methyl 2-(hydroxy(furan-2-yl)methyl)oxirane-2-carboxylate | 1343488-04-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: methyl 2-(hydroxy(furan-2-yl)methyl)oxirane-2-carboxylate
• 英文别名: Methyl 2-[furan-2-yl(hydroxy)methyl]oxirane-2-carboxylate；methyl 2-[furan-2-yl(hydroxy)methyl]oxirane-2-carboxylate
• CAS: 1343488-04-9
• 化学式: C₉H₁₀O₅
• 分子量: 198.175
• InChiKey: WGALOLVQNABXQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  72.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-羟基-2-亚甲基-3-(2-呋喃基)丙酸甲酯 在 titanium(IV) isopropylate 、 叔丁基过氧化氢 、 L-(+)-酒石酸二乙酯 作用下， 以 二氯甲烷 为溶剂， 以76%的产率得到methyl 2-(hydroxy(furan-2-yl)methyl)oxirane-2-carboxylate
  参考文献：
  名称：

  Synthesis, antitubercular and antifungal activities of heteroaryl-substituted oxiranes derived from Baylis–Hillman adducts

  摘要：

  A series of heteroaryl-substituted oxiranes (2a-2f) were synthesized in good yields by epoxidation of Baylis-Hillman adducts (1a-1f). The title compounds were evaluated for their invitro antifungal and antitubercular activities at various concentrations.

  DOI：

  10.1007/s00044-011-9802-2

文献信息

• Synthesis, antitubercular and antifungal activities of heteroaryl-substituted oxiranes derived from Baylis–Hillman adducts
  作者：Shubha Jain、Neelaiah Babu、Srinivasa Rao Jetti、Harshada Shah、Surya Prakash Dhaneria

  DOI：10.1007/s00044-011-9802-2

  日期：2012.10

  A series of heteroaryl-substituted oxiranes (2a-2f) were synthesized in good yields by epoxidation of Baylis-Hillman adducts (1a-1f). The title compounds were evaluated for their invitro antifungal and antitubercular activities at various concentrations.