N-hydroxy-4-(1-methyl-1H-benzo[d]imidazole-2-yl)benzamide | 579510-98-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-hydroxy-4-(1-methyl-1H-benzo[d]imidazole-2-yl)benzamide
• 英文别名: N-hydroxy-4-(1-methylbenzimidazol-2-yl)benzamide
• CAS: 579510-98-8
• 化学式: C₁₅H₁₃N₃O₂
• 分子量: 267.287
• InChiKey: UKMGHYLOCPNCCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  67.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(1-甲基-1H-苯并咪唑-2-基)-苯甲酸甲酯 在 羟胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以36%的产率得到N-hydroxy-4-(1-methyl-1H-benzo[d]imidazole-2-yl)benzamide
  参考文献：
  名称：

  BENZO-HETEROCYCLIC COMPOUND AND COMPOSITION FOR PREVENTING OR TREATING CANCER DISEASE, CONTAINING SAME AS ACTIVE INGREDIENT

  摘要：

  一种新的苯杂环化合物或其药用盐在癌细胞系中显示出很高的抗增殖效果。利用这一点，用于预防或治疗癌症的药物组合物可以包括该化合物或其药用盐作为活性成分。此外，用于预防或改善癌症的保健功能食品组合物可以包括该化合物或其药用盐作为活性成分。这种药物组合物或保健功能食品组合物可以有效地预防或治疗各种癌症疾病。

  公开号：

  US20210387951A1

文献信息

• Novel bicyclic hydroxamates as inhibitors of histone deacetylase
  申请人：Leahy M Ellen

  公开号：US20060058553A1

  公开（公告）日：2006-03-16

  The present invention is directed to certain bicyclic hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed

  本发明涉及某些双环羟肟衍生物，它们是组蛋白去乙酰化酶的抑制剂，因此可以用于治疗与组蛋白去乙酰化酶活性相关的疾病。本发明还公开了制备这些化合物的制药组合物和过程。
• NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE
  申请人：Axys Pharmaceuticals

  公开号：EP1472216A2

  公开（公告）日：2004-11-03
• [EN] NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE<br/>[FR] NOUVEAUX HYDROXAMATES BICYCLIQUES SERVANT D'INHIBITEURS DE HISTONE DESACETYLASE
  申请人：AXYS PHARMACEUTICALS

  公开号：WO2003066579A2

  公开（公告）日：2003-08-14

  The present invention is directed to certain bicyclic hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed
• BENZO-HETEROCYCLIC COMPOUND AND COMPOSITION FOR PREVENTING OR TREATING CANCER DISEASE, CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：INDUSTRY ACADEMIC COOPERATION FOUNDATION KEIMYUNG UNIVERSITY

  公开号：US20210387951A1

  公开（公告）日：2021-12-16

  A novel benzoheterocycle compound or a pharmaceutically acceptable salt thereof showed a high anti-proliferative effect against cancer cell lines. Using this, a pharmaceutical composition for preventing or treating cancer disease can comprise the compound or a pharmaceutically acceptable salt thereof as an active ingredient. In addition, a health functional food composition for preventing or improving cancer disease can include the compound or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition or health functional food composition can effectively prevent or treat various cancer diseases.

  一种新的苯杂环化合物或其药用盐在癌细胞系中显示出很高的抗增殖效果。利用这一点，用于预防或治疗癌症的药物组合物可以包括该化合物或其药用盐作为活性成分。此外，用于预防或改善癌症的保健功能食品组合物可以包括该化合物或其药用盐作为活性成分。这种药物组合物或保健功能食品组合物可以有效地预防或治疗各种癌症疾病。