(2-Piperidin-1-yl-ethyl)-(7-trifluoromethyl-quinolin-4-yl)-amine | 289628-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (2-Piperidin-1-yl-ethyl)-(7-trifluoromethyl-quinolin-4-yl)-amine
• 英文别名: N-(2-piperidin-1-ylethyl)-7-(trifluoromethyl)quinolin-4-amine
• CAS: 289628-56-4
• 化学式: C₁₇H₂₀F₃N₃
• 分子量: 323.361
• InChiKey: FKKXOTPFSJAMSQ-UHFFFAOYSA-N

物化性质

• 沸点：
  444.2±45.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  28.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-(2-氨乙基)哌啶 、 4-氯-7-三氟甲基喹啉 以 乙醇 为溶剂， 以75%的产率得到(2-Piperidin-1-yl-ethyl)-(7-trifluoromethyl-quinolin-4-yl)-amine
  参考文献：
  名称：

  Novel Short Chain Chloroquine Analogues Retain Activity Against Chloroquine Resistant K1 Plasmodium falciparum

  摘要：

  A series of short chain chloroquine (CQ) derivatives have been synthesized in one step from readily available starting materials. The diethylamine function of CQ is replaced by shorter alkylamine groups (4-9) containing secondary or tertiary terminal nitrogens. Some of these derivatives are significantly more potent than CQ against a CQ resistant strain of Plasmodium falciparum in vitro. We conclude that the ability to accumulate at higher concentrations within the food vacuole of the parasite is an important parameter that dictates their potency against CQ sensitive and the chloroquine resistant K1 P. falciparum.

  DOI：

  10.1021/jm0108707

文献信息

• Novel Short Chain Chloroquine Analogues Retain Activity Against Chloroquine Resistant K1 <i>Plasmodium falciparum</i>
  作者：Paul A. Stocks、Kaylene J. Raynes、Patrick G. Bray、B. Kevin Park、Paul. M. O'Neill、Stephen A. Ward

  DOI：10.1021/jm0108707

  日期：2002.11.1

  A series of short chain chloroquine (CQ) derivatives have been synthesized in one step from readily available starting materials. The diethylamine function of CQ is replaced by shorter alkylamine groups (4-9) containing secondary or tertiary terminal nitrogens. Some of these derivatives are significantly more potent than CQ against a CQ resistant strain of Plasmodium falciparum in vitro. We conclude that the ability to accumulate at higher concentrations within the food vacuole of the parasite is an important parameter that dictates their potency against CQ sensitive and the chloroquine resistant K1 P. falciparum.