[(2R,3S,4S,5R,6R)-3-benzoyloxy-4,5-bis(naphthalen-2-ylmethoxy)-6-(2,2,2-trichloroethanimidoyl)oxyoxan-2-yl]methyl benzoate | 1243247-58-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3S,4S,5R,6R)-3-benzoyloxy-4,5-bis(naphthalen-2-ylmethoxy)-6-(2,2,2-trichloroethanimidoyl)oxyoxan-2-yl]methyl benzoate
• CAS: 1243247-58-6
• 化学式: C₄₄H₃₆Cl₃NO₈
• 分子量: 813.131
• InChiKey: NSTUVYYXZQQIBS-XYHDOQJVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  56
• 可旋转键数：
  15
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  benzyl 2-acetamido-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-β-D-glucopyranoside 、 [(2R,3S,4S,5R,6R)-3-benzoyloxy-4,5-bis(naphthalen-2-ylmethoxy)-6-(2,2,2-trichloroethanimidoyl)oxyoxan-2-yl]methyl benzoate 在 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 以74%的产率得到
  参考文献：
  名称：

  Novel galactosyl donor with 2-naphthylmethyl (NAP) as the non-participating group at C-2 position: efficient synthesis of α-galactosyl ceramide

  摘要：

  Piedommant alpha-linked products can be generated in glycosylation involving galactosyl trichloroacetimiclate donors with 2-naphthylmethyl (NAP)as the non-participating group at C-2 position The above-mentioned donor was successfully utilized for the synthesis of alpha-galactosyl ceiamide. (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetlet.2010.06.071
• 作为产物：
  描述：

  、 三氯乙腈 在 N-溴代丁二酰亚胺(NBS) 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 丙酮 、 二氯甲烷 为溶剂， 反应 2.5h， 生成 [(2R,3S,4S,5R,6R)-3-benzoyloxy-4,5-bis(naphthalen-2-ylmethoxy)-6-(2,2,2-trichloroethanimidoyl)oxyoxan-2-yl]methyl benzoate
  参考文献：
  名称：

  Novel galactosyl donor with 2-naphthylmethyl (NAP) as the non-participating group at C-2 position: efficient synthesis of α-galactosyl ceramide

  摘要：

  Piedommant alpha-linked products can be generated in glycosylation involving galactosyl trichloroacetimiclate donors with 2-naphthylmethyl (NAP)as the non-participating group at C-2 position The above-mentioned donor was successfully utilized for the synthesis of alpha-galactosyl ceiamide. (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetlet.2010.06.071

文献信息

• Novel galactosyl donor with 2-naphthylmethyl (NAP) as the non-participating group at C-2 position: efficient synthesis of α-galactosyl ceramide
  作者：Sirajud D. Khaja、Vipin Kumar、Misbah Ahmad、Jun Xue、Khushi L. Matta

  DOI：10.1016/j.tetlet.2010.06.071

  日期：2010.8

  Piedommant alpha-linked products can be generated in glycosylation involving galactosyl trichloroacetimiclate donors with 2-naphthylmethyl (NAP)as the non-participating group at C-2 position The above-mentioned donor was successfully utilized for the synthesis of alpha-galactosyl ceiamide. (C) 2010 Elsevier Ltd All rights reserved