N'-[(1E)-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-methylbenzohydrazide | 1246847-95-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N'-[(1E)-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-methylbenzohydrazide
• 英文别名: N-[(E)-(5-chloro-3-methyl-1-phenylpyrazol-4-yl)methylideneamino]-4-methylbenzamide
• CAS: 1246847-95-9
• 化学式: C₁₉H₁₇ClN₄O
• 分子量: 352.823
• InChiKey: UYELZUDQVMJDNL-CIAFOILYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  59.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-氯-3-甲基-1-苯基吡唑-4-甲醛 、 对甲苯甲酰肼 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 以78%的产率得到N'-[(1E)-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-methylbenzohydrazide
  参考文献：
  名称：

  N’-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides: Synthesis and anticonvulsant activity

  摘要：

  A series of N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides were synthesized using appropriate synthetic route and characterized by elemental analysis and spectral data. The anticonvulsant activity of some of the synthesized compounds were evaluated against maximal electroshock induced seizure (MES) and subcutaneous pentylenetetrazol (scPTZ) induced seizure models in mice. The neurotoxicity were assessed using the rotorod method. All the test compounds were administered at doses of 30,100, and 300 mg/kg body weight and the anticonvulsant activity was noted at 0.5 and 4 h time intervals after the drug administration. Among the compound tested, all except 5g showed protection from seizures in both the animal models. Some titled compounds exhibited lesser CNS depression and neurotoxicity compared to phenytoin. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.049

文献信息

• N’-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides: Synthesis and anticonvulsant activity
  作者：Darpan Kaushik、Suroor Ahmad Khan、Gita Chawla、Suresh Kumar

  DOI：10.1016/j.ejmech.2010.05.049

  日期：2010.9

  A series of N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides were synthesized using appropriate synthetic route and characterized by elemental analysis and spectral data. The anticonvulsant activity of some of the synthesized compounds were evaluated against maximal electroshock induced seizure (MES) and subcutaneous pentylenetetrazol (scPTZ) induced seizure models in mice. The neurotoxicity were assessed using the rotorod method. All the test compounds were administered at doses of 30,100, and 300 mg/kg body weight and the anticonvulsant activity was noted at 0.5 and 4 h time intervals after the drug administration. Among the compound tested, all except 5g showed protection from seizures in both the animal models. Some titled compounds exhibited lesser CNS depression and neurotoxicity compared to phenytoin. (C) 2010 Elsevier Masson SAS. All rights reserved.