3-(2-ethoxy-ethyl)-pentane-2,4-dione | 5185-96-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-ethoxy-ethyl)-pentane-2,4-dione
• 英文别名: 3-(2-Aethoxy-aethyl)-pentan-2,4-dion；Aethyl-(3.3-diacetyl-propyl)-aether；3-(2-Aethoxy-aethyl)-acetylaceton；3-(2-Ethoxyethyl)pentane-2,4-dione；3-(2-ethoxyethyl)pentane-2,4-dione
• CAS: 5185-96-6
• 化学式: C₉H₁₆O₃
• 分子量: 172.224
• InChiKey: BXLBDMTXCOECFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-iodoethyl ethyl ether 、 pentane-2,4-dione sodium salt 以 1,4-二氧六环 为溶剂， 生成 3-(2-ethoxy-ethyl)-pentane-2,4-dione
  参考文献：
  名称：

  The Reaction of Oxymercurials with Active Methylene Compounds and the Demercuration of the Resulting Mercurials with Acid and Base

  摘要：

  DOI：

  10.1021/jo01340a023

文献信息

• Maintenance of Mydriasis with One Bolus of Epinephrine Injection During Phacoemulsification
  作者：Shiow-Wen Liou、Chun-Chen Chen

  DOI：10.1089/108076801750295281

  日期：2001.6

  Surgically-induced miosis commonly occurs during cataract extraction surgery, complicating removal of lens cortex and placement of a posterior chamber intraocular lens. To maintain intraoperative mydriasis, one bolus of epinephrine injection was used in our study. The pupillary response to various doses of intracameral epinephrine (0.1 mi of 1:25,000, 1:50,000, 1:100,000, 1:200,000, 1:400,000) was assessed in 60 consecutive patients. The pupil size was measured just prior to the incision, one min after epinephrine injection, after phacoemulsification and after irrigation/aspiration. There was no significant difference among the mean mydriatic responses to the epinephrine concentrations we tested. The 1:400,000 concentration appeared to be as effective as 1:25,000, but two cases of the 1:400,000 group failed to maintain the pupil diameter after irrigation/aspiration. In addition, we found that blood pressure did not elevate after injection of any concentration of epinephrine. We concluded that one bolus of an extremely dilute concentration of epinephrine (i.e., 1:400,000) injection might be effective in maintaining mydriasis during cataract surgery without systemic side effects.
• The Reaction of Oxymercurials with Active Methylene Compounds and the Demercuration of the Resulting Mercurials with Acid and Base
  作者：Katsuhiko Ichikawa、Osamu Itoh、Takahisa Kawamura、Mutsuzo Fujiwara、Tamotsu Ueno

  DOI：10.1021/jo01340a023

  日期：1966.2