3,3-二甲基-1-[(2-甲基-2-丙基)氧基]丁烷 | 4419-58-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3,3-二甲基-1-[(2-甲基-2-丙基)氧基]丁烷
• 英文名称: tert-butyl 3,3-dimethylbutyl ether
• 英文别名: tert.-Butyl-<3,3-dimethyl-butyl>-aether；1-tert-butoxy-3,3-dimethyl-butane；Ether, tert-butyl 3,3-dimethylbutyl；3,3-dimethyl-1-[(2-methylpropan-2-yl)oxy]butane
• CAS: 4419-58-3
• 化学式: C₁₀H₂₂O
• 分子量: 158.284
• InChiKey: DGZYZEOJFVHACS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909199090

反应信息

• 作为产物：
  描述：

  过氧化苯甲酸叔丁酯 、 3,3-二甲基-1-氯丁烷 在 magnesium 作用下， 以 乙醚 为溶剂， 生成 3,3-二甲基-1-[(2-甲基-2-丙基)氧基]丁烷
  参考文献：
  名称：

  Mass Spectrometry in Structural and Stereochemical Problems. LXXV.¹ Occurrence of Alkyl Rearrangements in the Fragmentation of Some Formaldehyde Acetals²

  摘要：

  DOI：

  10.1021/ja00948a028

文献信息

• Substituted Heteroaromatic Pyrazole-Containing Carboxamide and Urea Compounds as Vanilloid Receptor Ligands
  申请人：FRANK Robert

  公开号：US20130029962A1

  公开（公告）日：2013-01-31

  Substituted heteroaromatic pyrazole-containing carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also to a method of using these compounds for treating and/or inhibiting pain and further diseases and/or disorders.

  含有杂环吡唑基的羧酰胺和脲化合物作为辣椒素受体配体，含有这些化合物的药物组合物，以及使用这些化合物治疗和/或抑制疼痛以及进一步疾病和/或疾病的方法。
• Methylphenidate-Prodrugs, Processes of Making and Using the Same
  申请人：KemPharm, Inc.

  公开号：US20150266911A1

  公开（公告）日：2015-09-24

  The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

  目前的技术是针对前药和组合物的，用于治疗包括甲基苯丙胺或甲基苯丙胺衍生物的至少与醇、胺、羧酸、硫醇或其衍生物结合的各种疾病和/或紊乱。在某些实施例中，这些结合物还包括至少一个连接剂。该技术还涉及合成甲基苯丙胺或甲基苯丙胺衍生物，结合至少一个醇、胺、羧酸、硫醇或其衍生物或其组合的方法。
• CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME
  申请人：Arvinas, Inc.

  公开号：US20180215731A1

  公开（公告）日：2018-08-02

  The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

  该描述涉及cereblon E3连接酶结合化合物，包括包含相同成分的双功能化合物，这些化合物作为靶向泛素化的调节剂具有实用价值，尤其是抑制剂，可降解和/或以其他方式抑制根据本公开的双功能化合物。特别是，该描述提供了化合物，其一端含有与cereblon E3泛素连接酶结合的配体，另一端含有与目标蛋白结合的部分，使目标蛋白位于泛素连接酶附近以降解（和抑制）该蛋白。可以合成表现出广泛药理活性的化合物，与几乎所有类型的靶向多肽的降解/抑制一致。
• SUBSTITUTED 4-AMINOBENZAMIDES AS KCNQ2/3 MODULATORS
  申请人：GRUENENTHAL GMBH

  公开号：US20130281452A1

  公开（公告）日：2013-10-24

  Substituted 4-aminobenzamides, pharmaceutical compositions containing these compounds and also methods of using these compounds in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

  取代的4-氨基苯甲酰胺，包含这些化合物的药物组合物以及使用这些化合物治疗和/或预防疼痛以及进一步疾病和/或失调的方法。
• SPECIFIC CARBOXAMIDES AS KCNQ2/3 MODULATORS
  申请人：GRÜNENTHAL GMBH

  公开号：US20140148468A1

  公开（公告）日：2014-05-29

  The invention relates to specific carboxamides, to processes for their preparation, to medicaments comprising these compounds and to the use of these compounds in the preparation of medicaments.

  这项发明涉及特定的羧酰胺，涉及它们的制备过程，包括这些化合物的药物以及这些化合物在药物制备中的应用。