3,3-二苯基-3H-吲哚 | 40863-36-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 3,3-二苯基-3H-吲哚
• 英文名称: 3,3-diphenyl-3H-indole
• 英文别名: 3,3-Diphenylindole
• CAS: 40863-36-3
• 化学式: C₂₀H₁₅N
• 分子量: 269.346
• InChiKey: WFHWKNMXPKMUTE-UHFFFAOYSA-N

物化性质

• 熔点：
  90-93 °C(Solv: hexane (110-54-3); benzene (71-43-2))
• 沸点：
  415.2±45.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,3-二苯基-3H-吲哚 在 sodium cyanoborohydride 作用下， 生成 3,3-Diphenylindoline
  参考文献：
  名称：

  Barton, Derek H. R.; Blazejewski, Jean-Claude; Charpiot, Brigitte, Journal of the Chemical Society. Perkin transactions I, 1985, p. 2667 - 2676

  摘要：

  DOI：
• 作为产物：
  描述：

  联苯乙醛 、 苯肼 在 溶剂黄146 作用下， 反应 0.5h， 生成 3,3-二苯基-3H-吲哚
  参考文献：
  名称：

  Rearrangement of 3,3-Disubstituted Indolenines and Synthesis of 2,3-Substituted Indoles

  摘要：

  Synthesis of 2,3-substituted indoles from phenylhydrazine and alpha-branched aldehydes via rearrangement of 3,3-disubstituted indolenine intermediates is reported.

  DOI：

  10.1021/ol0623567

文献信息

• Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation
  申请人：Children's Medical Center Corporation

  公开号：US20020198188A1

  公开（公告）日：2002-12-26

  The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

  本发明提供了取代的3,3-二苯基茚酮，茚烷和吲哚化合物及其类似物，它们是哺乳动物细胞增殖的特异性，有效和安全的抑制剂。这些化合物可用于抑制哺乳动物细胞在体内的增殖，作为治疗或预防由于细胞异常增殖而表现为疾病的方法，例如癌症。
• Methods for the treatment or prevention of inflammatory diseases characterized by abnormal cell proliferation
  申请人：——

  公开号：US20020128256A1

  公开（公告）日：2002-09-12

  The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof which are specific, potent and safe inhibitors of the Ca 2+ -activated potassium channel (Gardos channel) of erythrocytes. The compounds can be used as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation.

  本发明提供了取代的3,3-二苯基茚酮、茚烷和吲哚化合物，以及特异性、有效和安全的类似物，它们是红细胞的Ca2+-活化钾通道（Gardos通道）的抑制剂。这些化合物可以作为治疗镰状细胞病和以不需要或异常细胞增殖为特征的疾病的有效药物，特别是与不需要的细胞增殖相关的炎症性疾病。
• Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation
  申请人：Children's Medical Center Corporation

  公开号：US20040242563A1

  公开（公告）日：2004-12-02

  The present invention provides substituted 3,3-phenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

  本发明提供了取代的 3,3-苯基茚酮、茚满和吲哚化合物及其类似物，它们是哺乳动物细胞增殖的特异、强效和安全的抑制剂。这些化合物可用于原位抑制哺乳动物细胞增殖，作为治疗或预防以细胞异常增殖为特征的疾病（如癌症）的一种治疗方法。
• BARTON, D. H. R.;BLAZEJEWSKI, J. -C.;CHARPIOT, B.;FINET, J. -P.;MOTHERWEL+, J. CHEM. SOC. PERKIN TRANS., 1985, N 12, 2667-2675
  作者：BARTON, D. H. R.、BLAZEJEWSKI, J. -C.、CHARPIOT, B.、FINET, J. -P.、MOTHERWEL+

  DOI：——

  日期：——
• USE OF SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS FOR THE TREATMENT OR PREVENTION OF SICKLE CELL DISEASE, INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELLPROLIFERATION, DIARRHE AND SCOURS
  申请人：CHILDREN'S MEDICAL CENTER CORPORATION

  公开号：EP1032385A1

  公开（公告）日：2000-09-06