acetic acid-(3-propionyl-anilide) | 97111-27-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: acetic acid-(3-propionyl-anilide)
• 英文别名: 1-(3-Acetamino-phenyl)-propanon-(1)；Essigsaeure-(3-propionyl-anilid)；N-(3-propionylphenyl)acetamide；N-(3-propanoylphenyl)acetamide
• CAS: 97111-27-8
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: IOJFECVBVAXBCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  acetic acid-(3-propionyl-anilide) 在 Pd-BaSO₄ 、 高氯酸 、 溶剂黄146 作用下， 生成 3-丙基苯胺
  参考文献：
  名称：

  421的一些制备米-和p -alkylanilines

  摘要：

  DOI：

  10.1039/jr9530002066
• 作为产物：
  描述：

  3-氨基苯丙酮 生成 acetic acid-(3-propionyl-anilide)
  参考文献：
  名称：

  Keneford et al., Journal of the Chemical Society, 1948, p. 358,359

  摘要：

  DOI：

文献信息

• [EN] PRODUCTION OF N-ALKYLAMIDE COMPOUNDS<br/>[FR] PRODUCTION DE COMPOSES DE N-ALKYLAMIDE
  申请人：TAKASAGO PERFUMERY CO LTD

  公开号：WO2004087637A1

  公开（公告）日：2004-10-14

  The present invention provides an efficient process for the production of N-acylaniline derivatives by selectively alkylating an amide group at the nitrogen atom. The process comprises reacting an amide compound of the formula (2): (wherein, R1 and R2 are each independently an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an aryl group or a substituted aryl group) with a sulfuric acid ester in the presence of a solid metal hydroxide to give an N-alkylamide compound of the formula (3): (wherein R3 is an alkyl group and R1 and R2 have each the same meaning as described above).

  本发明提供了一种通过选择性地烷基化氮原子上的酰胺基团来生产N-酰苯胺衍生物的高效过程。该过程包括在固体金属羟基的存在下，将式（2）的酰胺化合物（其中，R1和R2分别独立地是烷基、取代烷基、烯基、取代烯基、芳基或取代芳基）与硫酸酯反应，得到式（3）的N-烷基酰胺化合物（其中R3是烷基，R1和R2的含义与上述相同）。
• halogen-substituted compounds
  申请人：Maue Michael

  公开号：US20110301181A1

  公开（公告）日：2011-12-08

  The invention relates to compounds of the general formula (I), in which the radicals A 1 , A 2 , A 3 , A 4 , Lm, Q, R 1 , T and U have the meaning given in the description and to the use of the compounds for controlling animal pests. In addition, the invention relates to processes and intermediates for the preparation of the compounds according to formula (I).

  该发明涉及一般式(I)的化合物，其中基团A1、A2、A3、A4、Lm、Q、R1、T和U的含义如描述中所示，以及该化合物用于控制动物害虫。此外，该发明涉及根据一般式(I)制备化合物的工艺和中间体。
• [EN] MALT1 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE MALT1 ET LEURS UTILISATIONS
  申请人：UNIV CORNELL

  公开号：WO2017040304A1

  公开（公告）日：2017-03-09

  Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin' s lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis,an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).

  本文提供了化合物的化学式(I)及其药物组合物，可用作MALT1抑制剂。还提供了通过给予化合物的化学式(I)来治疗增生性疾病（例如癌症（例如非霍奇金淋巴瘤、弥漫性大B细胞淋巴瘤、MALT淋巴瘤）、良性肿瘤、与血管生成有关的疾病、自身免疫疾病、炎症性疾病、自身炎症性疾病）的方法。
• HETERO RING DERIVATIVE
  申请人：Takahashi Fumie

  公开号：US20120165309A1

  公开（公告）日：2012-06-28

  [Object] A novel and excellent method for preventing or treating rejection in the transplantation of various organs, allergy diseases, autoimmune diseases, hematologic tumor, or the like, based on a PI3Kδ-selective inhibitory action and/or an IL-2 production inhibitory action, and/or a B cell proliferation inhibitory action (including an activation inhibitory action), is provided [Means for Solution] It was found that a 3-substituted triazine or 3-substituted pyrimidine derivative exhibits a PI3Kδ-selective inhibitory action, and/or an IL-2 production inhibitory action, and/or a B cell proliferation inhibitory action (including an activation inhibitory action), and can be an agent for preventing or treating rejection in the transplantation of various organs, allergy diseases (asthma, atopic dermatitis, etc.), autoimmune diseases (rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus, etc.), hematologic tumor (leukemia etc.), or the like, thereby completing the present invention.

  [目标]提供一种基于PI3Kδ选择性抑制作用和/或IL-2产生抑制作用和/或B细胞增殖抑制作用（包括激活抑制作用）的新颖优良方法，用于预防或治疗各种器官移植、过敏性疾病、自身免疫性疾病、血液肿瘤等的排斥反应。 [解决方案]发现3-取代-1,3,5-三嗪或3-取代嘧啶衍生物表现出PI3Kδ选择性抑制作用和/或IL-2产生抑制作用和/或B细胞增殖抑制作用（包括激活抑制作用），可以作为预防或治疗各种器官移植、过敏性疾病（哮喘、特应性皮炎等）、自身免疫性疾病（类风湿性关节炎、银屑病、溃疡性结肠炎、克罗恩病、系统性红斑狼疮等）、血液肿瘤（白血病等）等排斥反应的药物，从而完成了本发明。
• METHOD FOR PRODUCING ALKYLATED AROMATIC AMIDE DERIVATIVE
  申请人：Mitsui Chemicals Agro, Inc.

  公开号：US20150065721A1

  公开（公告）日：2015-03-05

  Provided is a method for producing an aromatic amide derivative represented by Formula (4), the method including a process in which an aromatic amide derivative represented by Formula (1) and a haloalkyl compound represented by Formula (3) are reacted with each other in the presence of a base and a metal or metal salt. In the formulae, each of X and Y represents a hydrogen atom, a halogen atom, or the like. A represents a hydrogen atom, an alkyl group, a group represented by Formula (2), or the like. Each of G 1 and G 2 represents an oxygen atom or the like. Q 1 represents a phenyl group or the like. R 1 represents a hydrogen atom, an alkyl group, or the like. Z 1 represents a haloalkyl group or the like. Xa represents an iodine atom or the like. m represents a number of from 1 to 4, n1 represents a number from 1 to 5, and n2 represents a number of from 1 to 4.

  提供的是一种制备由式（4）所表示的芳香酰胺衍生物的方法，该方法包括在碱和金属或金属盐的存在下，使由式（1）所表示的芳香酰胺衍生物和由式（3）所表示的卤代烷基化合物相互反应的过程。在式中，X和Y各自表示氢原子、卤素原子或类似物。A表示氢原子、烷基团、由式（2）表示的团或类似物。G1和G2各自表示氧原子或类似物。Q1表示苯基团或类似物。R1表示氢原子、烷基团或类似物。Z1表示卤代烷基团或类似物。Xa表示碘原子或类似物。m表示1到4的数字，n1表示1到5的数字，n2表示1到4的数字。