1-(4-Nitrophenyl)-2-[3-[2-(4-nitrophenyl)-2-oxoethyl]imidazol-3-ium-1-yl]ethanone;bromide | 77234-62-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-Nitrophenyl)-2-[3-[2-(4-nitrophenyl)-2-oxoethyl]imidazol-3-ium-1-yl]ethanone;bromide
• CAS: 77234-62-9
• 化学式: Br*C₁₉H₁₅N₄O₆
• 分子量: 475.255
• InChiKey: SZACRYCPARIKAH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.64
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  135
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-溴-4'-硝基苯乙酮 、 咪唑 生成 1-(4-Nitrophenyl)-2-[3-[2-(4-nitrophenyl)-2-oxoethyl]imidazol-3-ium-1-yl]ethanone;bromide
  参考文献：
  名称：

  NARDI, D.;TAJANA, A.;LEONARDI, A.;PENNINI, R.;PORTIOLI, F.;MAGISTRETTI, M+, J. MED. CHEM., 1981, 24, N 6, 727-731

  摘要：

  DOI：

文献信息

• An Efficient and Convenient Method for Synthesis of 1-Substituted Imidazoles
  作者：Fung Fuh Wong、Chun Min Lin、Jiann-Jyh Huang、Mou-Yung Yeh

  DOI：10.3987/com-06-10726

  日期：——
• Salerno; Sorrenti; Guerrera, Pharmazie, 1999, vol. 54, # 9, p. 685 - 690
  作者：Salerno、Sorrenti、Guerrera、Sarva、Siracusa、Di Giacomo、Vanella

  DOI：——

  日期：——
• Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(.omega.-phenyl-.omega.-hydroxyalkyl)imidazoles
  作者：Dante Nardi、Alberto Tajana、Amedeo Leonardi、Renzo Pennini、Ferruccio Portioli、Maria Jose Magistretti、Alessandro Subissi

  DOI：10.1021/jm00138a017

  日期：1981.6

  A novel series of N-(benzoylalkyl)imidazoles and N-(omega-phenyl-omega-hydroxyalkyl)imidazoles was synthesized and evaluated for anticonvulsant activity in mice against maximal electroshock induced seizures. Some of the compounds showed an activity comparable to or better than phenytoin and phenobarbital. The N-[beta-[4-(beta-phenylethyl)phenyl]-beta-hydroxyethyl]imidazole (38) was selected for further studies; preclinical toxicology and additional efficacy evaluations are in progress. Structure-activity relationships are discussed.
• Imidazolium salts, intermediates thereto and their use
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：EP0131302B1

  公开（公告）日：1992-01-29
• NARDI, D.;TAJANA, A.;LEONARDI, A.;PENNINI, R.;PORTIOLI, F.;MAGISTRETTI, M+, J. MED. CHEM., 1981, 24, N 6, 727-731
  作者：NARDI, D.、TAJANA, A.、LEONARDI, A.、PENNINI, R.、PORTIOLI, F.、MAGISTRETTI, M+

  DOI：——

  日期：——