ethyl 1-isopropyl-5-(3-methylenecyclobutyl)-1H-pyrazole-3-carboxylate | 1418274-42-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 1-isopropyl-5-(3-methylenecyclobutyl)-1H-pyrazole-3-carboxylate
• 英文别名: Ethyl 1-isopropyl-5-(3-methylenecyclobutyl)-1H-pyrazole-3-carboxylate；ethyl 5-(3-methylidenecyclobutyl)-1-propan-2-ylpyrazole-3-carboxylate
• CAS: 1418274-42-6
• 化学式: C₁₄H₂₀N₂O₂
• 分子量: 248.325
• InChiKey: FKESBIMCAITFPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 1-isopropyl-5-(3-methylenecyclobutyl)-1H-pyrazole-3-carboxylate 在 sodium periodate 、 ruthenium(III) trichloride hydrate 作用下， 以 水 、 乙腈 为溶剂， 反应 0.75h， 以5.8 g的产率得到ethyl 1-isopropyl-5-(3-oxocyclobutyl)-1H-pyrazole-3-carboxylate
  参考文献：
  名称：

  NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING COMPOUNDS

  摘要：

  本发明涉及结合NR1H4受体（FXR）并作为FXR激动剂的化合物。该发明还涉及利用这些化合物制备药物以治疗疾病和/或病况，通过这些化合物结合所述核受体，并涉及这些化合物的合成过程。

  公开号：

  US20140221659A1
• 作为产物：
  描述：

  3-亚甲基环丁基甲腈 在 sodium ethanolate 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 7.75h， 生成 ethyl 1-isopropyl-5-(3-methylenecyclobutyl)-1H-pyrazole-3-carboxylate
  参考文献：
  名称：

  NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING COMPOUNDS

  摘要：

  本发明涉及结合NR1H4受体（FXR）并作为FXR激动剂的化合物。该发明还涉及利用这些化合物制备药物以治疗疾病和/或病况，通过这些化合物结合所述核受体，并涉及这些化合物的合成过程。

  公开号：

  US20140221659A1

文献信息

• Novel FXR (NR1H4) binding and activity modulating compounds
  申请人：Phenex Pharmaceuticals AG

  公开号：EP2545964A1

  公开（公告）日：2013-01-16

  The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds. wherein R is selected from the group consisting of COOR6, CONR7R8, tetrazolyl, SO2NR7R8, C1-6 alkyl, SO2-C1-6 alkyl and H, with R6 independently selected from the group consisting of H or C1-6 alkyl, and R7 and R8 independently from each other selected from the group consisting of H, C1-6 alkyl, halo-C1-6 alkyl, C1-6 alkylene-R9, SO2-C1-6 alkyl, wherein R9 is selected from the group consisting of COOH, OH and SO3H; A is selected from the group consisting of phenyl, pyridyl, pyrimidyl, pyrazolyl, indolyl, thienyl, benzothienyl, indazolyl, benzisoxazolyl, benzofuranyl, benzotriazolyl, furanyl, benzothiazolyl, thiazolyl, oxadiazolyl, each optionally substituted with one or two groups independently selected from the group consisting of OH, O-C1-6 alkyl, O-halo-C1-6 alkyl, C1-6 alkyl, halo-C1-6 alkyl, C3-6 cycloalkyl and halogen; Q is selected from the group consisting of phenyl, pyridyl, thiazolyl, thiophenyl, pyrimidyl, each optionally substituted with one or two groups independently selected from the group consisting of C1-6 alkyl, halo-C1-6 alkyl, halogen and CF3; Y is selected from N or CH; Z is selected from wherein X= CH, N, NO.

  本发明涉及与NR1H4受体（FXR）结合并作为NR1H4受体（FXR）激动剂的化合物。该发明还涉及利用这些化合物制备用于治疗疾病和/或病况的药物，通过这些化合物结合所述核受体来实现，并涉及一种合成这些化合物的方法。其中R从COOR6，CONR7R8，四唑基，SO2NR7R8，C1-6烷基，SO2-C1-6烷基和H组成的群体中选择，R6独立地从H或C1-6烷基组成的群体中选择，R7和R8相互独立地从H，C1-6烷基，卤代C1-6烷基，C1-6烷基烯基-R9，SO2-C1-6烷基中选择，其中R9从COOH，OH和SO3H组成的群体中选择；A从苯基，吡啶基，嘧啶基，吡唑基，吲哚基，噻吩基，苯并噻吩基，吲哚啉基，苯并异噁唑基，苯并呋喃基，苯并三唑基，呋喃基，苯并噻唑基，噻唑基，氧代二唑基中选择，每种基可选择地被一个或两个基独立地从OH，O-C1-6烷基，O-卤代C1-6烷基，C1-6烷基，卤代C1-6烷基，C3-6环烷基和卤素取代；Q从苯基，吡啶基，噻唑基，噻吩基，嘧啶基中选择，每种基可选择地被一个或两个基独立地从C1-6烷基，卤代C1-6烷基，卤素和CF3中选择；Y从N或CH中选择；Z从中选择其中X= CH，N，NO。
• FXR (NR1H4) binding and activity modulating compounds
  申请人：Kinzel Olaf

  公开号：US09139539B2

  公开（公告）日：2015-09-22

  The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

  本发明涉及结合NR1H4受体（FXR）并作为FXR激动剂的化合物。本发明进一步涉及使用这些化合物制备用于通过这些化合物结合所述核受体治疗疾病和/或病况的药物，并涉及制备这些化合物的过程。
• NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING AZOLES
  申请人：Gilead Sciences, Inc.

  公开号：EP3246070A1

  公开（公告）日：2017-11-22

  The present invention relates to compounds which bind to the NR1 H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

  本发明涉及与 NR1 H4 受体（FXR）结合并作为 FXR 激动剂的化合物。本发明还涉及化合物的用途，即通过所述化合物与所述核受体结合制备治疗疾病和/或病症的药物，以及所述化合物的合成工艺。
• NOVEL FXR (NR1H4) MODULATING COMPOUNDS
  申请人：Gilead Sciences, Inc.

  公开号：EP2731676B1

  公开（公告）日：2016-02-03
• US9139539B2
  申请人：——

  公开号：US9139539B2

  公开（公告）日：2015-09-22