mannitol-1,6-bis-phosphate | 13400-43-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: mannitol-1,6-bis-phosphate
• 英文别名: mannitol bis-phosphate；O¹,O⁶-diphosphono-D-mannitol；O¹,O⁶-Diphosphono-D-mannit；1,6-Bis-phosphonooxy-D-manno-hexan-2,3,4,5-tetraol；D-Mannitol-1,6-diphosphate；[(2R,3R,4R,5R)-2,3,4,5-tetrahydroxy-6-phosphonooxyhexyl] dihydrogen phosphate
• CAS: 13400-43-6
• 化学式: C₆H₁₆O₁₂P₂
• 分子量: 342.133
• InChiKey: WOYYTQHMNDWRCW-KVTDHHQDSA-N

物化性质

• 沸点：
  801.4±75.0 °C(Predicted)
• 密度：
  2.010±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.8
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  214
• 氢给体数：
  8
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  (2R,3R,4R,5R)-2,3,4,5-tetrakis(benzyloxy)hexane-1,6-diyl bis(dihydrogen phosphate) 在 palladium on activated charcoal 氢气 作用下， 20.0 ℃ 、100.0 kPa 条件下， 生成 mannitol-1,6-bis-phosphate
  参考文献：
  名称：

  Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases

  摘要：

  We report the first unambiguous syntheses of glucitol-1,6-bis-phosphate and mannitol-1,6-bis-phosphate and their competitive inhibition of various fructose bis-phosphate aldolases. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.01.076

文献信息

• Ukita; Nagasawa, Chemical and pharmaceutical bulletin, 1959, vol. 7, p. 401,406
  作者：Ukita、Nagasawa

  DOI：——

  日期：——
• [EN] ACTIVATION OF RAS BY A FRUCTOSE-1,6-BISPHOSPHATE / GUANINE NUCLEOTIDE EXCHANGE PROTEIN COMPLEX<br/>[FR] ACTIVATION DE RAS PAR UN COMPLEXE DE PROTÉINE D'ÉCHANGE NUCLÉOTIDIQUE FRUCTOSE-1,6-BISPHOSPHATE / GUANINE
  申请人：VIB VZW

  公开号：WO2015011222A1

  公开（公告）日：2015-01-29

  The present invention relates to an isolated fructose-1,6-bisphosphate / SOS complex. The invention relates further to the use of the complex to screen for compounds that modulate the activation of Ras, and the use of yeast strains for said screening. The invention relates also to compounds, disrupting the fructose-1,6-bisphosphate / SOS complex and the use of such compounds in the treatment of cancer.
• Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases
  作者：Charles-Gabin Mabiala-Bassiloua、Magdalena Zwolinska、Helene Therisod、Jurgen Sygusch、Michel Therisod

  DOI：10.1016/j.bmcl.2008.01.076

  日期：2008.3

  We report the first unambiguous syntheses of glucitol-1,6-bis-phosphate and mannitol-1,6-bis-phosphate and their competitive inhibition of various fructose bis-phosphate aldolases. (C) 2008 Elsevier Ltd. All rights reserved.