1-(furan-2-yl)-2-methylbut-3-yn-2-ol | 1196873-51-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(furan-2-yl)-2-methylbut-3-yn-2-ol
• 英文别名: 1-(Furan-2-yl)-2-methylbut-3-yn-2-ol
• CAS: 1196873-51-4
• 化学式: C₉H₁₀O₂
• 分子量: 150.177
• InChiKey: NJDZEUIEBBHNBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(furan-2-yl)-2-methylbut-3-yn-2-ol 在 三苯基膦双(三氟甲磺酰亚胺)金 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以48%的产率得到6-甲基苯并呋喃
  参考文献：
  名称：

  Gold catalysis: benzanellation versus alkylidenecyclopentenone synthesis

  摘要：

  A series of different furan-yn-ols were prepared by a three-step sequence. Their reaction with Gagosz's catalyst Ph3PAuNTf2 depends strongly on the substitution pattern of the Substrate and the quality of the leaving group. Benzofurans, alkylidenecyclopentenones or Meyer-Schuster type products can be obtained. Improving the leaving group quality leads to the preferred formation of benzofurans. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.08.074
• 作为产物：
  描述：

  2-呋喃基乙酮 、 Ethynylmagnesium chloride 以 四氢呋喃 、 甲苯 为溶剂， 反应 1.0h， 以43%的产率得到1-(furan-2-yl)-2-methylbut-3-yn-2-ol
  参考文献：
  名称：

  Gold catalysis: benzanellation versus alkylidenecyclopentenone synthesis

  摘要：

  A series of different furan-yn-ols were prepared by a three-step sequence. Their reaction with Gagosz's catalyst Ph3PAuNTf2 depends strongly on the substitution pattern of the Substrate and the quality of the leaving group. Benzofurans, alkylidenecyclopentenones or Meyer-Schuster type products can be obtained. Improving the leaving group quality leads to the preferred formation of benzofurans. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.08.074

文献信息

• Gold catalysis: benzanellation versus alkylidenecyclopentenone synthesis
  作者：A. Stephen K. Hashmi、Michael Wölfle

  DOI：10.1016/j.tet.2009.08.074

  日期：2009.10

  A series of different furan-yn-ols were prepared by a three-step sequence. Their reaction with Gagosz's catalyst Ph3PAuNTf2 depends strongly on the substitution pattern of the Substrate and the quality of the leaving group. Benzofurans, alkylidenecyclopentenones or Meyer-Schuster type products can be obtained. Improving the leaving group quality leads to the preferred formation of benzofurans. (C) 2009 Elsevier Ltd. All rights reserved.