1-Ethoxy-(Z)-2-ethylidenebicyclo<2.2.2>octane | 137495-17-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Ethoxy-(Z)-2-ethylidenebicyclo<2.2.2>octane
• 英文别名: (2Z)-1-ethoxy-2-ethylidenebicyclo[2.2.2]octane
• CAS: 137495-17-1
• 化学式: C₁₂H₂₀O
• 分子量: 180.29
• InChiKey: UYFJNHDBRUGUNT-JYOAFUTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-hydroxybicyclo<2.2.2>octan-2-one tert-butyldimethylsilyl ether 在 2,6-二甲基吡啶 作用下， 生成 1-Ethoxy-(Z)-2-ethylidenebicyclo<2.2.2>octane
  参考文献：
  名称：

  Takeuchi, K.; Ohga, Y.; Kitagawa, T., Journal de Chimie Physique et de Physico-Chimie Biologique, 1992, vol. 89, # 7, p. 1631 - 1638

  摘要：

  DOI：

文献信息

• Solvolyses of Bicyclo[2.2.2]oct-1-yl and 1-Adamantyl Systems Containing an Ethylidene Substituent on the 2-Position: Typical Examples of Rate Enhancements Ascribed to Relief of F-Strain
  作者：Yasushi Ohga、Motohiro Munakata、Toshikazu Kitagawa、Tomomi Kinoshita、Ken'ichi Takeuchi、Yasuo Oishi、Hiroshi Fujimoto

  DOI：10.1021/jo00094a012

  日期：1994.7

  The first typical examples are described on the solvolysis rate enhancements ascribed to the relief of F-strain between an alkyl group and the leaving group atom directly attached to the reaction center. The rates and products of solvolyses in ethanol were studied for 2-methylene- and (Z)- and (E)-2-ethylidenebicyclo[2.2.2]oct-1-yl triflates. Solvolyses were also conducted in ethanol and 2,2,2-trifluoroethanol (TFE) on 2-methylene- and (Z)- and (E)-2-ethylidene-1-adamantyl compounds having OMs, F, Cl, Br, or I asa leaving group. Ah the substrates gave the corresponding bridgehead substitution products as kinetic control products. The Z:E rate ratios at 25 degrees C were 217 +/- 6 for 2-ethylidenebicyclo[2.2.2]oct-1-yl triflates (ethanol) and 109 +/- Il(ethanol) and 117 fl(TFE)for 2-ethylidene-1-adamantyl mesylates. O-18 scrambling studies on the ethanolyses of(Z)- and (E)2-ethylidene-1-adamantyl mesylates showed that the titrimetrically determined Z:E rate ratios can be used as a measure of the rate ratios for the ionization step. The Z:E rate ratio in TFE at 25 degrees C for 2-ethylidene-1-adamantyl halides varied in the sequence F (ca. 70), Cl(1020 +/- 160), Br (2230 +/- 90), and I (9500 +/- 280). The significant increases in the rate ratio with the increase in the atomic size of halogen were explained in terms of the presence of F-strain in the Z substrates and its essential absence in the E substrates. Linear correlations were found in a plot of 1.36 x log[k(Z)/k(E)] against the MM2 steric energy difference between the Z and E isomers (slope 1.0) and against Hansch's Es, demonstrating the significance of F-strain effect in the enhanced rates of the (Z)-2-ethylidene-1-adamantyl system. These correlations showed an intercept of 0.8 kcal mol(-1), which suggested the greater stability of the (Z)-2-ethylidene-1-adamantyl cation than the corresponding E cation by this amount. Ab initio calculations (RHF/G-31G**) showed that the Z cation is more stable than the E cation by 1.0 kcal mol(-1), and that the large Z:E rate ratios are in part ascribed to the difference in the cation stability.
• Marked leaving group strain in (Z)-2-ethylidenebicyclo[2.2.2]oct-1-yl triflate and its significant relief in (Z)-2-ethylidenebicyclo[3.2.2]non-1-yl mesylate
  作者：Kenichi Takeuchi、Yasushi Ohga、Toshikazu Kitagawa

  DOI：10.1021/jo00017a003

  日期：1991.8

  The rate of ethanolysis at 25-degrees-C of (Z)-2-ethylidenebicyclo[2.2.2]oct-1-yl triflate [(Z)-3] is 217 times faster than that of its E isomer, whereas more flexible (Z)-2-ethylidenebicyclo[3.2.2]non-1-yl mesylate solvolyzes 3.4 times slower than its E isomer, indicating marked leaving-group strain in the ground state of (Z)-3, which is supported by MM2 calculations.
• Takeuchi, K.; Ohga, Y.; Kitagawa, T., Journal de Chimie Physique et de Physico-Chimie Biologique, 1992, vol. 89, # 7, p. 1631 - 1638
  作者：Takeuchi, K.、Ohga, Y.、Kitagawa, T.

  DOI：——

  日期：——