2’-(乙酰基硫代)乙基2,3,4,6-四-O-乙酰基-beta-D-吡喃葡萄糖苷 | 34044-34-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2’-(乙酰基硫代)乙基2,3,4,6-四-O-乙酰基-beta-D-吡喃葡萄糖苷
• 中文别名: 2-(乙酰硫基)乙基2,3,4,6-四-O-乙酰基-Β-D-吡喃葡萄糖苷
• 英文名称: Acetic acid (2R,3R,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-(2-acetylsulfanyl-ethoxy)-tetrahydro-pyran-4-yl ester
• 英文别名: [(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(2-acetylsulfanylethoxy)oxan-2-yl]methyl acetate
• CAS: 34044-34-3
• 化学式: C₁₈H₂₆O₁₁S
• 分子量: 450.464
• InChiKey: GXVQXAUNYBLARZ-UYTYNIKBSA-N

物化性质

• 溶解度：
  可溶于丙酮、乙醇、乙酸乙酯、甲醇、

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  30
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  166
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  2'-bromoethyl-2,3,4,6-tetra-O-acetyl-α-D-glucopyranoside 在 silver tetrafluoroborate 、 caesium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2’-(乙酰基硫代)乙基2,3,4,6-四-O-乙酰基-beta-D-吡喃葡萄糖苷
  参考文献：
  名称：

  2-（三甲基甲硅烷基）乙基硫化物转化为硫酯

  摘要：

  用羧酸氯化物和AgBF 4在CH 2 Cl 2中处理2-（三甲基甲硅烷基）乙基硫化物可提供高收率和纯度的相应硫酯。将2-（三甲基甲硅烷基）乙基硫化物转化为合成上通用的硫酯，使得这些硫化物可用作巯基保护基，因为这种硫化物易于制备并且对有机合成中遇到的许多反应条件稳定。

  DOI：

  10.1016/s0040-4039(99)00016-7

文献信息

• NOVEL SUGAR-LINKED CHLORIN DERIVATIVE AND PROCESS FOR PRODUCTION THEREOF
  申请人：Rei Medical Co., Ltd.

  公开号：EP2123664A1

  公开（公告）日：2009-11-25

  Disclosed is a novel glycoconjugated chlorin derivative which is useful as a substance for photodynamic therapy, is stable, and can act a photosensitizer having high phototoxicity even when used in a small quantity. Also disclosed is a method of producing the derivative. Specifically disclosed are a S-glycosylated chlorin derivative represented by the following general formula (1) and a metal complex thereof. In the general formula (1), X1 to X20 independently represent a group selected from the group consisting of F-, sugar-S-, sugar-Z-Sand sugar-O-Z-S- and at least one among X1 to X20 represents a group selected from the group consisting of sugar-S-, sugar-Z-S- and sugar-O-Z-S- (wherein F represents a fluorine atom, Z represents an oxygen atom, Z represents a hydrocarbon group having 1 to 6 carbon atoms); and R5 and R6 independently represent a hydrogen atom or an organic group or may together form a ring.

  揭示了一种新颖的糖结合叶绿素衍生物，可用作光动力疗法的物质，具有稳定性，并且即使在少量使用时也能作为具有高光毒性的光敏剂。还公开了一种生产该衍生物的方法。具体公开了以下一般公式（1）表示的S-糖基化叶绿素衍生物及其金属配合物。在一般公式（1）中，X1至X20独立地表示选择自F-、糖-S-、糖-Z-S和糖-O-Z-S的群组，并且X1至X20中至少有一个表示选择自糖-S-、糖-Z-S-和糖-O-Z-S-的群组（其中F表示氟原子，Z表示氧原子，Z表示具有1至6个碳原子的碳氢基团）；R5和R6独立地表示氢原子或有机基团，或者可以共同形成一个环。
• NOVEL GLYCOCONJUGATED CHLORIN DERIVATIVES AND METHOD OF PRODUCING THE SAME
  申请人：Obata Makoto

  公开号：US20090318370A1

  公开（公告）日：2009-12-24

  Disclosed is a novel glycoconjugated chlorin derivative which is useful as a substance for photodynamic therapy, is stable, and can act a photosensitizer having high phototoxicity even when used in a small quantity. Also disclosed is a method of producing the derivative. Specifically disclosed are a S-glycosylated chlorin derivative represented by the following general formula (1) and a metal complex thereof. In the general formula (1), X 1 to X 20 independently represent a group selected from the group consisting of F—, sugar-S—, sugar-Z-S— and sugar-O-Z-S— and at least one among X 1 to X 20 represents a group selected from the group consisting of sugar-S—, sugar-Z-S— and sugar-O-Z-S— (wherein F represents a fluorine atom, Z represents an oxygen atom, Z represents a hydrocarbon group having 1 to 6 carbon atoms); and R 5 and R 6 independently represent a hydrogen atom or an organic group or may together form a ring.