3'-氨基-3'-脱氧腺苷 | 2504-55-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 中文名称: 3'-氨基-3'-脱氧腺苷
• 英文名称: 3'-Amino-3'-deoxyadenosin
• 英文别名: 3'-amino-3'-deoxy-adenosine；4-Amino-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol
• CAS: 2504-55-4；26315-51-5；32077-67-1；51014-76-7
• 化学式: C₁₀H₁₄N₆O₃
• 分子量: 266.26
• InChiKey: ILDPUOKUEKVHIL-UHFFFAOYSA-N

物化性质

• 熔点：
  260-261 °C
• 沸点：
  409.46°C (rough estimate)
• 密度：
  1.2946 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  145
• 氢给体数：
  4
• 氢受体数：
  8

安全信息

• 储存条件：
  库房应保持通风、低温和干燥的环境。

制备方法与用途

类别：有毒物品

毒性分级：剧毒

急性毒性：腹腔-小鼠LD50: 28 毫克/公斤

可燃性危险特性：可燃；燃烧时产生有毒氮氧化物烟雾

储运特性：库房需通风、低温且干燥

灭火剂：干粉、泡沫、砂土、二氧化碳，或使用雾状水

文献信息

• 3'',5''-DIMETHOXYBENZOYL-3'-AMINO-3'-DEOXYADENOSINE-5'-TRIPHOSPHATES AND PHARMACEUTICAL USES THEREOF
  申请人：Danmir Therapeutics, LLC

  公开号：US20210054015A1

  公开（公告）日：2021-02-25

  Provided are compounds compound according to Formula (I), or a pharmaceutically acceptable salt, solvate, coordination complex or prodrug thereof: wherein, R 1 and R 2 are independently selected from (C 1 -C 6 ) alkyl. The compounds have P2X3 receptor or P2X2/3 receptor antagonist activity and are useful for the treatment of diseases and disorders characterized by activation of those receptors.
• ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK
  申请人：NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING

  公开号：US20210338706A1

  公开（公告）日：2021-11-04

  The present invention provides a kind of nucleoside analogue compounds, and a composition comprising the compound and pentostatin, their use for modulating circadian rhythm, preferably, for shifting circadian phase, and methods for modulating circadian rhythm, preferably, for shifting circadian phase via the compound or the composition.
• US7348315B2
  申请人：——

  公开号：US7348315B2

  公开（公告）日：2008-03-25