N-(5-oxo-pentyl)-acetamide | 4383-64-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(5-oxo-pentyl)-acetamide
• 英文别名: N-(5-Oxo-pentyl)-acetamid；5-Acetylamino-valeraldehyd；delta-Acetamidovaleraldehyde；N-(5-oxopentyl)acetamide
• CAS: 4383-64-6
• 化学式: C₇H₁₃NO₂
• mdl: MFCD17170678
• 分子量: 143.186
• InChiKey: CMKXYMURJCKXEU-UHFFFAOYSA-N

物化性质

• 沸点：
  180 °C(Press: 1 Torr)
• 密度：
  0.971±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(5-hydroxypentyl)acetamide 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 N-(5-oxo-pentyl)-acetamide
  参考文献：
  名称：

  Koishi; Imoto, Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1952, vol. 55, p. 648

  摘要：

  DOI：

文献信息

• METHODS AND MATERIALS FOR BIOSYNTHESIZING MULTIFUNCTIONAL, MULTIVARIATE MOLECULES VIA CARBON CHAIN MODIFICATION
  申请人：INVISTA NORTH AMERICA S.A.R.L.

  公开号：US20180023103A1

  公开（公告）日：2018-01-25

  This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation. The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.

  本文档描述了在体外或在重组宿主中通过形成选择自羧基、胺基、甲酰基和羟基中的两个末端功能基团在具有奇数碳原子数量的脂肪碳链骨架中合成的具有双功能产品的生化途径，或其盐或衍生物，该脂肪碳链骨架是通过从（i）乙酰辅酶A和丙二酰辅酶A经过一个或多个甲酯屏蔽的碳链延长循环或（ii）丙二酰-[acp] 经过一个或多个甲酯屏蔽的碳链延长循环合成的奇数碳原子。本文中描述的生化途径、代谢工程和培养策略依赖于接受甲酯屏蔽脂肪碳链骨架并在一个或多个甲酯屏蔽的碳链延长循环之后至少保持甲酯屏蔽以进行至少一个进一步的酶催化步骤的酶或同源体。
• Methods and materials for biosynthesizing multifunctional, multivariate molecules via carbon chain modification
  申请人：INVISTA NORTH AMERICA S.A.R.L.

  公开号：US10801046B2

  公开（公告）日：2020-10-13

  This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation. The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.

  本文件描述了在体外或重组宿主中生产具有奇数个碳原子的双官能团产物或其盐或衍生物的生化途径，其方法是在具有奇数个碳原子的脂肪族碳链骨架上形成两个末端官能团，这两个末端官能团选自羧基、胺、甲酰基和羟基、(i) 乙酰-CoA 和丙二酰-CoA 通过一次或多次循环的甲酯屏蔽碳链伸长或 (ii) 丙二酰-[acp]通过一次或多次循环的甲酯屏蔽碳链伸长合成的具有奇数个碳原子的脂肪族碳链骨架中的两个末端官能团。本文所述的生化途径和代谢工程及培养策略依赖于酶或同源物接受甲酯屏蔽的脂肪族碳链骨架，并在一个或多个甲酯屏蔽碳链伸长循环后维持甲酯屏蔽至少一个进一步的酶步骤。
• PROCESS FOR PRODUCING GLUTARATE AND GLUTARIC ACID METHYL ESTER
  申请人：Invista Technologies S.à r.l.

  公开号：EP3155111A1

  公开（公告）日：2017-04-19
• METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS
  申请人：Invista Technologies S.à.r.l.

  公开号：EP3155107A1

  公开（公告）日：2017-04-19
• NUCLEIC ACIDS ENCODING IMPROVED TRANSAMINASE PROTEINS
  申请人：Bayer Aktiengesellschaft

  公开号：EP3830252A1

  公开（公告）日：2021-06-09