3,6,9,12,15,18-六氧杂二十烷-1,20-二胺 | 76927-70-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3,6,9,12,15,18-六氧杂二十烷-1,20-二胺
• 英文名称: 1,20-Diamino-3,6,9,12,15,18-hexaoxaeicosane
• 英文别名: O,O'-bis(2-aminoethyl)pentaethylene glycol；PEODA7；Amino-PEG6-amine；2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
• CAS: 76927-70-3
• 化学式: C₁₄H₃₂N₂O₆
• 分子量: 324.418
• InChiKey: SEBZAAOSFDHURG-UHFFFAOYSA-N

物化性质

• 沸点：
  419.9±40.0 °C(Predicted)
• 密度：
  1.063±0.06 g/cm3(Predicted)
• 溶解度：
  溶于水、DMSO、DCM、DMF

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  22
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• 危险类别：
  8
• 危险性防范说明：
  P501,P264,P280,P303+P361+P353,P301+P330+P331,P363,P304+P340+P310,P305+P351+P338+P310,P405
• 危险品运输编号：
  2735
• 危险性描述：
  H314
• 包装等级：
  III

反应信息

• 作为反应物：
  描述：

  二碳酸二叔丁酯 、 3,6,9,12,15,18-六氧杂二十烷-1,20-二胺 以 二氯甲烷 为溶剂， 以76%的产率得到22-氨基-5,8,11,14,17,20-六氧杂-2-氮杂二十二酸 1,1-二甲基乙酯
  参考文献：
  名称：

  Oligo(ethylene glycol)-Based Thermosensitive Dendrimers and Their Tumor Accumulation and Penetration

  摘要：

  Dendrimers have several featured advantages over other nanomaterials as drug carriers, such as well-defined structure, specific low-nanometer size, and abundant peripheral derivable groups, etc. However, these advantages have not been fully exploited yet to optimize their biological performance, especially tumor penetration, which is a shortcoming of current nanomaterials. Here we show the syntheses of a new class of oligo(ethylene glycol) (OEG)-based thermosensitive dendrimers up to the fourth generation. Each dendrimer shows monodisperse structure. OEG/poly(ethylene glycol) (PEG) moieties with different precise lengths were introduced to the periphery of the fourth-generation dendrimer followed by an antitumor agent, gemcitabine (GEM). The biodistributions of the GEM-conjugated dendrimers were investigated by micro positron emission tomography and multispectral optoacoustic tomography imaging techniques and compared with that of GEM-conjugated poly(amidoamine) (PAMAM). The GEM-conjugated dendrimer with the longest peripheral PEG segments exhibited the most desirable tumor accumulation and penetration and thus had significantly higher antitumor activity than the GEM-conjugated PAMAM.

  DOI：

  10.1021/ja411457r
• 作为产物：
  描述：

  1,20-dichloro-3,6,9,12,15,18-hexaoxaeicosane 在 十六烷基三丁基溴化磷 、 一水合肼 作用下， 以 乙醇 、 甲苯 为溶剂， 生成 3,6,9,12,15,18-六氧杂二十烷-1,20-二胺
  参考文献：
  名称：

  Catalysis in aprotic solvents. Inter- and intramolecular hydrogen bonding complexation

  摘要：

  DOI：

  10.1021/jo00328a015

文献信息

• 一类含聚醚胺链段的阳离子活性染料及其制 备方法
  申请人：南京工业大学

  公开号：CN105694529B

  公开（公告）日：2017-06-23

  一类含聚醚胺链段的阳离子活性染料及其制备方法本发明涉及一类含聚醚胺链段的阳离子活性染料及其制备方法，属于染料化工和纺织印染领域。本发明所述含聚醚胺链段的阳离子活性染料的制备方法为：选用含氨基蒽醌结构化合物作为发色体，与1，3，5‑三氯均三嗪反应生成二氯均三嗪化合物，再与各种聚醚胺反应，生成含有一氯均三嗪基聚醚胺中间体；将环氧丙基季铵盐化合物滴加到一氯均三嗪基聚醚胺中间体中，生成含有聚醚胺链段阳离子活性染料。本发明所述的含聚醚胺链段阳离子活性染料结构新颖，制备条件温和，原料易得，污染少，产物收率和纯度高，可应用于棉织物染色的无盐染色使用。
• Crownphyrins: Metal‐Mediated Transformations of the Porphyrin‐Crown Ether Hybrids
  作者：Maksym Matviyishyn、Agata Białońska、Bartosz Szyszko

  DOI：10.1002/anie.202211671

  日期：2022.12.5

  Crownphyrins, hybrid systems forged from porphyrin and crown ether counterparts, were synthesized. The novel family of macrocycles serves as dynamic, conformationally flexible systems, able to undergo guest-induced, reversible expansion. The tunable character of their cavities allows for binding neutral and ionic guests.

  合成了由卟啉和冠醚对应物形成的杂化系统冠菲林。新型大环化合物家族作为动态的、构象灵活的系统，能够进行客体诱导的可逆膨胀。它们空腔的可调特性允许结合中性客体和离子客体。
• Synthesis and Structure of Upper-Rim 1,3-Alternate Tetraoxacalix[2]arene[2]triazine Azacrowns and Change of Cavity in Response to Fluoride Anion
  作者：Bao-Yong Hou、De-Xian Wang、Hai-Bo Yang、Qi-Yu Zheng、Mei-Xiang Wang

  DOI：10.1021/jo0706168

  日期：2007.7.1

  The upper-rim 1,3-alternate tetraoxacalix[2]arene[2]triazine azacrowns were constructed effectively by macrocyclic condensation reaction of diamines with dichlorinated tetraoxacalix[2]arene[2]triazine intermediates that were synthesized from the stepwise fragment coupling reactions of 3,5-dihydroxybenzoic acid esters with cyanuric chlorides. Because of the formation of conjugation of amino groups with triazine rings, tetraoxacalix[2]arene[2]triazine azacrowns existed in a mixture of syn- and anti-isomeric forms. Both fluorescence titration and H-1 NMR spectroscopic study showed that tetraoxacalix[2]arene[2]triazine azacrowns interacted with fluoride anion, leading to cavity changes of the host molecules.
• PROTEIN-DRUG CONJUGATES COMPRISING CAMPTOTHECIN ANALOGS AND METHODS OF USE THEREOF
  申请人：REGENERON PHARMACEUTICALS, INC.

  公开号：US20220072141A1

  公开（公告）日：2022-03-10

  Described herein are protein-drug conjugates and compositions thereof that are useful, for example, for target-specific delivery of therapeutic moieties, e.g., camptothecin analogs and/or derivatives. In certain embodiments, provided are specific and efficient methods for producing protein-drug constructs (e.g., antibody-drug conjugates) utilizing a combination of transglutaminase and 1,3-cycloaddition techniques. Camptothecin analogs, antibody-drug conjugates, and compositions which comprise glutaminyl-modified antibodies and camptothecin analog payloads and are provided.
• US3966766A
  申请人：——

  公开号：US3966766A

  公开（公告）日：1976-06-29