4-Ethyl-3-methyloxetan-2-one | 115367-79-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 4-Ethyl-3-methyloxetan-2-one
• CAS: 115367-79-8；138622-96-5；138622-97-6
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: VGKQULDZBZYNPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Ethyl-3-methyloxetan-2-one 在 magnesium bromide ethyl etherate 作用下， 以 乙醚 为溶剂， 反应 10.0h， 以62.5%的产率得到3,5-二甲基四氢呋喃-2-酮
  参考文献：
  名称：

  Black, T. Howard; Fields, John D., Synthetic Communications, 1988, vol. 18, # 2, p. 125 - 130

  摘要：

  DOI：
• 作为产物：
  描述：

  3-羟基-2-甲基戊酸 在 吡啶 、 苯磺酰氯 作用下， 以69.7%的产率得到4-Ethyl-3-methyloxetan-2-one
  参考文献：
  名称：

  Black, T. Howard; Fields, John D., Synthetic Communications, 1988, vol. 18, # 2, p. 125 - 130

  摘要：

  DOI：

文献信息

• [EN] SYNTHESIS OF HIGH CALORIC FUELS AND CHEMICALS<br/>[FR] SYNTHÈSE DE COMBUSTIBLES ET DE PRODUITS CHIMIQUES À FORT POUVOIR CALORIFIQUE
  申请人：PIONEER ENERGY

  公开号：WO2013070966A1

  公开（公告）日：2013-05-16

  In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.

  在一种实施例中，本申请公开了一种从合成气和生物质中选择性合成高级醇类和烃类的方法，这些物质可用作燃料和工业化学品。酮烯和酮化学以及加氢反应被用来合成燃料和化学品。在另一种实施例中，用于形成燃料和化学品的酮烯可以从乙酸制造，而乙酸可以从煤、生物质、天然气等生产的合成气中合成。
• Synthesis of High Caloric Fuels and Chemicals
  申请人：Henri John

  公开号：US20130118063A1

  公开（公告）日：2013-05-16

  In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.

  在一种实施方式中，本申请公开了从合成气和生物质中选择性合成高级醇和烃类的方法，这些高级醇和烃类可用作燃料和工业化学品。使用酮和酮化学以及氢化反应来合成燃料和化学品。在另一种实施方式中，用于形成燃料和化学品的酮可以从乙酸中制造，而乙酸又可以从煤、生物质、天然气等合成气中合成。
• NOVEL METHOD FOR THE ASYMMETRIC SYNTHESIS OF BETA-LACTONE COMPOUNDS
  申请人：Smith Jeffrey W.

  公开号：US20100173982A1

  公开（公告）日：2010-07-08

  The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

  本发明涉及通过向受试者施用有效量的β-内酰胺来治疗癌症的方法。本发明还涉及通过向受试者施用脂肪酸合成酶抑制剂的有效量来抑制血管生成的方法。这些方法可用于治疗各种癌症和其他疾病和病况。本发明还涉及识别β-内酰胺和其他化合物的方法，这些化合物可用于本发明的治疗肿瘤、抑制血管生成以及涉及病理性血管生成的疾病和病况的方法。本发明还涉及β-内酰胺的合成方法和新型β-内酰胺化合物。
• SYNTHESIS OF C3-C7 ALCOHOL FUEL COMPOSITIONS
  申请人：Pioneer Energy, Inc.

  公开号：US20150267135A1

  公开（公告）日：2015-09-24

  In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.

  在一种实施例中，本申请公开了从合成气和生物质中选择性合成高级醇和烃的方法，这些高级醇和烃可用作燃料和工业化学品。使用酮和酮化学以及氢化反应来合成燃料和化学品。在另一种实施例中，用于形成燃料和化学品的酮可以从乙酸中制造，而乙酸则可以从煤、生物质、天然气等产生的合成气合成。
• BLACK, T. HOWARD;FIELDS, JOHN D., SYNTH. COMMUN., 18,(1988) N 2, 125-130
  作者：BLACK, T. HOWARD、FIELDS, JOHN D.

  DOI：——

  日期：——