tert-butyl-[2-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enyl]-3,5-dimethoxyphenoxy]-dimethylsilane | 492450-86-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: tert-butyl-[2-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enyl]-3,5-dimethoxyphenoxy]-dimethylsilane
• CAS: 492450-86-9
• 化学式: C₂₅H₃₆O₅Si
• 分子量: 444.643
• InChiKey: ZAYIWKWFZIANIB-ZHACJKMWSA-N

物化性质

• 沸点：
  513.5±50.0 °C(Predicted)
• 密度：
  1.035±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.36
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl-[2-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enyl]-3,5-dimethoxyphenoxy]-dimethylsilane 在 盐酸 、 AD-mix-β 作用下， 以 甲醇 为溶剂， 生成 (3S)-2-(3,4-dimethoxyphenyl)-5,7-dimethoxychroman-3-ol
  参考文献：
  名称：

  Ruthenium-Catalyzed Olefin Cross Metathesis of Styrenes as an Alternative to the Heck and Cross-Coupling Reactions

  摘要：

  The use of olefin cross metathesis as a method for the formation of styrenyl-olefins is described using allylic substituted olefins and electron-deficient olefins. These methods provide an orthogonal method to alternative olefination strategies, such as the Heck reaction. These methods have also been employed in the total synthesis of 3-flavanols.

  DOI：

  10.1002/1615-4169(200208)344:6/7<634::aid-adsc634>3.0.co;2-k
• 作为产物：
  描述：

  3,4-二甲氧基苯乙烯 、 3-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-1-propene 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以82%的产率得到tert-butyl-[2-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enyl]-3,5-dimethoxyphenoxy]-dimethylsilane
  参考文献：
  名称：

  Ruthenium-Catalyzed Olefin Cross Metathesis of Styrenes as an Alternative to the Heck and Cross-Coupling Reactions

  摘要：

  The use of olefin cross metathesis as a method for the formation of styrenyl-olefins is described using allylic substituted olefins and electron-deficient olefins. These methods provide an orthogonal method to alternative olefination strategies, such as the Heck reaction. These methods have also been employed in the total synthesis of 3-flavanols.

  DOI：

  10.1002/1615-4169(200208)344:6/7<634::aid-adsc634>3.0.co;2-k

文献信息

• Ruthenium-Catalyzed Olefin Cross Metathesis of Styrenes as an Alternative to the Heck and Cross-Coupling Reactions
  作者：Arnab K. Chatterjee、F. Dean Toste、Tae-Lim Choi、Robert H. Grubbs

  DOI：10.1002/1615-4169(200208)344:6/7<634::aid-adsc634>3.0.co;2-k

  日期：2002.8

  The use of olefin cross metathesis as a method for the formation of styrenyl-olefins is described using allylic substituted olefins and electron-deficient olefins. These methods provide an orthogonal method to alternative olefination strategies, such as the Heck reaction. These methods have also been employed in the total synthesis of 3-flavanols.