7-(2-Methylphenyl)quinoline | 1182846-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-(2-Methylphenyl)quinoline
• CAS: 1182846-73-6
• 化学式: C₁₆H₁₃N
• 分子量: 219.286
• InChiKey: ZHGATIUOCWTOMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  7-氯喹啉 、 2-甲基苯硼酸 在 potassium phosphate 、 dicyclohexyl (2’,4’,6-triisopropyl-[1,1’-biphenyl]-2-yl)phosphine 、 palladium diacetate 作用下， 以 水 、 甲苯 为溶剂， 以77%的产率得到7-(2-Methylphenyl)quinoline
  参考文献：
  名称：

  7-Chloroquinoline: a versatile intermediate for the synthesis of 7-substituted quinolines

  摘要：

  A practical synthesis of 7-mono-substituted quinolines has been achieved. Selective reduction of the inexpensive commercial reagent 4,7-dichloroquinoline affords 7-chloroquinoline, which has been converted into more complex 7-mono-substituted quinolines through a series of Pd-catalyzed cross coupling reactions. These studies include the first examples of Suzuki reactions for the preparation of 7-mono-substituted quinolines as well as the first application of the Sonagashira reaction for the synthesis of 7-substituted quinolines. This strategy has been extended to the preparation of 2,7-di-substituted quinolines. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.077

文献信息

• 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
  申请人：OSI Pharmaceuticals, Inc.

  公开号：EP2305682A1

  公开（公告）日：2011-04-06

  The invention provides a compound comprising cis-3-[8-amino-1-(2-phenylquinolin-7-yl)-imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种包含顺式-3-[8-氨基-1-(2-苯基喹啉-7-基)-咪唑并[1,5-a]吡嗪-3-基]-1-甲基环丁醇或其药学上可接受的盐的化合物。