4-Methoxy-4-methylpent-1-ene | 60753-95-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Methoxy-4-methylpent-1-ene
• CAS: 60753-95-9
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: YYCOTHWDEPIJTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Methyl 2-phenyl-2-propyl peroxide 、 烯丙基三甲基硅烷 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以55%的产率得到4-Methoxy-4-methylpent-1-ene
  参考文献：
  名称：

  Selectivity in Lewis acid-mediated fragmentations of peroxides and ozonides: application to the synthesis of alkenes, homoallyl ethers, and 1,2-dioxolanes †

  摘要：

  二烷基过氧化物和臭氧化物的断裂强烈受到路易斯酸选择的影响。TiCl4促进叔过氧化物的C-O离子化（SN1反应），而SnCl4和BF3·OEt2促进O-O异裂（Hock反应）。阳离子中间体被烯丙基三甲基硅烷捕获，得到烯丙基化的烷烃和同烯丙基醚。在缺少亲核试剂的情况下，臭氧化物（1,2,4-三氧杂环戊烷）不可避免地发生O-O异裂。然而，烯丙基三甲基硅烷和SnCl4的组合导致通过捕获SN1离子化产生的中等体形成1,2-二氧杂环戊烷。

  DOI：

  10.1039/b001391i

文献信息

• Regiospecific allylation of acetals with allylsilanes catalyzed by iodotrimethylsilane. Synthesis of homoallylethers
  作者：Hideki Sakurai、Koshi Sasaki、Akira Hosomi

  DOI：10.1016/0040-4039(81)80140-2

  日期：1981.1

  Allylation of acetals with allylsilanes is catalyzed by iodotrimethylsilane to give the corresponding homoallyl ethers, with regiospecific transposition of the allyl group.

  缩醛与烯丙基硅烷的烯丙基化通过碘代三甲基硅烷催化，得到相应的均烯丙基醚，且烯丙基的区域特异性易位。
• 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES
  申请人：Galley Guido

  公开号：US20100029589A1

  公开（公告）日：2010-02-04

  The invention relates to compounds of formula I wherein R 1 , R 2 , X, Y, and n are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention also provides pharmaceutical compositions and methods of manufacture of such compounds. The compounds are useful for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases are depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

  该发明涉及公式I的化合物，其中R1、R2、X、Y和n在规范中定义，并且其药学上可接受的酸盐。该发明还提供了制备这种化合物的药物组合物和方法。这些化合物可用于治疗与痕量胺相关受体的生物功能相关的疾病，这些疾病包括抑郁症、焦虑症、躁郁症、注意缺陷多动障碍、与压力有关的疾病、精神疾病、精神分裂症、神经系统疾病、帕金森病、神经退行性疾病、阿尔茨海默病、癫痫、偏头痛、物质滥用和代谢紊乱、进食障碍、糖尿病、糖尿病并发症、肥胖症、脂质代谢异常、能量消耗和吸收异常、体温稳态异常、睡眠和昼夜节律异常、心血管疾病。
• Homogeneous catalysis. Use of the [TiCp2(CF3SO3)2] catalyst for the sakurai reaction of allylic silanes with orthoesters, acetals, ketals and carbonyl compounds.
  作者：T. Keith Hollis、N.P. Robinson、John Whelan、B. Bosnich

  DOI：10.1016/s0040-4039(00)79336-1

  日期：1993.7

  The effectiveness of the [TiCp2(CF3SO3)2] catalyst for the Sakurai reaction has been explored for a variety of allylic silanes reacting with orthoesters, acetals, ketals, aldehydes and ketones.

  对于与原酸酯，缩醛，缩酮，醛和酮反应的各种烯丙基硅烷，已经探索了[TiCp 2（CF 3 SO 3）2 ]催化剂在樱井反应中的有效性。
• ALLYLSILANES AS SYNTHETIC INTERMEDIATES. II. SYNTHESES OF HOMOALLYL ETHERS FROM ALLYLSILANES AND ACETALS PROMOTED BY TITANIUM TETRACHLORIDE
  作者：Akira Hosomi、Masahiko Endo、Hideki Sakurai

  DOI：10.1246/cl.1976.941

  日期：1976.9.5

  The reaction of allylsilanes with acetals in the presence of titanium tetrachloride afforded homoallyl ethers in good yields. The reaction took place regiospecifically with transposition of the allyl group.

  在四氯化钛的存在下，烯丙基硅烷与缩醛的反应以良好的产率得到高烯丙基醚。随着烯丙基的转座，反应发生区域特异性。
• SAKURAI HIDEKI; SASAKI KOSHI; HOSOMI AKIRA, TETRAHEDRON LETT., 1981, 22, NO 8, 745-748
  作者：SAKURAI HIDEKI、 SASAKI KOSHI、 HOSOMI AKIRA

  DOI：——

  日期：——