1,9-bis(aminooxy)nonane | 1219935-26-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,9-bis(aminooxy)nonane
• 英文别名: O,O'-(Nonane-1,9-diyl)bis(hydroxylamine)；O-(9-aminooxynonyl)hydroxylamine
• CAS: 1219935-26-8
• 化学式: C₉H₂₂N₂O₂
• 分子量: 190.286
• InChiKey: GUFADEVUEQECSC-UHFFFAOYSA-N

物化性质

• 沸点：
  324.2±15.0 °C(Predicted)
• 密度：
  0.965±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  70.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,9-bis(aminooxy)nonane 、 5-溴水杨醛 以 乙醇 为溶剂， 反应 6.0h， 以69.1%的产率得到4,4'-dibromo-2,2'-[(nonane-1,9-diyldioxy)bis(nitrilomethylidyne)]diphenol
  参考文献：
  名称：

  Bromo-Substituted Salamo-Type Compounds Possessing More Flexible O-Alkyl Chain: Synthesis and Sructural Characterization

  摘要：

  通过5-溴-2-羟基苯甲醛与1,7-双（氨基氧基）庚烷、1,8-双（氨基氧基）辛烷、1,9-双（氨基氧基）壬烷或1,10-双（氨基氧基）癸烷在热乙醇介质中的反应，分别合成了溴代萨拉莫型化合物系列，并通过元素分析、红外光谱、紫外-可见光谱和1H NMR光谱进行了表征。

  DOI：

  10.14233/ajchem.2014.17390
• 作为产物：
  描述：

  在 一水合肼 作用下， 生成 1,9-bis(aminooxy)nonane
  参考文献：
  名称：

  Synthesis and Characterization of Tetrahalogen Substituted Salamo-type Bisoximes Possessing More Flexible O-Alkyl Chain

  摘要：

  在乙醇介质中，分别由3-溴-5-氯-2-羟基苯甲醛和1,7-双（氨基氧基）庚烷、1,8-双（氨基氧基）辛烷、1,9-双（氨基氧基）壬烷或1,10-双（氨基氧基）癸烷合成了四种四卤代萨拉莫型双肟H2L1-H2L4，并通过元素分析以及红外光谱、紫外可见光谱和1H NMR光谱对其进行了表征。与萨伦部分相比，萨拉莫型双肟化合物对于组装超分子系统更有用。

  DOI：

  10.14233/ajchem.2014.16034

文献信息

• [EN] COMPOUNDS AND USES FOR THE TREATMENT AND PREVENTION OF DISEASES AND CONDITIONS ASSOCIATE WITH OR AGGRAVATED BY IMPARED MITOPHAGY<br/>[FR] COMPOSÉS ET UTILISATIONS POUR LE TRAITEMENT ET LA PRÉVENTION DE MALADIES ET D'ÉTATS ASSOCIÉS À UNE MITOPHAGIE DÉFICIENTE OU AGGRAVÉS PAR CELLE-CI
  申请人：YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD

  公开号：WO2019175873A1

  公开（公告）日：2019-09-19

  The present invention provides compounds and methods for the treatment and prevention of diseases and conditions associate with or aggravated by impaired mitophagy.

  本发明提供了用于治疗和预防与受损线粒体自噬有关或由其恶化的疾病和病况的化合物和方法。
• Synthesis and Characterization of Four New Chloro-Group Substituted Salamo-Type Bisoxime Compounds
  作者：Ruo-Yan Li、Li Jing、Jiao-Long Meng、Gang Li

  DOI：10.14233/ajchem.2014.16295

  日期：——

  A series of chloro-substituted Salamo-type bisoxime compounds 4,4,6,6-tetrachloro-2.2-[(1,7-heptanediyldioxy)bis(nitrilomethylidyne)] diphenol (H2L1), 4,4,6,6-tetrachloro-2.2-[(1,8-octanediyldioxy)bis(nitrilomethylidyne)]diphenol (H2L2), 4,4,6,6-tetrachloro-2.2-[(1,9-nonanediyldioxy)bis(nitrilomethylidyne)]diphenol (H2L3) and 4,4,6,6-tetrachloro-2.2-[(1,10-decanediyldioxy)bis(nitrilomethylidyne)]diphenol (H2L4) have been synthesized and characterized by elemental analyses, IR spectra, UV-visible and 1H NMR spectroscopy. The chloro-group substitutied salamo-type bisoxime compounds H2L1-H2L4 may be a promising units for the construction of supramolecular complexes.

  一系列氯代萨拉莫型双肟化合物 4,4,6,6-tetrachloro-2.2-[(1,7-heptanediyldioxy)bis(nitrilomethidyne)] diphenol (H2L1)、4,4,6,6-tetrachloro-2.2-[(1,8-辛二基二氧基)双(次氮基亚甲基)]二苯酚 (H2L2)、4,4,6,6-四氯-2.合成了 2-[(1,9-壬二氧基)双(次氮基亚甲基)]二苯酚 (H2L3) 和 4,4,6,6-四氯-2.2-[(1,10-癸二氧基)双(次氮基亚甲基)]二苯酚 (H2L4)，并通过元素分析、红外光谱、紫外可见光和 1H NMR 光谱进行了表征。氯基取代的水杨醛型双肟化合物 H2L1-H2L4 可能是构建超分子复合物的理想单元。
• Synthesis and Characterization of Series of Methoxy-Substituted Salamo-Type Compounds Having More Flexible O-Alkyl Chain
  作者：Xiu-Yan Dong、Su-Xia Gao、Yu-Jie Zhang、Yang Zhang、Li Wang

  DOI：10.14233/ajchem.2014.17417

  日期：——

  Several novel methoxy-substituted Salamo-type compounds have been synthesized by the condensation reactions of 3-methoxy-2-hydroxy-benzaldehyde with 1,7-bis(aminooxy)heptane, 1,8-bis(aminooxy)octane, 1,9-bis(aminooxy)nonane or 1,10-bis(aminooxy)decane in ethanol medium, respectively and characterized by elemental analyses, IR, UV-visible and 1H NMR spectra.

  在乙醇介质中，通过 3-甲氧基-2-羟基苯甲醛与 1,7-双（氨基氧基）庚烷、1,8-双（氨基氧基）辛烷、1,9-双（氨基氧基）壬烷或 1,10- 双（氨基氧基）癸烷的缩合反应，分别合成了几种新型甲氧基取代的萨拉莫型化合物，并通过元素分析、红外光谱、紫外可见光谱和 1H NMR 光谱对其进行了表征。
• Synthesis and Characterization of Salamo-Type Bisoxime Compounds Based on 2-Hydroxy-4-methoxybenzaldehyde and Bis(aminooxy)alkane
  作者：Li Wang、Wei-Min Zhou、Gang Li、Yang Zhang

  DOI：10.14233/ajchem.2014.17568

  日期：——

  Three new Salamo-type bisoxime compounds H2L1-H2L3 have been synthesized from 2-hydroxy-4-methoxybenzaldehyde and 1,5-bis(aminooxy)pentane, 1,6-bis(aminooxy)hexane or 1,9-bis(aminooxy)nonane in hot ethanol medium, respectively and characterized by elemental analysis, IR and 1H NMR spectroscopy.

  三种新的Salamo型双肟化合物H2L1-H2L3分别由2-羟基-4-甲氧基苯甲醛和1,5-双(氨基氧基)戊烷、1,6-双(氨基氧基)己烷或1,9-双(氨基氧基)壬烷在热乙醇介质中合成，并通过元素分析、红外光谱和1H NMR光谱进行了表征。
• A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH
  作者：Fa Liu、Ramin Mollaaghababa Hakami、Beverly Dyas、Medhanit Bahta、George T. Lountos、David S. Waugh、Robert G. Ulrich、Terrence R. Burke

  DOI：10.1016/j.bmcl.2010.03.058

  日期：2010.5

  A bivalent tethered approach toward YopH inhibitor development is presented that joins aldehydes with mixtures of bis-aminooxy-containing linkers using oxime coupling. The methodology is characterized by its facility and ease of use and its ability to rapidly identify low micromolar affinity inhibitors. The generality of the approach may potentially make it amenable to the development of bivalent inhibitors directed against other phosphatases. Published by Elsevier Ltd.