UV, and visible spectra of these tropylazulenes were then discussed. Some electrophilic reactions, such as azo-coupling and the acid treatment of four kinds of tropylazulenes, were studied, and it was found that exchanges of

  研究了 azulene、oxaazulan-2-one 及其衍生物的 tropylation，并获得了各种 1 和/或 3-tropylazulenes 和 3-tropyloxaazulan-2-ones。然后讨论了这些原花青素的 NMR、UV 和可见光谱。对偶氮偶联和4种原基天青烯的酸处理等亲电反应进行了研究，发现发生了托酰基交换和攻击亲电反应。
• A New Convenient Synthesis of 1,2′-Biazulenes by Photolysis of 2-Diazo-1,3-dicyanoazulen-6(2<i>H</i>)-one with Azulene Derivatives
  作者：Shih-Jue Lin、Shuan-Ya Jiang、Tian-Chyuan Huang、Cheng-Shyan Dai、Pai-Feng Tsai、Hitoshi Takeshita、Yun-Sha -Lin、(the late) Tetsuo Nozoe

  DOI：10.1246/bcsj.70.3071

  日期：1997.12

  A photolysis of 2-diazo-1,3-dicyanoazulen-6(2H)-one in the presence of azulene derivatives in anhydrous ethyl acetate solution afforded 1,2′-biazulene derivatives, which are otherwise difficult to obtain, in good yields, nearly 90% or more. Accompanying by-products, 1,3-dicyanoazulen-6-ol and 2,5′-biazulene derivatives, were also characterized.

  2-diazo-1,3-dicyanoazulen-6(2H)-one 在 azulene 衍生物存在下在无水乙酸乙酯溶液中的光解得到 1,2'-biazulene 衍生物，否则很难以良好的产率获得，近 90% 或更多。还表征了伴随的副产物 1,3-dicyanoazulen-6-ol 和 2,5'-biazulene 衍生物。