4,5-diphenyl-1H-imidazole-2-carboxamide | 41270-78-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5-diphenyl-1H-imidazole-2-carboxamide
• 英文别名: 4,5-diphenyl-1H-imidazole-2-carboxylic acid amide；4,5-Diphenylimidazol-2-carbonamid
• CAS: 41270-78-4
• 化学式: C₁₆H₁₃N₃O
• 分子量: 263.299
• InChiKey: FYFZEMZARMRJBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.8
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基丙二酰胺 、 benzil phenylhydrazone 反应 72.0h， 以71%的产率得到4,5-diphenyl-1H-imidazole-2-carboxamide
  参考文献：
  名称：

  A Convenient and New One-Step Synthesis of 1H-Imidazole-2-carboxamides

  摘要：

  1,2-Diketone monophenylhydrazones (2) reacted with aminomalonamide in 1-methyl-2-pyrrolidinone to provide 1-H-imidazole-2-carboxamides (4). The condensation of 1-(4-pyridinyl)-2-propanone with phenyldiazonium chloride gave 1-phenylhydrazono-1-(4-pyridinyl)-2-propanone (2a). 4-Methyl-5-(4-pyridinyl)-1H-imidazole-2-carboxamide (4a) was converted to the corresponding nitrile (5a) by the action of phosphorous oxychloride.

  DOI：

  10.3987/com-92-6169

文献信息

• USE OF EFFECTORS OF GLUTAMINYL AND GLUTAMATE CYCLASES
  申请人：Probiodrug AG

  公开号：EP1675578A2

  公开（公告）日：2006-07-05
• [EN] USE OF EFFECTORS OF GLUTAMINYL AND GLUTAMATE CYCLASES<br/>[FR] UTILISATION D'EFFECTEURS DE CYCLASES DU GLUTAMINYLE ET DU GLUTAMATE
  申请人：PROBIODRUG AG

  公开号：WO2005039548A2

  公开（公告）日：2005-05-06

  The present invention provides novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC and the use of such effectors and pharmaceutical compositions comprising such effectors for the treatment of diseases that can be treated by modulation of QC-activity, e.g. diseases selected from the group consisting of duodenal cancer with or w/o Heliobacter pylori infections, colorectal cancer, Zolliger-Ellison syndrome, Familial British Dementia and Familial Danish Dementia.
• A Convenient and New One-Step Synthesis of 1H-Imidazole-2-carboxamides
  作者：Baldev Singh

  DOI：10.3987/com-92-6169

  日期：——

  1,2-Diketone monophenylhydrazones (2) reacted with aminomalonamide in 1-methyl-2-pyrrolidinone to provide 1-H-imidazole-2-carboxamides (4). The condensation of 1-(4-pyridinyl)-2-propanone with phenyldiazonium chloride gave 1-phenylhydrazono-1-(4-pyridinyl)-2-propanone (2a). 4-Methyl-5-(4-pyridinyl)-1H-imidazole-2-carboxamide (4a) was converted to the corresponding nitrile (5a) by the action of phosphorous oxychloride.