1-butyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one | 689767-21-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-butyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one
• 英文别名: 1-butyl-3-hydroxy-3-[2-oxo-2-(pyridin-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one；1-butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one
• CAS: 689767-21-3
• 化学式: C₁₉H₂₀N₂O₃
• 分子量: 324.379
• InChiKey: YRINCQQVWGPJRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  70.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-butyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one 、 5-chloro-1-ethylindoline-2,3-dione 、 2-乙酰基吡啶 生成 5-chloro-1-ethyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one
  参考文献：
  名称：

  Isatin compounds, compositions and methods for treatment of degenerative diseases and disorders

  摘要：

  本文提供的化合物具有以下公式（I）： 其中取代基如规范中所披露的那样，以及其药学上可接受的盐。这些化合物以及含有它们的药物组合物，对于治疗退行性疾病和疾患是有用的。

  公开号：

  US09079853B2
• 作为产物：
  描述：

  2-乙酰基吡啶 、 1-丁基-1H-吲哚-2,3-二酮 在 二甲胺 作用下， 以 甲醇 、 水 为溶剂， 以80%的产率得到1-butyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one
  参考文献：
  名称：

  US2014/275075

  摘要：

  公开号：

文献信息

• Isatin compounds, compositions and methods for treatment of degenerative diseases and disorders
  申请人：MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

  公开号：US09079853B2

  公开（公告）日：2015-07-14

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

  本文提供的化合物具有以下公式（I）： 其中取代基如规范中所披露的那样，以及其药学上可接受的盐。这些化合物以及含有它们的药物组合物，对于治疗退行性疾病和疾患是有用的。
• US20140275075A1
  申请人：——

  公开号：——

  公开（公告）日：——
• ISATIN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS
  申请人：Musc Foundation for Research Development

  公开号：EP2970183A2

  公开（公告）日：2016-01-20
• Compositions and Methods for the Treatment of Degenerative Diseases
  申请人：Beeson Craig Cano

  公开号：US20130137728A1

  公开（公告）日：2013-05-30

  Disclosed are compounds or pharmaceutically acceptable salts thereof, having the structure of formula I. Also disclosed are methods of preventing and/or treating degenerative disease in a subject, comprising administering to said subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions for preventing and/or treating de-generative disease in a subject comprising a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof.
• COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS
  申请人：MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

  公开号：US20160237074A1

  公开（公告）日：2016-08-18

  Disclosed are compounds or pharmaceutically acceptable salts thereof, having the structure of formula I. Also disclosed are methods of preventing and/or treating degenerative disease in a subject, comprising administering to said subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions for preventing and/or treating degenerative disease in a subject comprising a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof.