2-羟基-N,N-二甲基丙酰胺 | 35123-06-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-羟基-N,N-二甲基丙酰胺
• 中文别名: L-硫代脯氨酸；N,N-二甲基-2-羟基丙酰胺
• 英文名称: 2-hydroxy-N,N-dimethyl-propanamide
• 英文别名: N,N-dimethyl lactamide；2-Hydroxy-N,N-dimethylpropanamide
• CAS: 35123-06-9
• 化学式: C₅H₁₁NO₂
• 分子量: 117.148
• InChiKey: YEBLAXBYYVCOLT-UHFFFAOYSA-N

物化性质

• 沸点：
  78.6-79.6 °C(Press: 4 Torr)
• 密度：
  1.033±0.06 g/cm3(Predicted)
• LogP：
  -0.94 at 23℃ and pH7.6
• 表面张力：
  70.2mN/m at 1g/L and 22℃
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924199090
• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  2-羟基-N,N-二甲基丙酰胺 在 tricalcium diphosphate 作用下， 生成 N,N-二甲基丙烯酰胺
  参考文献：
  名称：

  Preparation of acrylic acid derivatives from alpha-or beta-hydroxy carboxylic acids

  摘要：

  该发明涉及一种从α-或β-羟基羧酸或酯或前体高产率和高选择性制备α,β-不饱和酸、酯和酰胺的过程。α,β-不饱和酸或酯可以在特定的脱水和/或酯化催化剂存在下制备。α,β-不饱和酰胺或取代酰胺可以在脱水和/或酰胺化催化剂存在下选择性地制备。α-或β-羟基羧酸或前体的来源最好是可再生资源。前体在此处被定义。

  公开号：

  US20050222458A1
• 作为产物：
  描述：

  Brenztraubensaeuredimethylamid 在 乙醇 、 zinc(II) chloride 、 锌 作用下， 反应 1.0h， 以95%的产率得到2-羟基-N,N-二甲基丙酰胺
  参考文献：
  名称：

  Toda, Fumio; Tanaka, Koichi; Tange, Hiroshi, Journal of the Chemical Society. Perkin transactions I, 1989, p. 1555 - 1556

  摘要：

  DOI：
• 作为试剂：
  描述：

  D-GlcNAc 、 4-硝基苯基-D-吡喃葡糖苷 在 2-羟基-N,N-二甲基丙酰胺 、 Thermus thermophilus β-galactosidase 作用下， 以 aq. phosphate buffer 为溶剂， 反应 3.0h， 以7%的产率得到p-nitrophenyl 3-O-β-D-galactopyranosyl-β-D-galactopyranoside
  参考文献：
  名称：

  Optimised N-acetyl-d-lactosamine synthesis using Thermus thermophilus β-galactosidase in bio-solvents

  摘要：

  Synthesis of N-acetyl-D-lactosamine (Gal-beta[1 -> 4]GlcNAc, LacNAc) catalyzed by beta-galactosidase from Thermus thermophilus (TTP0042) is affected by side reactions that give as result very low yields (about 20%) of LAcNAc when the reaction is performed in buffer. The process is improved (up to 91% of disaccharide yield) when the reaction takes place in the presence of solvents from biomass (bio-solvents) at 2.0 M concentration. Most of the solvents tested increased the LacNAc synthesis and reduced the undesired side reactions. In order to understand the possible effects of these solvents over the enzyme regioselectivity, we developed a conformational study of the enzyme structure in the presence of a selected bio-solvent by circular dichroism and fluorescence. According to this study, we were able to conclude that the presence of bio-solvents in the reaction media modifies the enzyme secondary and tertiary structure and this may be the cause of the regioselectivity changes observed in the trans-glycosylation reaction. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.11.053

文献信息

• ETHER-AMIDE COMPOUNDS AND USES THEREOF
  申请人：Vidal Thierry

  公开号：US20120302791A1

  公开（公告）日：2012-11-29

  Novel ether-amide compounds are described. Uses of the compounds, in particular as solvents, for example in phytosanitary formulations are also described.

  描述了新型醚酰胺化合物。还描述了该化合物的用途，特别是作为溶剂，例如在植物保护制剂中的用途。
• Production methods of epoxytriazole derivative and intermediate therefor
  申请人：Sumika Fine Chemicals Co., Ltd.

  公开号：US20030236419A1

  公开（公告）日：2003-12-25

  An epoxytriazole derivative (V) useful as an intermediate for anti-fungal agents and an intermediate therefor having high quality can be produced economically and efficiently by the following industrial means. A compound of the following formula (I) is reacted with trimethyloxosulfonium salt and the like in the presence of a base to give compound (II), this compound is converted to compound (IV), and this compound is reacted with 1,2,4-triazole in the presence of a base. 1 wherein Ar is a phenyl group optionally substituted by 1 to 3 halogen atom(s) or trifluoromethyl group, R is a hydrogen atom or lower alkyl group, and X is a leaving group.

  一种环氧三唑衍生物（V），作为抗真菌剂的中间体以及具有高质量的中间体，可以通过以下工业手段经济高效地生产。在碱的存在下，将以下式（I）的化合物与三甲氧磺酸盐等反应，得到化合物（II），将此化合物转化为化合物（IV），然后在碱的存在下，将此化合物与1,2,4-三唑反应。其中Ar为苯基，可以选择性地被1至3个卤原子或三氟甲基基团取代，R为氢原子或较低的烷基基团，X为离去基团。
• Method For Producing Amides In The Presence Of Superheated Water
  申请人：Krull Matthias

  公开号：US20110089021A1

  公开（公告）日：2011-04-21

  The invention relates to a method for producing carboxylic acid amides, according to which at least one carboxylic acid of formula (I) R 3 —COON   (I) wherein R 3 is hydrogen or an optionally substituted hydrocarbon radical comprising between 1 and 50 carbon atoms, is reacted with at least one amine of formula (II) HNR 1 R 2 (II) wherein R 1 and R 2 are independently hydrogen or an optionally substituted hydrocarbon radical comprising between 1 and 100 C atoms, to form an ammonium salt, and said ammonium salt is reacted in the presence of superheated water, under microwave irradiation, to form a carboxylic acid amide.

  该发明涉及一种生产羧酸酰胺的方法，根据该方法，至少一种具有以下结构的羧酸（I）R3—COON（I）其中R3是氢或含有1至50个碳原子的可选择取代的烃基，与至少一种具有以下结构的胺（II）HNR1R2（II）其中R1和R2独立地是氢或含有1至100个碳原子的可选择取代的烃基，反应形成一种铵盐，然后在超热水存在下，在微波辐射下，将该铵盐反应形成一种羧酸酰胺。
• Kinetic Resolution of Racemic 2-Hydroxyamides Using a Diphenylacetyl Component as an Acyl Source and a Chiral Acyl-Transfer Catalyst
  作者：Takatsugu Murata、Tatsuya Kawanishi、Akihiro Sekiguchi、Ryo Ishikawa、Keisuke Ono、Kenya Nakata、Isamu Shiina

  DOI：10.3390/molecules23082003

  日期：——

  2-hydroxyamide derivatives are produced based on the kinetic resolution of racemic 2-hydroxyamides with a diphenylacetyl component and (R)-benzotetramisole ((R)-BTM), a chiral acyl-transfer catalyst, via asymmetric esterification and acylation. It was revealed that a tertiary amide can be used with this novel protocol to achieve high selectivity (22 examples; s-value reaching over 250). The resulting chiral

  基于具有二苯基乙酰基组分的外消旋2-羟基酰胺和手性酰基转移催化剂（R）-苯并四咪唑（（R）-BTM）的外消旋2-羟基酰胺的动力学拆分，通过不对称酯化和酰化反应，制备了各种旋光的2-羟基酰胺衍生物。揭示了叔酰胺可与该新颖方案一起使用以实现高选择性（22个实例； s值达到250以上）。所得到的手性化合物可以转化为其他有用的结构，同时保持它们的手性。
• METHOD FOR PREPARING ALKYL LACTATE AND A METHOD FOR PREPARING LACTAMIDE USING THE SAME
  申请人：Yoon Sung-Cheol

  公开号：US20130079547A1

  公开（公告）日：2013-03-28

  This disclosure relates to a method for preparing alkyl lactate with high yield and high selectivity, comprising the step of reacting glycerol with water or alcohol in the presence of a catalyst. In addition, the present invention provides a method for efficiently preparing lactamide using the alkyl lactate.

  本公开涉及一种制备高收率和高选择性的烷基乳酸的方法，包括在催化剂存在下将甘油与水或醇反应的步骤。此外，本发明还提供了一种利用烷基乳酸高效制备乳酰胺的方法。