(R)-5-isopropylpyrrolidine-2,4-dione | 848420-60-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-5-isopropylpyrrolidine-2,4-dione
• 英文别名: (R)-5-Isopropyl-pyrrolidine-2,4-dione；(5R)-5-propan-2-ylpyrrolidine-2,4-dione
• CAS: 848420-60-0
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: PLFGCAPFRIWBQU-SSDOTTSWSA-N

物化性质

• 沸点：
  325.7±35.0 °C(Predicted)
• 密度：
  1.087±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氨 、 (R)-5-isopropylpyrrolidine-2,4-dione 、 ethyl-3-amino-5-(4-fluorophenyl)-2-pentenoate 、 4-formyl-N-furan-2-ylmethylbenzamide 在 氩 、 crude product 、 silica gel 、 二氯甲烷 作用下， 以 乙醇 为溶剂， 反应 17.0h， 以yielding the title compound (77 mg, 22% yield)的产率得到2-[2-(4-fluoro-phenyl)-ethyl]-4-{4-[(furan-2-ylmethyl)-carbamoyl]phenyl}-7-isopropyl-5-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Modulators of calcitonin and amylin activity

  摘要：

  在多个方面，本发明涉及新颖化合物，该化合物调节降钙素和淀粉样蛋白受体的活性；制备此类化合物的方法；以及包括此类化合物的制药组合物。本发明的化合物可用作降钙素和/或淀粉样蛋白激动剂，并用于骨疾病的治疗，如骨质疏松症、帕吉特病、高钙血症，以及代谢性疾病的治疗，如需要胰岛素的状态。

  公开号：

  US20070088163A1
• 作为产物：
  描述：

  1-Butoxycarbonyl-2-Isopropyl-3,5-dioxo-pyrrolidine 以 trifluoracetic acid-dichloromethane 为溶剂， 反应 0.5h， 以to give the title compound (0.99 mg, quantitative, contains one equivalent of TFA) as a pale yellow oil which的产率得到(R)-5-isopropylpyrrolidine-2,4-dione
  参考文献：
  名称：

  Modulators of calcitonin and amylin activity

  摘要：

  在多个方面，本发明涉及新颖化合物，该化合物调节降钙素和淀粉样蛋白受体的活性；制备此类化合物的方法；以及包括此类化合物的制药组合物。本发明的化合物可用作降钙素和/或淀粉样蛋白激动剂，并用于骨疾病的治疗，如骨质疏松症、帕吉特病、高钙血症，以及代谢性疾病的治疗，如需要胰岛素的状态。

  公开号：

  US20070088163A1

文献信息

• SmI₂-Mediated Coupling of Nitrones and <i>tert</i>-Butanesulfinyl Imines with Allenoates: Synthesis of β-Methylenyl-γ-lactams and Tetramic Acids
  作者：Chu-Pei Xu、Pei-Qiang Huang、Sandrine Py

  DOI：10.1021/ol300550x

  日期：2012.4.20

  Nitrones and tert-butanesulfinyl imines undergo conjugate addition to alkyl allenoates under SmI2-mediated reductive coupling conditions to produce novel beta-methylenyl-substituted gamma-amino esters. The latter were readily transformed into the corresponding beta-methylenyl-gamma-lactams by simple zinc reduction (N-hydroxy amines) or by acid hydrolysis (sulfinamides). The diastereoselective preparation of various beta-methylenyl-gamma-lactams offers a route to tetramic acids, the key structural features of an important class of bioactive natural products.
• [EN] MODULATORS OF CALCITONIN AND AMYLIN ACTIVITY<br/>[FR] MODULATEURS DE L'ACTIVITE DE LA CALCITONINE ET DE L'AMYLINE
  申请人：KEMIA INC

  公开号：WO2005025504A2

  公开（公告）日：2005-03-24

  In various aspects, the present invention relates to novel compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of such compounds; and to pharmaceutical compositions including such compounds. Compounds of the invention are useful as calcitonin and/or amylin agonists and in the treatment of bone disease such as osteoporosis, Paget's disease, hypercalcemia, and in the treatment of metabolic diseases, such as insulin-requiring states.
• Modulators of calcitonin and amylin activity
  申请人：Pryor Kent

  公开号：US20070088163A1

  公开（公告）日：2007-04-19

  In various aspects, the present invention relates to novel compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of such compounds; and to pharmaceutical compositions including such compounds. Compounds of the invention are useful as calcitonin and/or amylin agonists and in the treatment of bone disease such as osteoporosis, Paget's disease, hypercalcemia, and in the treatment of metabolic diseases, such as insulin-requiring states.

  在多个方面，本发明涉及新颖化合物，该化合物调节降钙素和淀粉样蛋白受体的活性；制备此类化合物的方法；以及包括此类化合物的制药组合物。本发明的化合物可用作降钙素和/或淀粉样蛋白激动剂，并用于骨疾病的治疗，如骨质疏松症、帕吉特病、高钙血症，以及代谢性疾病的治疗，如需要胰岛素的状态。