{4-[(2-Oxo-tetrahydro-furan-3-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester | 860495-51-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: {4-[(2-Oxo-tetrahydro-furan-3-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[4-[(2-oxooxolan-3-yl)methylamino]butyl]carbamate
• CAS: 860495-51-8
• 化学式: C₁₄H₂₆N₂O₄
• 分子量: 286.371
• InChiKey: GTFWVCLYGPEHKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  {4-[(2-Oxo-tetrahydro-furan-3-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester 、 二碳酸二叔丁酯 以 二氯甲烷 为溶剂， 反应 20.0h， 以89%的产率得到{4-[tert-Butoxycarbonyl-(2-oxo-tetrahydro-furan-3-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis of a Laterally Branched Polyamine from α-Methylene-γ-butyrolactone

  摘要：

  A polyamine derivative was prepared from alpha-methylene-gamma-butyrolactone. This method used Michael addition and lactone aminolysis followed by the nucleophilic substitution of the hydroxyl group by an azido group. The coupling of a lipophilic alkyne led to a polyamine that will be probed as a gene transfer agent.

  DOI：

  10.1021/ol050803x
• 作为产物：
  描述：

  2-甲烯基丁内酯 、 N-叔丁氧羰基-1,4-丁二胺 以 乙醇 为溶剂， 反应 5.0h， 以76%的产率得到{4-[(2-Oxo-tetrahydro-furan-3-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis of a Laterally Branched Polyamine from α-Methylene-γ-butyrolactone

  摘要：

  A polyamine derivative was prepared from alpha-methylene-gamma-butyrolactone. This method used Michael addition and lactone aminolysis followed by the nucleophilic substitution of the hydroxyl group by an azido group. The coupling of a lipophilic alkyne led to a polyamine that will be probed as a gene transfer agent.

  DOI：

  10.1021/ol050803x

文献信息

• Synthesis of a Laterally Branched Polyamine from α-Methylene-γ-butyrolactone
  作者：Mickaël Jean、Myriam Le Roch、Jacques Renault、Philippe Uriac

  DOI：10.1021/ol050803x

  日期：2005.6.1

  A polyamine derivative was prepared from alpha-methylene-gamma-butyrolactone. This method used Michael addition and lactone aminolysis followed by the nucleophilic substitution of the hydroxyl group by an azido group. The coupling of a lipophilic alkyne led to a polyamine that will be probed as a gene transfer agent.