1-(3,4-Dihydroxy-2-methylphenyl)ethanone | 66296-84-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3,4-Dihydroxy-2-methylphenyl)ethanone
• CAS: 66296-84-2
• 化学式: C₉H₁₀O₃
• 分子量: 166.177
• InChiKey: UIMZFUBGXASMQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,3-二羟基丙酮 以 水 为溶剂， 生成 1-(3,4-Dihydroxy-2-methylphenyl)ethanone
  参考文献：
  名称：

  Popoff,T. et al., Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1978, vol. 32, p. 1 - 7

  摘要：

  DOI：

文献信息

• NOVEL MODULATORS OF PROTEIN KINASE SIGNALING
  申请人：Reuveni Hadas

  公开号：US20110105618A1

  公开（公告）日：2011-05-05

  The present invention provides new tyrphostin derivatives acting as protein kinase (PK) and receptor kinase (RK) signaling modulators. The invention further provides methods of their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for preventions and treatments of PK and RK related disorders such as metabolic, inflammatory, fibrotic, and cell proliferative disorders, in particular cancer.

  本发明提供了新的酪氨酸激酶（PK）和受体激酶（RK）信号调节剂的酪氨酸激酶抑制剂衍生物。本发明还提供了其制备方法，包括这些化合物的制药组合物，以及使用这些化合物和组合物的方法，特别是作为化疗药物，用于预防和治疗PK和RK相关疾病，如代谢性、炎症性、纤维化和细胞增生性疾病，特别是癌症。
• CEPHEM COMPOUND HAVING CATECHOL GROUP
  申请人：Hisakawa Shinya

  公开号：US20130102583A1

  公开（公告）日：2013-04-25

  A compound of the formula: wherein X is —N═, —CH═, or the like; W is —CH 2 — or the like; U is —S— or the like; R 1 and R 2 are each independently hydrogen, halogen, optionally substituted lower alkyl, or the like; R 3 is hydrogen or the like; each R 4 is independently hydrogen, halogen, or the like; m is an integer from 0 to 2; Q is a single bond, or the like; G is —C(═O)—, or the like; D is a single bond, —NH—, or the like; and E is a cyclic quaternary ammonium group, or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.
• US9145425B2
  申请人：——

  公开号：US9145425B2

  公开（公告）日：2015-09-29
• Popoff,T. et al., Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1978, vol. 32, p. 1 - 7
  作者：Popoff,T. et al.

  DOI：——

  日期：——