3-Ethyl-1-cyclooctanon | 41416-34-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Ethyl-1-cyclooctanon
• 英文别名: 3-Aethylcyclooctanon；3-Ethylcyclooctan-1-one
• CAS: 41416-34-6
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: DAHXJQBIVWXDAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (Z)-cyclooct-2-enone 、 diethylzinc 在 tetrakis(acetonitrile)copper(I)tetrafluoroborate (+)-N-Boc-D-Phe-D-Val-(S)-2-(Ph₂P-methyl)pyrrolidine 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 36.0h， 生成 3-Ethyl-1-cyclooctanon 、 3-Ethyl-1-cyclooctanon
  参考文献：
  名称：

  肽酰胺基单膦配体用于铜催化不对称共轭二有机锌与环烯酮的加成反应

  摘要：

  （S）-2-[（（二苯基膦基）甲基]吡咯烷的肽基修饰为有机锌试剂与环烯酮的高效铜催化不对称共轭加成反应提供了一个二肽连接的酰胺基单膦配体，从而在高对映体选择性下得到了3-烷基化的环烷酮ee高达98％。讨论了预测反应立体化学的模型。

  DOI：

  10.1002/adsc.200600562

文献信息

• Peptidic Amidomonophosphane Ligand for Copper-Catalyzed Asymmetric Conjugate Addition of Diorganozincs to Cycloalkenones
  作者：Takahiro Soeta、Khalid Selim、Masami Kuriyama、Kiyoshi Tomioka

  DOI：10.1002/adsc.200600562

  日期：2007.3.5

  pyrrolidine gave a dipeptide-connected amidomonophosphane ligand for the highly efficient, copper-catalyzed asymmetric conjugate addition reaction of organozinc reagents with cycloalkenones, giving 3-alkylated cycloalkanones in high enantioselectivity of up to 98 % ee. A model that predicts the stereochemistry of the reaction is discussed.

  （S）-2-[（（二苯基膦基）甲基]吡咯烷的肽基修饰为有机锌试剂与环烯酮的高效铜催化不对称共轭加成反应提供了一个二肽连接的酰胺基单膦配体，从而在高对映体选择性下得到了3-烷基化的环烷酮ee高达98％。讨论了预测反应立体化学的模型。
• Process for producing alcohols and ketones
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0531715A1

  公开（公告）日：1993-03-17

  The present invention provides a process for the oxidation of straight-chain, branched-chain or cyclic alkanes of 1-20 carbon atoms and benzene derivatives represented by the following formulas (1) - (2). The alcohols and ketones obtained by the oxidation of the alkanes mentioned above and those by the oxidation of the benzene derivatives mentioned above represented by the following formulas (3) - (6) are important as basic starting materials in producing various chemical products including resins, such as nylon and polyester, pharmaceuticals, agricultural chemicals, perfumes, dyes, etc.

  本发明提供了一种氧化 1-20 个碳原子的直链、支链或环状烷烃以及由下列式子 (1) - (2) 表示的苯衍生物的工艺。由上述烷烃氧化得到的醇和酮以及由下列式子（3）-（6）表示的上述苯衍生物氧化得到的醇和酮是生产各种化学产品的重要基本起始原料，包括树脂（如尼龙和聚酯）、药品、农药、香水、染料等。
• AZOLECARBOXAMIDE DERIVATIVE
  申请人：Astellas Pharma Inc.

  公开号：EP2009005A1

  公开（公告）日：2008-12-31

  Provided is an agent for treating or preventing urinary frequency, urinary urgency and urinary, incontinence which are associated with overactive bladder, a lower urinary tract disease such as interstitial cystitis and chronic prostatitis accompanied by lower urinary tract pain, and various diseases accompanied by pain. A novel azolecarboxamide derivative in which an azole ring such as thioazole or oxazole is bonded to a benzene ring, pyridine ring or pyrimidine ring through carboxamide was confirmed to have a potent trkA receptor-inhibitory activity and found to be an agent for treating or preventing lower urinary tract disease and various diseases accompanied by pain, which is excellent in efficacy and safety, and thus the present invention was accomplished.

  本发明提供了一种用于治疗或预防尿频、尿急和尿失禁的药物，这些症状与膀胱过度活动症、伴有下尿路疼痛的下尿路疾病（如间质性膀胱炎和慢性前列腺炎）以及伴有疼痛的各种疾病有关。一种新型唑甲酰胺衍生物，其中硫氮唑或噁唑等唑环通过羧酰胺键合到苯环、吡啶环或嘧啶环上，被证实具有强效的 trkA 受体抑制活性，并被发现是一种治疗或预防下尿路疾病和伴有疼痛的各种疾病的药物，其疗效和安全性都很好，从而完成了本发明。
• FLUORINE-CONTAINING COPOLYMER COMPOSITION AND METHOD FOR PRODUCING SAME
  申请人：Asahi Glass Company, Limited

  公开号：EP2450406B1

  公开（公告）日：2015-10-14
• FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS
  申请人：NAKANO Takashi

  公开号：US20120108723A1

  公开（公告）日：2012-05-03

  To provide a composition comprising a fluorocopolymer such as an ETFE which can be produced at a relatively low temperature, and its production process. A fluorocopolymer composition which comprises a fluorocopolymer such as an ETFE and a C 6-10 aliphatic compound having one carbonyl group, and which is in a solution state being at a temperature of at most the melting point of the fluorocopolymer, and a process for producing the fluorocopolymer composition, which comprises a step of dissolving the fluorocopolymer in the aliphatic compound having one carbonyl group at a temperature of at most the melting point of the fluorocopolymer.