8-Methyl-2-naphthoesaeure | 5043-23-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-Methyl-2-naphthoesaeure
• 英文别名: 1-Methylnaphthalene-7-carboxylic acid；8-methylnaphthalene-2-carboxylic acid
• CAS: 5043-23-2
• 化学式: C₁₂H₁₀O₂
• 分子量: 186.21
• InChiKey: WGIPVKFOAZITET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-Methyl-2-naphthoesaeure 在 palladium on activated charcoal 吡啶 、 盐酸 、 4-二甲氨基吡啶 、 N-溴代丁二酰亚胺(NBS) 、 过氧化氢苯甲酰 、 2-硝基丙烷 、 lithium methanolate 、 氢气 、 sodium methylate 、 potassium carbonate 、 三乙胺 、 对甲苯磺酰氯 、 三氟乙酸 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 丙酮 、 正丁醇 、 苯 为溶剂， 反应 23.17h， 生成 (+/-)-erythro-2-(hydroxymethyl)-5-<7-(methoxycarbonyl)naphthalen-1-yl>pentanoic acid 1,3-lactone
  参考文献：
  名称：

  Synthesis and Biological Activity of New 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Synthase Inhibitors: 2-Oxetanones with a Side Chain Mimicking the Folded Structure of 1233A.

  摘要：

  为模拟1233A（1）的折叠侧链构象，该化合物是一种3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）合酶抑制剂，合成了侧链含有芳环的1233A类似物。其中2-恶坦酮部分保持不变。在1233A及其合成类似物中，反式-3-羟甲基-4-[2-(7-甲氧羰基-1-萘基)乙基]-2-恶坦酮（23）显示了最高的HMG-CoA合酶体外抑制活性。讨论了侧链上的构效关系。

  DOI：

  10.1248/cpb.42.512
• 作为产物：
  描述：

  在 sulfur 作用下， 生成 8-Methyl-2-naphthoesaeure
  参考文献：
  名称：

  Adcock,W.; Wells,P.R., Australian Journal of Chemistry, 1965, vol. 18, p. 1351 - 1364

  摘要：

  DOI：

文献信息

• NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE
  申请人：Kinoyama Isao

  公开号：US20120142727A1

  公开（公告）日：2012-06-07

  [Object] An excellent agent for preventing or treating dementia, schizophrenia, and the like, based on serotonin 5-HT 5A receptor modulating action, is provided. [Means for Solution] It was confirmed that acylguanidine derivatives (the following formula I; any one of Z 1 , Z 2 , Z 3 , Z 4 and Z 5 is nitrogen atom, and the others are carbon atoms) which have the characteristic structure in which the guanidine is bonded to one ring of the quinoline or isoquinoline via a carbonyl group, and a cyclic group is bonded to the other ring, exhibit potent 5-HT 5A receptor modulating actions and excellent pharmacological actions based on the 5-HT 5A receptor modulating action, and thus can be excellent agents for preventing or treating dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder. Thus, the present invention has been completed.

  提供一个基于调节5-HT5A受体的作用，用于预防或治疗痴呆、精神分裂症等的优秀药剂。[解决方案]确认了酰脒衍生物（以下公式I；Z1、Z2、Z3、Z4和Z5中的任何一个为氮原子，其余为碳原子）具有特征性结构，其中脒基通过羰基与喹啉或异喹啉的一个环连接，并且另一个环连接有环状基团，展现出强大的5-HT5A受体调节作用和基于5-HT5A受体调节作用的优秀药理作用，因此可作为预防或治疗痴呆、精神分裂症、双相情感障碍或注意力缺陷多动障碍的优秀药剂。因此，完成了本发明。
• SUBSTITUTED ACYLGUANIDINE DERIVATIVES (AS AMENDED)
  申请人：Kinoyama Isao

  公开号：US20120041036A1

  公开（公告）日：2012-02-16

  An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on serotonin 5-HT 5A receptor modulating action. It was discovered that acylguanidine derivatives, in which the guanidine is bonded to one ring of a naphthalene via a carbonyl group and a cyclic group is bonded to the other ring thereof, exhibit potent the 5-HT 5A receptor modulating action and excellent pharmacological actions based on the action. The present invention is useful as an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder or attention deficit hyperactivity disorder.

  本发明的目的是提供一种基于血清素5-HT5A受体调节作用的用于治疗或预防痴呆症、精神分裂症的优良药剂。发现酰基胍衍生物，其中胍基通过一个羰基与萘的一个环相结合，另一个环上结合有一个环状基团，表现出强效的5-HT5A受体调节作用和基于该作用的优良药理作用。本发明可用作治疗或预防痴呆症、精神分裂症、躁郁症或注意力缺陷多动障碍的优良药剂。
• ACYLGUANIDINE DERIVATIVES
  申请人：Kinoyama Isao

  公开号：US20110306621A1

  公开（公告）日：2011-12-15

  An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on a serotonin 5-HT 5A receptor modulating action. It was confirmed that acylguanidine derivatives, which has the characteristic structure in which the guanidine is bonded to one ring of a naphthalene via a carbonyl group and a cyclic group is bonded to the other ring thereof, exhibit potent 5-HT 5A receptor modulating action and excellent pharmacological action based on the action. The present invention is useful as an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder or attention deficit hyperactivity disorder.

  本发明的目的是提供一种基于5-羟色胺5-HT5A受体调节作用的治疗或预防痴呆症、精神分裂症的优良药剂。经确认，酰基胍衍生物具有特征结构，其中胍基通过羰基和环状基团与萘的一个环结合，另一个环上结合环状基团，表现出强效的5-HT5A受体调节作用和优良的药理作用。本发明可用作治疗或预防痴呆症、精神分裂症、双相障碍或注意力缺陷多动障碍的优良药剂。
• INCLUSION COMPLEX CONTAINING EPOXY RESIN COMPOSITION FOR SEMICONDUCTOR ENCAPSULATION
  申请人：Ono Kazuo

  公开号：US20100179250A1

  公开（公告）日：2010-07-15

  It is to improve the storage stability of a sealant, to retain the flowability of the sealant when sealing, and to achieve an effective curing rate of the sealant by heating to be applicable as a sealant for delicate semiconductors. It is an epoxy resin composition for sealing a semiconductor, comprising the following component (A) and component (B). (A) an epoxy resin, (B) a clathrate complex comprising (b1) an aromatic carboxylic acid compound, and (b2) at least one imidazole compound represented by formula (II) (wherein R 2 represents a hydrogen atom, etc.; R 3 to R 5 represent a hydrogen atom, etc.).

  这是为了改善密封剂的储存稳定性，保持密封时密封剂的流动性，并通过加热实现密封剂的有效固化速率，以适用于精细半导体的密封剂。它是一种用于密封半导体的环氧树脂组合物，包括以下组分（A）和组分（B）。（A）环氧树脂，（B）包括（b1）芳香羧酸化合物和（b2）至少一种由式（II）表示的咪唑化合物的笼形复合物（其中R2表示氢原子等；R3至R5表示氢原子等）。
• Radiation curable ink jet ink, comprising a polymerisation initiation sensitising dye
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP1657286A2

  公开（公告）日：2006-05-17

  The invention provides an inkjet recording ink which is curable by radiation irradiation containing a colorant, a polymerizable compound, and a polymerization initiation system, wherein the polymerization initiation system contains a sensitizing dye including one or more compounds selected from compounds represented by any one of formula (XIV) and formulae (XVI) to (XXVI) and a polymerization initiator; and a method of producing a planographic printing plate to obtain a hydrophobic image by ejecting the ink onto a hydrophilic support, and by irradiating radiation. Moreover, the invention provides an ink composition containing a sensitizing dye including a specific skeleton or a sensitizing dye represented by formula (I), a polymerizable compound, and a polymerization initiator; an inkjet recording method using the same; a printed material; a planographic printing plate; and a method of producing a planographic printing plate.

  本发明提供了一种可通过辐射辐照固化的喷墨记录墨水，该墨水含有着色剂、可聚合化合物和聚合引发体系，其中聚合引发体系含有敏化染料，包括一种或多种选自式(XIV)和式(XVI)至(XXVI)中任一种所代表的化合物和聚合引发剂的化合物；以及一种通过将墨水喷射到亲水性支持物上并通过辐射辐照来制作平版印刷板以获得疏水性图像的方法。此外，本发明还提供了一种墨水组合物，其中含有包括特定骨架的敏化染料或由式（I）表示的敏化染料、可聚合化合物和聚合引发剂；使用该墨水组合物的喷墨记录方法；印刷材料；平版印刷板；以及平版印刷板的制作方法。