N-(phenylacetyl)-L-prolyl-DL-α-methylphenylalanyl-L-arginine | 88084-32-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(phenylacetyl)-L-prolyl-DL-α-methylphenylalanyl-L-arginine
• 英文别名: benzylcarbonyl-Pro-DL-aMePhe-Arg-OH；(2S)-5-(diaminomethylideneamino)-2-[[2-methyl-3-phenyl-2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]propanoyl]amino]pentanoic acid
• CAS: 88084-32-6
• 化学式: C₂₉H₃₈N₆O₅
• 分子量: 550.658
• InChiKey: XPKCAZOOBIVFRL-AYVJMEFPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  40
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  180
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (S)-1-phenylacetyl-pyrrolidine-2-carboxylic acid benzyl ester 在 palladium on activated charcoal N-乙基马来酰亚胺 、 sodium hydroxide 、 氢气 、 1-羟基苯并三唑 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 为溶剂， 25.0 ℃ 、413.69 kPa 条件下， 反应 90.0h， 生成 N-(phenylacetyl)-L-prolyl-DL-α-methylphenylalanyl-L-arginine
  参考文献：
  名称：

  Tri- and tetrapeptide analogs of kinins as potential renal vasodilators

  摘要：

  Tri- and tetrapeptide analogues were synthesized and evaluated as renal vasodilators. These peptides were prepared by standard coupling reactions, which also provided good yields with hindered alpha-methyl amino acid derivatives. Preliminary evidence of renal vasodilator activity was determined in anesthetized dogs by measuring the effects on renal blood flow and calculating the accompanying changes in renal vascular resistance. The most potent compounds contained, in their basic structure, the L-prolyl-DL-alpha-methylphenylalanyl-L-arginine and L-prolyl-DL-alpha-methylphenylalanylglycyl-L-proline arrays. Substitution on the N-terminal proline with 4-phenylbutyryl and 4-(4-hydroxyphenyl)butyryl side chains produced enhanced renal vasodilator activity and, in certain cases, selectivity for the renal vasculature.

  DOI：

  10.1021/jm00369a017

文献信息

• Tri- and tetrapeptide analogs of kinins as potential renal vasodilators
  作者：Francis R. Pfeiffer、Pamela A. Chambers、Eileen E. Hilbert、Paul W. Woodward、Dennis M. Ackerman

  DOI：10.1021/jm00369a017

  日期：1984.3

  Tri- and tetrapeptide analogues were synthesized and evaluated as renal vasodilators. These peptides were prepared by standard coupling reactions, which also provided good yields with hindered alpha-methyl amino acid derivatives. Preliminary evidence of renal vasodilator activity was determined in anesthetized dogs by measuring the effects on renal blood flow and calculating the accompanying changes in renal vascular resistance. The most potent compounds contained, in their basic structure, the L-prolyl-DL-alpha-methylphenylalanyl-L-arginine and L-prolyl-DL-alpha-methylphenylalanylglycyl-L-proline arrays. Substitution on the N-terminal proline with 4-phenylbutyryl and 4-(4-hydroxyphenyl)butyryl side chains produced enhanced renal vasodilator activity and, in certain cases, selectivity for the renal vasculature.