3-(2,6,6-timethylcyclohex-1-enyl)propenoic acid | 4951-39-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(2,6,6-timethylcyclohex-1-enyl)propenoic acid
• 英文别名: 3-(2,6,6-trimethyl-1-cyclohexenyl)acrylic acid；3-<1,3,3,-Trimethyl-cyclohexen-(1)-yl-(2)>-acrylsaeure；3-<2,2,6-Trimethyl-cyclohexen-(6)-yl>-acrylsaeure；3-(1,3,3,-Trimethyl-cyclohexen-(1)-yl-(2))-acrylsaeure；3-(2,6,6-Trimethylcyclohexen-1-yl)prop-2-enoic acid
• CAS: 4951-39-7
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: RCVGWZAQWMJQHG-UHFFFAOYSA-N

物化性质

• 熔点：
  106-108 °C
• 沸点：
  321.9±11.0 °C(Predicted)
• 密度：
  1.052±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(2,6,6-timethylcyclohex-1-enyl)propenoic acid 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以97.5%的产率得到(2E)-3-(2,6,6-三甲基-1-环己烯-1-基)-2-丙烯-1-醇
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS
  [FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT DE TROUBLES OCULAIRES

  摘要：

  公开号：

  WO2016085939A3
• 作为产物：
  描述：

  3-甲基-5-(2,6,6-三甲基-1-环己烯-1-基)-2,4-戊二烯醛 在 重铬酸吡啶 、 溴 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 10.0h， 生成 3-(2,6,6-timethylcyclohex-1-enyl)propenoic acid
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS
  [FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT DE TROUBLES OCULAIRES

  摘要：

  公开号：

  WO2016085939A3

文献信息

• [EN] OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE<br/>[FR] LIGANDS DE LIAISON À L'OPSINE, COMPOSITIONS ET PROCÉDÉS D'UTILISATION
  申请人：BIKAM PHARMACEUTICALS INC

  公开号：WO2010147653A1

  公开（公告）日：2010-12-23

  Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.

  本文披露了用于治疗与视蛋白蛋白质错位、突变视蛋白蛋白质的错误折叠以及在眼睛中积累的有毒视觉循环产物有关的眼科疾病的化合物及该化合物的组合物，以及使用该化合物的方法。还描述了在这些方法中有用的化合物和组合物，无论是单独使用还是与其他治疗剂联合使用。
• NOVEL HYDROXYL PYRANONE COMPOUND, METHOD FOR PRODUCING SAME, AND COSMETICS COMPOSITION COMPRISING COMPOUND
  申请人：AMOREPACIFIC CORPORATION

  公开号：US20180370939A1

  公开（公告）日：2018-12-27

  The present invention relates to a novel hydroxyl pyranone compound, a method for producing same, and a cosmetic composition having the compound. The hydroxyl pyranone compound according to the present invention exhibits markedly improved effectiveness compared to the conventional adipocyte differentiation-promoting material, and thus is preferably included as an active ingredient in a cosmetic composition for increasing skin volume or elasticity.

  本发明涉及一种新型的羟基吡喃酮化合物、其制备方法以及含有该化合物的化妆品组合物。本发明的羟基吡喃酮化合物与传统的脂肪细胞分化促进物相比具有显著的改善效果，因此最好将其作为活性成分包含在用于增加皮肤体积或弹性的化妆品组合物中。
• 아이오논(ionone) 유도체 화합물
  申请人：AMOREPACIFIC CORPORATION (주)아모레퍼시픽(120060241378) Corp. No ▼ 110111-3471036BRN ▼106-86-43373

  公开号：KR20150062443A

  公开（公告）日：2015-06-08

  본 발명은 일측면에서 아이오논 유도체 화합물, 이의 이성질체, 이의 약학적으로 허용 가능한 염, 이의 프로드럭, 이의 수화물 또는 이의 용매화물에 관한 것이다. 본 발명은 다른 일측면에서 아이오논 유도체 화합물, 이의 이성질체, 이의 약학적으로 허용 가능한 염, 이의 프로드럭, 이의 수화물 또는 이의 용매화물을 포함하는 피부노화 방지용 조성물에 관한 것이다.

  本发明涉及一方面的异酮诱导体化合物及其异构体、其药学上允许的盐、其前药、其水合物或其溶剂化合物。本发明另一方面涉及用于皮肤防晒的组合物，其中包括异酮诱导体化合物及其异构体、其药学上允许的盐、其前药、其水合物或其溶剂化合物。
• OFF-NOTE BLOCKING SENSORY ORGANIC COMPOUNDS
  申请人：Ungureanu Ioana Maria

  公开号：US20100284944A1

  公开（公告）日：2010-11-11

  Disclosed are Compounds that block off-notes in consumables and methods of blocking off-notes in consumables including off-notes provided by artificial sweeteners including aspartame, Saccharin, acesulfame K (Acesulfame potassium), sucralose and cyclamate; and including stevioside, swingle extract, glyccerhizin, perillartine, naringin dihydrochalcone, neohesperidine dihydrochalcone, mogroside V, rubusoside, rubus extract, and rebaudioside A.

  本发明涉及用于阻断食品中的异味的化合物以及阻断食品中异味的方法，其中包括人造甜味剂如阿斯巴甜、糖精、K糖果素、三氯蔗糖和环糊精所提供的异味；包括甜菊糖苷、秦皮提取物、甘草苷、紫苏烯、柚皮苷双糖苷、柚皮苷双糖苷、罗汉果甙V、悬钩子苷、悬钩子提取物和甜菜碱A。
• Opsin-binding ligands, compositions and methods of use
  申请人：Garvey David S.

  公开号：US20110003784A1

  公开（公告）日：2011-01-06

  Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.

  本文披露了用于治疗与视蛋白蛋白质错位、突变视蛋白蛋白质的错折和在眼中积累有毒视觉循环产物相关的眼科疾病的化合物和该化合物的组合物以及使用该化合物的方法。本文还描述了用于这些方法的化合物和组合物，可以单独使用或与其他治疗药物联合使用。