3,4-二甲氧基苯-1,2-二胺 | 67394-73-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,4-二甲氧基苯-1,2-二胺
• 英文名称: 1,2-diamino-5,6-dimethoxybenzene
• 英文别名: 3,4-dimethoxy-o-phenylenediamine；3,4-Dimethoxy-o-phenylendiamin；3.4-Diamino-brenzcatechin-dimethylaether；3.4-Diamino-veratrol；1,2-Diamino-5,6-dimethoxy-benzol；3,6-Dimethoxy-o-phenylendiamin；3,4-Dimethoxybenzene-1,2-diamine
• CAS: 67394-73-4
• 化学式: C₈H₁₂N₂O₂
• 分子量: 168.195
• InChiKey: QHKDQJHPIRRPBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  70.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,4-二甲氧基苯-1,2-二胺 在 盐酸 、 potassium carbonate 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-4,5-dimethoxy-1H-benzimidazole
  参考文献：
  名称：

  Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474)

  摘要：

  A structure activity relationship (SAR) study of the pan class I PI 3-kinase inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474) identified substitution at the 4 and 6 positions of the benzimidazole ring as having significant effects on the potency of substituted derivatives. The 6-amino-4-methoxy analogue displayed a greater than 1000-fold potency enhancement over the corresponding 6-aza-4-methoxy analogue against all three class Ia PI 3-kinase enzymes (p110 alpha, p110 beta, and p110 delta) and also displayed significant potency against two mutant forms of the p110 alpha isoform (H1047R and E545K). This compound was also evaluated in vivo against a U87MG human glioblastoma tumor xenograft model in Ragl(-/-) mice, and at a dose of 50 mg/kg given by ip injection at a qd x 10 dosing schedule it dramatically reduced cancer growth by 81% compared to untreated controls.

  DOI：

  10.1021/jm200688y
• 作为产物：
  描述：

  3,4-dimethoxy-2-nitrobenzoic acid chloride 在 二硫化碳 、 sodium hypobromide 、 氨 、 铁粉 、 溶剂黄146 作用下， 生成 3,4-二甲氧基苯-1,2-二胺
  参考文献：
  名称：

  Pisovschi, Chemische Berichte, 1910, vol. 43, p. 2140

  摘要：

  DOI：

文献信息

• POLYMER-CARBOHYDRATE CONJUGATES FOR DRUG DELIVERY TECHNOLOGY
  申请人：Wu Nian

  公开号：US20150157721A1

  公开（公告）日：2015-06-11

  The invention comprises compounds, methods of making, and methods of using. The compounds may have a linear or cylic backbone and three or four appended functional groups: one or two lipohilic compounds including sterols or “fat soluble” vitamins, one or two hydrophilic polymer, and one or two carbohydrate. A group of polymer-carbohydrate conjugates having a central backbone and three appended functional groups are disclosed wherein one lipophilic compound is void of both steroid acids. The conjugate may have fatty acids as the primary lipophilic carrier, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.

  该发明包括化合物、制备方法和使用方法。这些化合物可能具有线性或环状的骨架，以及三个或四个附加的功能基团：一个或两个疏水化合物，包括固醇或“脂溶性”维生素，一个或两个亲水性聚合物，以及一个或两个碳水化合物。公开了一组具有中心骨架和三个附加功能基团的聚合物-碳水化合物共轭物，其中一个疏水性化合物不含类固醇酸。该共轭物可能以脂肪酸作为主要疏水载体，一个亲水性聚合物和一个碳水化合物。特定的功能基团可以根据在制备药物、化妆品、营养保健品等方面的具体应用而选择。共轭物的典型偶联反应可能涉及一种或多种或组合或串联的烷基化，包括N-烷基化或O-烷基化，醚化，酯化和酰胺化化学过程。还可以选择各种连接剂连接骨架和功能基团之间，以修改载体或中心骨架以进行偶联反应并优化共轭物的性能。
• [EN] POLYMER-CYCLODEXTRIN-LIPID CONJUGATES<br/>[FR] CONJUGUÉS POLYMÈRE-CYCLODEXTRINE-LIPIDE
  申请人：WU NIAN

  公开号：WO2016209732A1

  公开（公告）日：2016-12-29

  The invention comprises compounds, methods of making, and methods of using. A group of polymer-cyclodextrin-lipid conjugates having a center backbone and three or four appended functional groups are disclosed, wherein one of the hydrophilic components is cyclodextrin. The compounds may have a backbone with three or four appended functional groups: one or two lipophilic compounds including sterols or "fat soluble" vitamins or fatty acids, one or two hydrophilic polymer and one cyclodextrin. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the center backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.

  该发明涵盖了化合物、制备方法和使用方法。公开了一组具有中心骨架和三个或四个附加功能基团的聚合物-环糊精-脂质共轭物，其中一个亲水成分是环糊精。这些化合物可能具有一个带有三个或四个附加功能基团的骨架：一个或两个疏水化合物，包括甾醇或“脂溶性”维生素或脂肪酸，一个或两个亲水性聚合物和一个环糊精。特定的功能基团可以针对制备药物、化妆品、营养保健品等特定应用进行选择。共轭物的典型偶联反应可能涉及一种或多种或组合或串联的烷基化，包括N-烷基化或O-烷基化，醚化，酯化和酰胺化化学过程。还可以选择各种连接剂连接中心骨架和功能基团，以修改载体或中心骨架用于偶联反应并优化共轭物的性能。
• Dye photosensitized cationic ring-opening polymerization: Search for new dye skeletons
  作者：Jacques Lalevée、Frédéric Dumur、Mohamad-Ali Tehfe、Abbas Zein-Fakih、Didier Gigmes、Fabrice Morlet-Savary、Bernadette Graff、Jean-Pierre Fouassier

  DOI：10.1016/j.polymer.2012.08.067

  日期：2012.10

  New dyes (based on diamine, oligophenylenevinylene, salphen ligands and polyazine skeletons) are checked here for the formation of free radicals under very soft irradiation conditions (halogen lamp, blue or green LED bulbs and laser diode at 457 nm) under air. Three component systems involving a combination of diamine (or oligophenylenevinylene) dye/diphenyl iodonium salt/silane (or N-vinylcarbazole

  此处检查了新染料（基于二胺，低聚亚苯基亚乙烯基，二烯配体和聚嗪骨架）在空气中非常柔和的辐照条件下（卤素灯，蓝色或绿色LED灯泡和457 nm的激光二极管）形成的自由基。使用涉及二胺（或低聚亚苯基亚乙烯基）染料/二苯基碘鎓盐/硅烷（或N-乙烯基咔唑NVK）的组合的三组分体系。获得了出色的开环聚合ROP曲线。还提供了这些染料与曙红-Y（用作众所周知的参考染料）的能力的比较。通过ESR和发光实验详细研究了化学机理。在可见光下，这些体系会生成芳基，甲硅烷基或αN自由基，这些自由基很容易被氧化，从而促进环氧单体的开环聚合。R 3 Si +）或N-乙烯基咔唑衍生的阳离子（NVK +）是聚合引发结构。
• Chemical compounds
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0246774A1

  公开（公告）日：1987-11-25

  Compounds of structure (I) in which, R1 to R4 are the same or different and are each hydrogen, halogen, trifluoromethyl, C1-6alkyl, C1-6alkoxy, C1-6alkanoyl, C1-6alkoxycarbonyl, RCF20, an ethoxy group substituted by 3 to 5 fluorine atoms, or R2 and R3 together form a group -O(CR2)mO-; R is hydrogen or fluorine; m is 1 or 2; n is 0 or 1; R5 and R6 are the same or different and are each hydrogen, C1-6alkyl or C3-6cycloalkyl or R5 and R6 together with the nitrogen atom to which they are attached form an azetidino, pyrrolidino, piperidino, piperazino, N-C1- 4alkylpiperazino or morpholino group; and one of R7 and R8 is fluorine, and the other is hydrogen, fluorine or C1-6alkyl; processes and intermediates for their preparation, formulations containing them and their use in therapy for the inhibition of exogenously and endogenously stimulated gastric acid secretion.

  结构(I)的化合物 其中，R1 至 R4 相同或不同，各自为氢、卤素、三氟甲基、C1-6烷基、C1-6烷氧基、C1-6烷酰基、C1-6烷氧羰基、RCF20、被 3 至 5 个氟原子取代的乙氧基，或 R2 和 R3 共同形成一个基团-O(CR2)mO-；R 为氢或氟；m 为 1 或 2；n 为 0 或 1；R5 和 R6 相同或不同，各自为氢、C1-6 烷基或 C3-6 环烷基，或 R5 和 R6 与它们所连接的氮原子一起形成叠氮基、吡咯烷基、哌啶基、哌嗪基、N-C1- 4 烷基哌嗪基或吗啉基；R7和R8中的一个是氟，另一个是氢、氟或C1-6烷基；制备它们的工艺和中间体、含有它们的制剂以及它们在治疗中用于抑制外源性和内源性刺激的胃酸分泌。
• Polymer-cyclodextrin-lipid conjugates
  申请人：Wu Nian

  公开号：US10064954B2

  公开（公告）日：2018-09-04

  The invention comprises compounds, methods of making, and methods of using. A group of polymer-cyclodextrin-lipid conjugates having a center backbone and three or four appended functional groups are disclosed, wherein one of the hydrophilic components is cyclodextrin. The compounds may have a backbone with three or four appended functional groups: one or two lipophilic compounds including sterols or “fat soluble” vitamins or fatty acids, one or two hydrophilic polymer and one cyclodextrin. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutraceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the center backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.

  本发明包括化合物、制造方法和使用方法。本发明公开了一组聚合物-环糊精-脂质共轭物，它们具有一个中心骨架和三个或四个附加官能团，其中一个亲水组分是环糊精。这些化合物的骨架可具有三个或四个附加官能团：一个或两个亲脂化合物（包括固醇或 "脂溶性 "维生素或脂肪酸）、一个或两个亲水性聚合物和一个环糊精。可根据配制药品、化妆品、营养保健品等的具体应用选择特定的官能团。共轭物的典型偶联反应可能涉及一种或多种烷基化反应，也可能是烷基化反应的组合或串联，包括 N-烷基化反应或 O-烷基化反应、醚化反应、酯化反应和酰胺化反应等化学过程。中心骨架和官能团之间还可以选择各种连接物，以修饰用于偶联反应的载体或中心骨架，优化共轭物的性能。