2-苯基三唑-4-甲酰肼 | 62289-78-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-苯基三唑-4-甲酰肼
• 英文名称: 2-Phenyl-1.2.3-triazol-4-carbonsaeure-hydrazid
• 英文别名: 2-Phenyl-2H-1,2,3-triazole-4-carbohydrazide；2-phenyltriazole-4-carbohydrazide
• CAS: 62289-78-5
• 化学式: C₉H₉N₅O
• mdl: MFCD11643380
• 分子量: 203.203
• InChiKey: QHDPUJMCRUPKIE-UHFFFAOYSA-N

物化性质

• 熔点：
  175-176 °C(Solv: ethanol (64-17-5))
• 密度：
  1.45±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-苯基三唑-4-甲酰肼 以 二氯甲烷 为溶剂， 20.0 ℃ 、399.97 Pa 条件下， 生成 2-苯基-1,2,3-三唑-4-甲醛
  参考文献：
  名称：

  Trifluoromethanesulfonic Hydrazides

  摘要：

  We succeeded to observe at low temperature in reactions of trifluoromethanesulfonic anhydride and trifluoromethanesulfonyl chloride with hydrazine, phenyl hydrazine, and 1,1-dimethylhydrazine a formation of the corresponding trifluoromethanesulfonic hydrazides that at heating to room temperature decomposed liberating nitrogen and affording trifluoromethanesulfinic acid. 2-Phenyl-2H-1,2,3-triazole-4-carboxylic hydrazide reacted with trifluoromethanesulfonic anhydride to furnish trifluoro-N'-(2-phenyl-2H-1,2,3-triazol-4-ylcarbonyl)methanesulfonic hydrazide that decomposed at heating with elimination of trifluoromethanesulfinic acid and nitrogen yielding 2-phenyl-2H- 1,2,3-triazole-4-carbaldehyde.

  DOI：

  10.1023/b:rujo.0000045884.87574.ec
• 作为产物：
  描述：

  methyl 2-phenyl-2H-1,2,3-triazole-4-carboxylate 在 一水合肼 作用下， 反应 1.0h， 以90.7%的产率得到2-苯基三唑-4-甲酰肼
  参考文献：
  名称：

  Trifluoromethanesulfonic Hydrazides

  摘要：

  We succeeded to observe at low temperature in reactions of trifluoromethanesulfonic anhydride and trifluoromethanesulfonyl chloride with hydrazine, phenyl hydrazine, and 1,1-dimethylhydrazine a formation of the corresponding trifluoromethanesulfonic hydrazides that at heating to room temperature decomposed liberating nitrogen and affording trifluoromethanesulfinic acid. 2-Phenyl-2H-1,2,3-triazole-4-carboxylic hydrazide reacted with trifluoromethanesulfonic anhydride to furnish trifluoro-N'-(2-phenyl-2H-1,2,3-triazol-4-ylcarbonyl)methanesulfonic hydrazide that decomposed at heating with elimination of trifluoromethanesulfinic acid and nitrogen yielding 2-phenyl-2H- 1,2,3-triazole-4-carbaldehyde.

  DOI：

  10.1023/b:rujo.0000045884.87574.ec

文献信息

• A Novel 2-Phenyl-1,2,3-Triazole Derived Fluorescent Probe for Recyclable Detection of Al3+ in Aqueous Medium and Its Application
  作者：Zhengfeng Xie、Yunpeng Hao、Zhen Li、Fanghua Sun、Junchi Ma、Xin Chen、Wei Shi、Shun Feng

  DOI：10.1134/s1068162020040214

  日期：2020.7

  of HPTC with Al 3+ and the detection limit of HPTC toward Al 3+ were 1.67 × 10 5 M –1 and 8.875 × 10 –8 M, respectively. In addition, the probe HPTC can detect Al 3+ repeatedly in DMSO/Tris-HCl (pH 7.4) 1 : 100 v/v and the detection effect is not changed. The probe HPTC showed an excellent detection ability in a wide pH range from 3 to 10 and also in living cells. Furthermore, the Al 3+ sensing mechanism

  Abstrast——设计并合成了一种新型2-苯基-1,2,3-三唑衍生荧光探针HPTC（(2-hydroxybenzylidene)-2-phenyl-2 H -1,2,3-triazole-4-carbohydrazide）用于 DMSO/Tris-HCl (pH 7.4) 1 : 100 v/v 中 Al 3+ 的可回收检测，具有高灵敏度和选择性。添加 10.0 当量后，可在 457 nm 处实现 97 倍的荧光增强。Al 3+ 激发波长为 375 nm。HPTC 与Al 3+ 的结合常数和HPTC 对Al 3+ 的检测限分别为1.67 × 10 5 M –1 和8.875 × 10 –8 M。此外，探针HPTC可以在DMSO/Tris-HCl (pH 7.4) 1 : 100 v/v 中重复检测Al 3+ 且检测效果不变。HPTC 探针在 3 到 10 的宽 pH 范围内以及在活细胞中均显示出出色的检测能力。此外，Al
• Toldy et al., Acta Chimica Academiae Scientiarum Hungaricae, 1954, vol. 4, p. 303,307
  作者：Toldy et al.

  DOI：——

  日期：——
• ——
  作者：L. Tsao、V. Van、G. Sun、Yu. Lyu

  DOI：10.1023/a:1012369621168

  日期：——

  A general procedure was proposed for the synthesis of 3-(5-aryl-1,3,4-oxadiazol-2-yl)chromones by reaction of 3-formylchromone with aroylhydrazines, transformation of the corresponding acylhydrazones into 1,3-dipoles by the action of bromine in the presence of sodium acetate, and intramolecular ring closure.
• Synthesis of 3-(5-Aryl-1,3,4-oxadiazol-2-yl)chromones
  作者：L. Cao、W. Wang

  DOI：10.1023/b:cohc.0000003526.98678.6e

  日期：2003.8