exo-5-norborneneamidomalonic acid diethyl ester | 1218026-61-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: exo-5-norborneneamidomalonic acid diethyl ester
• 英文别名: Diethyl 2-(bicyclo[2.2.1]hept-5-ene-2-carbonylamino)propanedioate
• CAS: 1218026-61-9
• 化学式: C₁₅H₂₁NO₅
• 分子量: 295.335
• InChiKey: WVGDXIANWYTNEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  exo-5-norborneneamidomalonic acid diethyl ester 在 potassium hydroxide 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Dynamics of Soft Nanomaterials Captured by Transmission Electron Microscopy in Liquid Water

  摘要：

  In this paper we present in situ transmission electron microscopy of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The nanoparticles studied were obtained from the direct polymerization of a Pt(II)-containing monomer. The resulting structures provided sufficient contrast for facile imaging in situ. We contend that this technique will quickly become essential in the characterization of analogous systems, especially where dynamics are of interest in the solvated state. We describe the preparation of the synthetic micellar nanoparticles together with their characterization and motion in liquid water with comparison to conventional electron microscopy analyses.

  DOI：

  10.1021/ja408513m
• 作为产物：
  描述：

  氨基丙二酸二乙酯盐酸盐 、 5-降冰片烯-2-羧酸 在 N-甲基吗啉 、 C₆H₉ClN₂O₂ 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以94%的产率得到exo-5-norborneneamidomalonic acid diethyl ester
  参考文献：
  名称：

  Dynamics of Soft Nanomaterials Captured by Transmission Electron Microscopy in Liquid Water

  摘要：

  In this paper we present in situ transmission electron microscopy of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The nanoparticles studied were obtained from the direct polymerization of a Pt(II)-containing monomer. The resulting structures provided sufficient contrast for facile imaging in situ. We contend that this technique will quickly become essential in the characterization of analogous systems, especially where dynamics are of interest in the solvated state. We describe the preparation of the synthetic micellar nanoparticles together with their characterization and motion in liquid water with comparison to conventional electron microscopy analyses.

  DOI：

  10.1021/ja408513m

文献信息

• Dynamics of Soft Nanomaterials Captured by Transmission Electron Microscopy in Liquid Water
  作者：Maria T. Proetto、Anthony M. Rush、Miao-Ping Chien、Patricia Abellan Baeza、Joseph P. Patterson、Matthew P. Thompson、Norman H. Olson、Curtis E. Moore、Arnold L. Rheingold、Christopher Andolina、Jill Millstone、Stephen B. Howell、Nigel D. Browning、James E. Evans、Nathan C. Gianneschi

  DOI：10.1021/ja408513m

  日期：2014.1.29

  In this paper we present in situ transmission electron microscopy of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The nanoparticles studied were obtained from the direct polymerization of a Pt(II)-containing monomer. The resulting structures provided sufficient contrast for facile imaging in situ. We contend that this technique will quickly become essential in the characterization of analogous systems, especially where dynamics are of interest in the solvated state. We describe the preparation of the synthetic micellar nanoparticles together with their characterization and motion in liquid water with comparison to conventional electron microscopy analyses.