2-(2,3-dichlorophenyl)-4,5-diphenyl-1H-imidazole | 111010-89-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2,3-dichlorophenyl)-4,5-diphenyl-1H-imidazole
• CAS: 111010-89-0
• 化学式: C₂₁H₁₄Cl₂N₂
• 分子量: 365.262
• InChiKey: HPJLATUXJWJVIX-UHFFFAOYSA-N

物化性质

• 沸点：
  564.3±50.0 °C(Predicted)
• 密度：
  1.301±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,3-二氯苯甲醛 、 联苯甲酰 在 ammonium acetate 作用下， 以 neat (no solvent) 为溶剂， 反应 0.12h， 以89%的产率得到2-(2,3-dichlorophenyl)-4,5-diphenyl-1H-imidazole
  参考文献：
  名称：

  Fe 3 O 4 @SiO 2 ·HM·SO 3 H作为可回收的多相纳米催化剂，在无溶剂条件下微波促进合成2,4,5-三取代的咪唑

  摘要：

  通过苯甲腈，苯甲醛和NH 4 OAc的三组分一锅反应，可以简单，高度通用和高效地合成2,4,5-三取代的咪唑。Fe 3 O 4 @SiO 2 ·HM·SO 3 H是一种非常有效的新型可循环多相催化剂，在微波辐射和无溶剂条件下催化了该反应。可以将催化剂回收用于随后的反应，并重复使用至少五轮，而不会明显降低其效率。

  DOI：

  10.1039/c5nj01273b

文献信息

• Fe₃O₄/SO₃H@zeolite-Y as a novel multi-functional and magnetic nanocatalyst for clean and soft synthesis of imidazole and perimidine derivatives
  作者：Mehdi Kalhor、Zohre Zarnegar

  DOI：10.1039/c9ra02910a

  日期：——

  chlorosulfonic acid with zeolite-NaY under solvent-free conditions, which was then supported by Fe3O4 nanoparticles to give SO3H@zeolite-Y (Fe3O4/SO3H@zeolite-Y) magnetic nanoparticles. Several techniques were used to evaluate the physical and chemical characterizations of the zeolitic nanostructures. Fe3O4-loaded sulfonated zeolite was applied as a novel multi-functional zeolite catalyst for the synthesis of

  本研究采用氯磺酸与沸石-NaY在无溶剂条件下反应合成SO 3 H@zeolite-Y，然后负载Fe 3 O 4纳米颗粒得到SO 3 H@zeolite-Y（Fe 3 O 4 /SO 3 H@zeolite-Y) 磁性纳米粒子。几种技术用于评估沸石纳米结构的物理和化学特性。铁3 O 4负载磺化沸石作为一种新型多功能沸石催化剂用于合成咪唑和哌啶衍生物。从绿色化学的角度来看，这种高效的方法具有收率好、产品纯度高、纳米催化剂可重复使用、反应条件简单、环境友好和化学过程经济等优点。
• Fe₃O₄@SiO₂·HM·SO₃H as a recyclable heterogeneous nanocatalyst for the microwave-promoted synthesis of 2,4,5-trisubstituted imidazoles under solvent free conditions
  作者：Hossein Naeimi、Dorsa Aghaseyedkarimi

  DOI：10.1039/c5nj01273b

  日期：——

  synthesis of 2,4,5-trisubstituted imidazoles is achieved through a three component one pot reaction of benzil, benzaldehyde and NH4OAc. This reaction has been catalyzed by Fe3O4@SiO2·HM·SO3H, a very efficient, novel recyclable heterogeneous catalyst, under microwave irradiation and solvent free conditions. The catalyst can be recovered for the subsequent reactions and reused for at least five rounds

  通过苯甲腈，苯甲醛和NH 4 OAc的三组分一锅反应，可以简单，高度通用和高效地合成2,4,5-三取代的咪唑。Fe 3 O 4 @SiO 2 ·HM·SO 3 H是一种非常有效的新型可循环多相催化剂，在微波辐射和无溶剂条件下催化了该反应。可以将催化剂回收用于随后的反应，并重复使用至少五轮，而不会明显降低其效率。
• Ionophore silica-coated magnetite nanoparticles as a recyclable heterogeneous catalyst for one-pot green synthesis of 2,4,5-trisubstituted imidazoles
  作者：Hossein Naeimi、Dorsa Aghaseyedkarimi

  DOI：10.1039/c5dt03488d

  日期：——

  Novel multi-SO3H functionalized strong Brønsted acidic ionic liquid coated magnetite nanoparticles have been prepared and applied as catalyst for the synthesis of 2,4,5-trisubstituted imidazoles. The results showed that a novel catalyst was very efficient for the reaction and could be magnetically separated and reused at least 6 times with less reduction in its catalytic activity. Operational simplicity

  新型multi-SO 3已经制备了H官能化的强布朗斯台德酸性离子液体涂覆的磁铁矿纳米颗粒，并将其用作合成2,4,5-三取代的咪唑的催化剂。结果表明，新型催化剂对反应非常有效，并且可以磁分离并重复使用至少6次，而催化活性降低得更少。该方法的最重要特征是操作简便，所用催化剂的成本低，产率高，环境友好，适用性广，可重复使用性好以及使用外磁体容易回收催化剂。通过傅里叶变换红外光谱（FT-IR），X射线衍射分析（XRD），场发射扫描电子显微镜（FE-SEM），能量色散X射线分析（EDX）对催化剂进行了表征
• JPS62145066A
  申请人：——

  公开号：JPS62145066A

  公开（公告）日：1987-06-29
• Preparation and Characterization of NiCoFe2O4 Nanoparticles as an Effective Catalyst for the Synthesis of Trisubstituted Imidazole Derivatives Under Solvent-free Conditions
  作者：Leila Hemmesi

  DOI：10.17344/acsi.2022.7633

  日期：——

  In this study, NiCoFe2O4 nanoparticles were prepared and used as a reactive catalyst for the synthesis of trisubstituted imidazoles. The multicomponent reactions of aromatic aldehydes, benzil and ammonium acetate were carried out under solvent-free and conventional heating conditions. In this reaction, some imidazole derivatives with high purity, short reaction times and high yields were obtained.

  在这项研究中，制备了NiCoFe2O4纳米颗粒并将其用作合成三取代咪唑的反应催化剂。芳香醛、苯偶酰和乙酸铵的多组分反应在无溶剂和常规加热条件下进行。该反应得到了一些纯度高、反应时间短、收率高的咪唑衍生物。通过FT-IR、XRD、EDX、VSM和SEM技术对制备的纳米催化剂进行了表征。此外，通过熔点、FT-IR和1H NMR分析鉴定了有机产物。