3-(2,3-dichlorophenyl)-1-(naphthalen-2-yl)prop-2-en-1-one | 797018-90-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(2,3-dichlorophenyl)-1-(naphthalen-2-yl)prop-2-en-1-one
• 英文别名: 3-(2,3-Dichlorophenyl)-1-naphthalen-2-ylprop-2-en-1-one
• CAS: 797018-90-7
• 化学式: C₁₉H₁₂Cl₂O
• 分子量: 327.21
• InChiKey: MVGRGZOEEPMMEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(2,3-dichlorophenyl)-1-(naphthalen-2-yl)prop-2-en-1-one 、 溶剂黄146 在 一水合肼 作用下， 反应 3.0h， 生成 1-[4,5-dihydro-3-(naphth-2-yl)-5-(2,3-dichlorophenyl)-1H-pyrazol-1-yl]ethanone
  参考文献：
  名称：

  Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones

  摘要：

  Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. The cytotoxic potential of chalcones which consists of C-6-C-3-C-6 units gets enhanced by the incorporation of pyrazole ring as proved by our earlier studies. Thus in the present work, pyrazoles of chalcones with ring A substituted by furan, naphthalene and variety of substituted phenyl rings has been prepared and evaluated for in vitro cytotoxic activity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines.All the synthesized compounds were evaluated for in vitro cytotoxicity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines. Compound 68 was found to be the most potent showing broad spectrum of cytotoxicity against all the cell lines .

  DOI：

  10.1007/s00044-011-9824-9
• 作为产物：
  描述：

  2,3-二氯苯甲醛 、 2-萘乙酮 在 pyrrolidine anchored in non-ordered mesoporous silica hybrid materials 作用下， 以 甲苯 为溶剂， 反应 8.0h， 以93%的产率得到3-(2,3-dichlorophenyl)-1-(naphthalen-2-yl)prop-2-en-1-one
  参考文献：
  名称：

  用于精细化学品生产的基于吡咯烷生成单元的活性基杂化有机硅材料

  摘要：

  混合催化剂：介孔二氧化硅中包含的“吡咯烷型”片段的高催化活性、稳定性和可回收性，用于在微波辐射下通过碱催化反应（如 Knoevenagel、Claisen-Schmidt 和 Henry 反应）制备 α,β-不饱和化合物，有助于可持续过程的发展，被报道。

  DOI：

  10.1002/cctc.202101031

文献信息

• Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones
  作者：Kunal Nepali、Kanika Kadian、Ritu Ojha、Rajni Dhiman、Atul Garg、Gagandip Singh、Abhishek Buddhiraja、Preet Mohinder Singh Bedi、Kanaya Lal Dhar

  DOI：10.1007/s00044-011-9824-9

  日期：2012.10

  Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. The cytotoxic potential of chalcones which consists of C-6-C-3-C-6 units gets enhanced by the incorporation of pyrazole ring as proved by our earlier studies. Thus in the present work, pyrazoles of chalcones with ring A substituted by furan, naphthalene and variety of substituted phenyl rings has been prepared and evaluated for in vitro cytotoxic activity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines.All the synthesized compounds were evaluated for in vitro cytotoxicity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines. Compound 68 was found to be the most potent showing broad spectrum of cytotoxicity against all the cell lines .
• Active Base Hybrid Organosilica Materials based on Pyrrolidine Builder Units for Fine Chemicals Production
  作者：Sebastián Llopis、Alexandra Velty、Urbano Díaz

  DOI：10.1002/cctc.202101031

  日期：2021.12.7

  high catalytic activity performance, stability and recyclability of “pyrrolidine type” fragments included in mesoporous silica for the preparation of α,β-unsaturated compounds through base-catalyzed reactions such as Knoevenagel, Claisen-Schmidt and Henry reactions under microwave irradiation, contributing to the development of sustainable process, was reported.

  混合催化剂：介孔二氧化硅中包含的“吡咯烷型”片段的高催化活性、稳定性和可回收性，用于在微波辐射下通过碱催化反应（如 Knoevenagel、Claisen-Schmidt 和 Henry 反应）制备 α,β-不饱和化合物，有助于可持续过程的发展，被报道。