1-cyclopropyl-6-fluoro-8-methoxy-7-(4-cyclopropylamino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | 473839-27-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-cyclopropylamino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
• 英文别名: WCK 915；1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(4-cyclopropylamino-3,3-dimethyl-1-piperidinyl)-4-oxo-quinoline-3-carboxylic acid；1-Cyclopropyl-7-[4-(cyclopropylamino)-3,3-dimethylpiperidin-1-yl]-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid
• CAS: 473839-27-9
• 化学式: C₂₄H₃₀FN₃O₄
• 分子量: 443.518
• InChiKey: NSXQTKCKRAQXJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  82.1
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  (1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinoline-carboxylato-κO3)difluoro-Boron 、 4-cyclopropylamino-3,3-dimethylpiperidine 在 三乙胺 作用下， 以 乙腈 、 乙醇 为溶剂， 反应 22.0h， 以31%的产率得到1-cyclopropyl-6-fluoro-8-methoxy-7-(4-cyclopropylamino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  WCK 1152, WCK 1153: Discovery and structure activity relationship for the treatment of resistant pneumococcal and staphylococcal respiratory infections

  摘要：

  DOI：

  10.1016/j.bmcl.2022.128665

文献信息

• Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation,compositions and use as medicaments
  申请人：WOCKHARDT LIMITED

  公开号：US20030216568A1

  公开（公告）日：2003-11-20

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗菌7-取代哌啶酮羧酸衍生物，以及它们的光学异构体、对映异构体或对映体，以及其药学上可接受的盐、水合物、前药、多晶形和假多晶形，以及它们的制备、组成和用途。
• Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-Quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
  申请人：WOCKHARDT LIMITED

  公开号：US20030096812A1

  公开（公告）日：2003-05-22

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗微生物7-取代哌啶酮羧酸衍生物，其光学异构体，对映异构体或对映体，以及其药学上可接受的盐，水合物，前药，多晶形和假多晶形，以及其制备，组成和使用。
• Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
  申请人：De Souza John Noel

  公开号：US20050065164A1

  公开（公告）日：2005-03-24

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向、手性、广谱抗微生物的7-取代哌啶酮羧酸衍生物，以及它们的光学异构体、对映异构体或对映体、药学上可接受的盐、水合物、前药、多晶型和假多晶型，以及它们的制备、组合物和用途。
• New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
  申请人：De Souza Noel John

  公开号：US20080214608A1

  公开（公告）日：2008-09-04

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗微生物7-取代哌啶酮羧酸衍生物，以及它们的光学异构体、对映异构体或对映体，以及药学上可接受的盐、水合物、前药、多晶形和伪多晶形，以及它们的制备、组成和使用。
• CHIRAL BROAD-SPECTRUM ANTIBACTERIAL 7-SUBSTITUTED PIPERIDINO-QUINOLONE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS
  申请人：Wockhardt Limited

  公开号：EP1392677A2

  公开（公告）日：2004-03-03