2-苯胺基-5-硝基噻唑 | 21166-17-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-苯胺基-5-硝基噻唑
• 英文名称: (5-nitro-thiazol-2-yl)-phenyl-amine
• 英文别名: N-<5-Nitrothiazolyl-(2)>anilin；2-Anilino-5-nitrothiazole；5-nitro-N-phenyl-1,3-thiazol-2-amine
• CAS: 21166-17-6
• 化学式: C₉H₇N₃O₂S
• 分子量: 221.239
• InChiKey: WAXMJNXACVJJDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2934100090

反应信息

• 作为产物：
  描述：

  2-溴-5-硝基噻唑 、 苯胺 以 二甲基亚砜 为溶剂， 生成 2-苯胺基-5-硝基噻唑
  参考文献：
  名称：

  硝噻唑的开环†

  摘要：

  已经研究了2-卤代5-硝基-噻唑与胺之间的反应。特别是在空间上受阻的强碱性仲脂族胺趋于引起噻唑环系统的打开，导致形成迄今未知的（1-硝基-2-氨基-乙烯基）-硫氰酸酯。高极性溶剂如二甲基亚砜有利于开环。提出了一种简单的反应机理，并讨论了这些新化合物的一些性质。

  DOI：

  10.1002/hlca.19680510729

文献信息

• [EN] BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS<br/>[FR] DERIVES DE L'ACIDE BENZOYL-AMINO-PYRIDYL-CARBOXYLIQUE UTILES EN TANT QU'ACTIVATEURS DE LA GLUCOKINASE (GLK)
  申请人：ASTRAZENECA AB

  公开号：WO2005056530A1

  公开（公告）日：2005-06-23

  A compound of Formula (I): Formula (I) wherein: R1 is selected from hydrogen and C1-4alkyl; R2 is selected from: R4-C(R5aR5b)- , R4=C(R6)- and R7aC(R7b)=C(R6)-; R3 X- is selected from methyl, methoxymethyl and ; R4 is selected from (optionally substituted) C1-4alkyl, phenyl, C3-6cycloalkyl and heteroaryl; R5a and R5b are independently selected from hydrogen, fluoro and C1-4alkyl; R6 is selected from hydrogen and C1-4alkyl; R7a and R7b are optionally substituted C1-4alkyl; or a salt, pro-drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

  化合物的化学式（I）：化学式（I）其中：R1选择氢和C1-4烷基; R2选择自R4-C（R5aR5b）-，R4=C（R6）-和R7aC（R7b）=C（R6）-; R3X-选择甲基，甲氧甲基和; R4选择（可选取代）C1-4烷基，苯基，C3-6环烷基和杂环芳基; R5a和R5b独立选择氢，氟和C1-4烷基; R6选择氢和C1-4烷基; R7a和R7b是可选取代的C1-4烷基; 或其盐，前药或溶剂。描述了它们作为GLK激活剂的用途，包含它们的制药组合物以及它们的制备方法。
• [EN] BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS<br/>[FR] DERIVES D'ACIDE BENZOYL-AMINO-PYRIDYL-CARBOXYLIQUE UTILISES EN TANT QU'ACTIVATEURS DE LA GLUCOKINASE (GLK)
  申请人：ASTRAZENECA AB

  公开号：WO2005054200A1

  公开（公告）日：2005-06-16

  Compounds of Formula: (I); wherein: R¹ is selected from: fluoro, chloro, C1-3alkyl and C1-3alkoxy; R²-X- is selected from: methyl, methoxymethyl and Formula: (X); n is 0,1 or 2; or a salt, pro-drug or solvate thereof are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

  式化合物：(I)；其中：R¹选择自：氟、氯、C1-3烷基和C1-3烷氧基；R²-X-选择自：甲基、甲氧甲基和式：(X)；n为0、1或2；或其盐、前药或溶剂化合物。描述了它们作为GLK激活剂的用途，含有它们的药物组合物，以及它们的制备方法。
• [EN] PYRIDINE CARBOXYLIC ACID DERIVATIVES AS GLUCOKINASE MODULATORS<br/>[FR] DERIVES D'ACIDES CARBOXYLIQUE DE PYRIDINE EN TANT QUE MODULATEURS DE LA GLUCOKINASE
  申请人：ASTRAZENECA AB

  公开号：WO2005044801A1

  公开（公告）日：2005-05-19

  A compound of Formula (I): wherein: A is phenyl or a 5- or 6-membered heteroaryl ring, optionally substituted; R1 and R2 are selected from hydrogen and methyl; with the proviso that at least one of R1 and R2 is methyl; or a salt, pro-drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

  式(I)的化合物：其中：A为苯基或5-或6-成员杂环芳基环，可选择地取代；R1和R2从氢和甲基中选取；条件是R1和R2中至少有一个为甲基；或其盐、前药或溶剂化合物。描述了它们作为GLK激活剂的用途，含有它们的药物组合物以及它们的制备方法。
• [EN] BENZOYL AMINO PYRIDIL CARBOXYLIC ACID DERIVATIVES AS GLUOKINASE ACTIVATORS<br/>[FR] DERIVES D'ACIDE CARBOXYLIQUE BENZOYL-AMINO-PYRIDILES UTILISES COMME ACTIVATEURS DE GLUCOKINASE
  申请人：ASTRAZENECA AB

  公开号：WO2005054233A1

  公开（公告）日：2005-06-16

  Compounds of Formula (I) wherein: R1-X- is selected from: methyl, methoxymethyl and Formula (X); R2 is selected from hydrogen, methyl, chloro and fluoro; n is 1 or 2; or a salt, pro-drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

  公式（I）中的化合物，其中：R1-X-选自：甲基，甲氧甲基和公式（X）；R2选自氢，甲基，氯和氟；n为1或2；或其盐，前药或溶剂化合物。描述了它们作为GLK激活剂的用途，含有它们的药物组合物，以及它们的制备方法。
• METHODS OF TREATMENT OF CHOLESTASIS AND FIBROSIS
  申请人：GENFIT

  公开号：US20170290814A1

  公开（公告）日：2017-10-12

  The present invention relates compounds useful and their use for treating cholestatic and fibrotic diseases.

  本发明涉及有用的化合物及其用于治疗胆汁淤积和纤维化疾病的用途。