3-(3,4-dichlorophenyl)-1,2-diphenyl-3-(naphthalen-2-ylamino)propan-1-one | 1221882-23-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(3,4-dichlorophenyl)-1,2-diphenyl-3-(naphthalen-2-ylamino)propan-1-one
• 英文别名: 3-(3,4-Dichlorophenyl)-3-(naphthalen-2-ylamino)-1,2-diphenylpropan-1-one
• CAS: 1221882-23-0
• 化学式: C₃₁H₂₃Cl₂NO
• 分子量: 496.436
• InChiKey: OOQKIQRKYHSRAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二苯基乙酮 、 2-萘胺 、 3,4-二氯苯甲醛 在 苄基三乙基氯化铵 作用下， 以 水 为溶剂， 反应 16.0h， 以78%的产率得到3-(3,4-dichlorophenyl)-1,2-diphenyl-3-(naphthalen-2-ylamino)propan-1-one
  参考文献：
  名称：

  Facile and Green Method for the Synthesis of β-Aminoketone Derivatives in Aqueous Media

  摘要：

  Three-component reaction of aromatic aldehyde, 2-naphthalenamine, and 1,2-diphenylethanone in aqueous media catalyzed by triethylbenzylammonium chloride (TEBAC) at 90 degrees C gave 3-aryl-3-(naphthalen-2-ylamino)-1,2-diphenylpropan-1-one derivatives. The enol form of 1,2-diphenylethanone was tentatively proposed to participate in the formation of the products. Compared with previous methods, this three-component reaction has the advantages of green solvent, good yields, and operational simplicity.

  DOI：

  10.1080/00397910903029859

文献信息

• Facile and Green Method for the Synthesis of <font>β</font>-Aminoketone Derivatives in Aqueous Media
  作者：Xiang-Shan Wang、Jie Zhou、Ke Yang、Qing Li

  DOI：10.1080/00397910903029859

  日期：2010.3.12

  Three-component reaction of aromatic aldehyde, 2-naphthalenamine, and 1,2-diphenylethanone in aqueous media catalyzed by triethylbenzylammonium chloride (TEBAC) at 90 degrees C gave 3-aryl-3-(naphthalen-2-ylamino)-1,2-diphenylpropan-1-one derivatives. The enol form of 1,2-diphenylethanone was tentatively proposed to participate in the formation of the products. Compared with previous methods, this three-component reaction has the advantages of green solvent, good yields, and operational simplicity.