dimethyl 2-(4-methoxybenzoyl)cyclopropane-1,1-dicarboxylate | 1453810-98-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dimethyl 2-(4-methoxybenzoyl)cyclopropane-1,1-dicarboxylate
• 英文别名: Dimethyl 2-(4-methoxybenzoyl)cyclopropane-1,1-dicarboxylate
• CAS: 1453810-98-4
• 化学式: C₁₅H₁₆O₆
• 分子量: 292.288
• InChiKey: QVOZGMQSCXIFQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-bromo-1-(4-methoxyphenyl)propan-1-one 在 sodium methylate 、 potassium iodide 作用下， 以 甲醇 为溶剂， 反应 0.67h， 生成 dimethyl 2-(4-methoxybenzoyl)cyclopropane-1,1-dicarboxylate
  参考文献：
  名称：

  Anodic Cyclization of Dimethyl 2-(3-Oxo-3-arylpropyl) Malonates into the Corresponding Dimethyl 2-Aroylcyclopropane-1,1-dicarboxylates

  摘要：

  A variety of dimethyl 2-(3-oxo-3-arylpropyl)malonates were electrooxidized in methanol, in the presence of potassium iodide and a base or a neutral salt, to give the corresponding cyclized dimethyl 2-aroylcyclopropane-1,1-dicarboxylates in moderate to good yields. The reactions were carried out under extremely mild reaction conditions, in which the optimal amount of electrolytic current varied from 2.12-2.41 F.mol(-1) depending on the substrates. The reaction presumably proceeds via a two-electron oxidation process, in which iodide ions play an important role as the electron carrier between the anode and the substrate.

  DOI：

  10.1055/s-0033-1339198

文献信息

• Anodic Cyclization of Dimethyl 2-(3-Oxo-3-arylpropyl) Malonates into the Corresponding Dimethyl 2-Aroylcyclopropane-1,1-dicarboxylates
  作者：Mitsuhiro Okimoto、Haruki Yamamori、Kousuke Ohashi、Masayuki Hoshi、Takashi Yoshida

  DOI：10.1055/s-0033-1339198

  日期：——

  A variety of dimethyl 2-(3-oxo-3-arylpropyl)malonates were electrooxidized in methanol, in the presence of potassium iodide and a base or a neutral salt, to give the corresponding cyclized dimethyl 2-aroylcyclopropane-1,1-dicarboxylates in moderate to good yields. The reactions were carried out under extremely mild reaction conditions, in which the optimal amount of electrolytic current varied from 2.12-2.41 F.mol(-1) depending on the substrates. The reaction presumably proceeds via a two-electron oxidation process, in which iodide ions play an important role as the electron carrier between the anode and the substrate.