trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran | 134186-90-6
中文名称
——
中文别名
——
英文名称
trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran
英文别名
(-)-trans-(2S,5S)-2-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran；trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran；(-)-trans-(2S,5S)-2-[3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran；(2S,5S)-2-(3-methylsulfonyl-5-phenylmethoxy-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)oxolane
CAS
134186-90-6
化学式
C30H36O8S
mdl
——
分子量
556.677
InChiKey
OTISLSMPVRENDE-ZEQRLZLVSA-N
BEILSTEIN
——
EINECS
——
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
物化性质
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沸点：707.4±60.0 °C(Predicted)
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密度：1.200±0.06 g/cm3(Predicted)
计算性质
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辛醇/水分配系数(LogP)：5.1
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重原子数：39
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可旋转键数：12
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环数：4.0
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sp3杂化的碳原子比例：0.4
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拓扑面积：97.9
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氢给体数：0
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氢受体数：8
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 —— (-)-(1S)-1-hydroxy-1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butan-4-one 134169-13-4 C30H36O9S 572.676 —— 1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione 134169-12-3 C30H34O9S 570.661 —— 1-<3-(methylthio)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione 134169-11-2 C30H34O7S 538.662 —— 3-(methylthio)-4-n-propoxy-5-(benzyloxy)benzaldehyde 133239-56-2 C18H20O3S 316.421 -
下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— (-)-trans-(2S,5S)-2-<3-<((2R,S)-2-hydroxypropyl)-sulfonyl>-4-n-propyl-5-(benzyloxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 134169-28-1 C32H40O9S 600.73 —— (-)-trans-(2S,5S)-2-<3-<((2R)-2-hydroxypropyl)sulfonyl>-4-n-propoxy-5-(benzyloxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 134236-03-6 C32H40O9S 600.73 —— (-)-trans-(2S,5S)-2-<3-<((2S)-2-hydroxypropyl)sulfonyl>-4-n-propoxy-5-(benzyloxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 134236-02-5 C32H40O9S 600.73 —— (-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-(benzyloxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 134235-99-7 C32H38O9S 598.714 1-[3-(3-羟基丙氧基)-2-丙氧基-5-[(2S,5S)-5-(3,4,5-三甲氧基苯基)四氢呋喃-2-基]苯基]磺酰基丙烷-2-酮 (-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-(3-hydroxypropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 140705-10-8 C28H38O10S 566.67 —— (-)-trans-(2S,5S)-2-<3-<((2S)-2-hydroxypropyl)sulfonyl>-4-n-propoxy-5-(3-hydroxypropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 134169-30-5 C28H40O10S 568.686 —— (-)-trans-(2S,5S)-2-<3-<((2R)-2-hydroxypropyl)sulfonyl>-4-n-propoxy-5-(3-hydroxypropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 134236-06-9 C28H40O10S 568.686 —— (-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-hydroxyphenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 134236-00-3 C25H32O9S 508.59 —— (-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-(3-bromopropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 143395-24-8 C28H37BrO9S 629.566 —— 3-[(2R)-2-hydroxypropyl]sulfonyl-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenol 134169-29-2 C25H34O9S 510.606 —— 3-[(2S)-2-hydroxypropyl]sulfonyl-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenol 134236-04-7 C25H34O9S 510.606 —— (-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-<3-(phosphonooxy)propoxy>phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 134236-08-1 C28H39O13PS 646.65 —— (-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-<3-(1-morpholino)-n-propoxy>phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 134186-92-8 C32H45NO10S 635.776 —— [(2R)-1-[3-phenylmethoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylpropan-2-yl] (2R)-2-methoxy-2-phenylacetate 143346-10-5 C41H48O11S 748.892 —— [(2S)-1-[3-phenylmethoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylpropan-2-yl] (2R)-2-methoxy-2-phenylacetate 143395-27-1 C41H48O11S 748.892 —— (-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-<3-(1-imidazoyl)-n-propoxy>phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 134237-19-7 C31H40N2O9S 616.733 —— (-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-<<<3-(dibenzyloxy)phosphoryl>oxy>propoxy>phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 134169-24-7 C42H51O13PS 826.899 - 1
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反应信息
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作为反应物：描述：trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran 在 palladium on activated charcoal 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 氢气 、 N,N'-二环己基碳二亚胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 、 环己烷 、 乙酸乙酯 为溶剂， 反应 6.17h， 生成 3-[(2R)-2-hydroxypropyl]sulfonyl-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenol参考文献：