1-Imidazol-1-yl-2-(4-methoxyphenoxy)ethanone | 1267674-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Imidazol-1-yl-2-(4-methoxyphenoxy)ethanone
• 英文别名: 1-imidazol-1-yl-2-(4-methoxyphenoxy)ethanone
• CAS: 1267674-39-4
• 化学式: C₁₂H₁₂N₂O₃
• 分子量: 232.239
• InChiKey: GZWKPKIWJJSUQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  53.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Imidazol-1-yl-2-(4-methoxyphenoxy)ethanone 在 吡啶 、 盐酸 、 4-二甲氨基吡啶 、 水 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 1.0h， 生成 tert-butyl 4-(4-methoxyphenoxy)-3-oxobutanoate
  参考文献：
  名称：

  A new diversity oriented and metal-free approach to highly functionalized 3H-pyrimidin-4-ones

  摘要：

  本文介绍了一种新的3H-嘧啶-4-酮合成方法，其特点是具有四组不同的修饰。该策略基于对易于获得的α-取代β-酮酯进行合成精细加工，随后将其转化为相应的酰基烯胺，进而环合形成6H-1,3-噁嗪-6-酮。这些活泼的中间体再通过与适当的伯胺处理，干净利落地转化为高度功能化的嘧啶酮。整个合成序列无需使用任何金属媒介或催化剂。

  DOI：

  10.1039/c0ob00978d
• 作为产物：
  描述：

  4-甲氧基苯酚 在 lithium hydroxide monohydrate 、 potassium carbonate 作用下， 以 甲醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 27.0h， 生成 1-Imidazol-1-yl-2-(4-methoxyphenoxy)ethanone
  参考文献：
  名称：

  In silico and pharmacological screenings identify novel serine racemase inhibitors

  摘要：

  D-Serine is a coagonist of the N-methyl-D-aspartate (NMDA)-type glutamate receptor and its biosynthesis is catalyzed by serine racemase (SR). The overactivation of the NMDA receptor has been implicated in the development of neurodegenerative diseases, strokes, and epileptic seizures, thus, the inhibitors of SR have potential against these pathological states. Here, we have developed novel inhibitors of SR by in silico screening and in vitro enzyme assay. The newly developed inhibitors have lower IC50 value comparing with that of malonate, one of the standard SR inhibitor. The structural features of novel inhibitors suggest the importance of central amide structure having a phenoxy substituent in their structure for the SR inhibitory activity. The present findings suggest the importance and rational development of new drugs for diseases of NMDAR overactivation.

  DOI：

  10.1016/j.bmcl.2014.07.003

文献信息

• Ketoreductase catalyzed stereoselective bioreduction of α-nitro ketones
  作者：Zexu Wang、Xiaofan Wu、Zhining Li、Zedu Huang、Fener Chen

  DOI：10.1039/c9ob00051h

  日期：——

  the best of our knowledge, KRED-mediated reduction of class II α-nitro ketones (1-aryloxy-3-nitro-2-propanone (4)) is unprecedented. Select β-nitro alcohols, including the synthetic intermediates of bioactive molecules (R)-tembamide, (S)-tembamide, (S)-moprolol, (S)-toliprolol and (S)-propanolol, were stereoselectively synthesized in preparative scale with 42% to 90% isolated yields, showcasing the

  我们在这里报告由酮还原酶（KREDs）催化的α-硝基酮的立体选择性生物还原，该序列具有众所周知的序列。YGL039w和RasADH / SyADH能够还原23种I类底物（1-芳基-2-硝基-1-乙酮（1））和十种II类底物（1-芳氧基-3-硝基-2-丙酮（4））提供相应的β-硝基醇的两种对映异构体，在大多数情况下可实现良好至优异的转化率（最高> 99％）和对映选择性（最高> 99％ee）。据我们所知，KRED介导的II类α-硝基酮（1-芳氧基-3-硝基-2-丙酮（4））的还原是前所未有的。选择β-硝基醇，包括生物活性分子的合成中间体（R）-氨甲酰胺，（S）-氨甲酰胺，（S）-异丙醇，（S）-甲苯酚和（S）-丙醇 以制备规模进行立体选择性合成，分离产率为42％至90％，这表明了我们开发的系统在有机合成中的实际应用潜力。最后，通过全细胞催化展示了使用具有已知序列的KRED的优势，其中在空间中生
• A new diversity oriented and metal-free approach to highly functionalized 3H-pyrimidin-4-ones
  作者：Renata Riva、Luca Banfi、Andrea Basso、Paola Zito

  DOI：10.1039/c0ob00978d

  日期：——

  A new synthesis of 3H-pyrimidin-4-ones, characterized by four different sets of decorations, is presented. The strategy is based on the synthetic elaboration of readily available α-substituted β-ketoesters that, upon transformation into the corresponding acyl enamines, have been cyclized to give 6H-1,3-oxazin-6-ones. These reactive intermediates have been in turn cleanly converted into highly functionalized pyirimidinones, by treatment with an appropriate primary amine. The whole sequence does not need the use of any metal mediator or catalyst.

  本文介绍了一种新的3H-嘧啶-4-酮合成方法，其特点是具有四组不同的修饰。该策略基于对易于获得的α-取代β-酮酯进行合成精细加工，随后将其转化为相应的酰基烯胺，进而环合形成6H-1,3-噁嗪-6-酮。这些活泼的中间体再通过与适当的伯胺处理，干净利落地转化为高度功能化的嘧啶酮。整个合成序列无需使用任何金属媒介或催化剂。
• In silico and pharmacological screenings identify novel serine racemase inhibitors
  作者：Hisashi Mori、Ryogo Wada、Jie Li、Tetsuya Ishimoto、Mineyuki Mizuguchi、Takayuki Obita、Hiroaki Gouda、Shuichi Hirono、Naoki Toyooka

  DOI：10.1016/j.bmcl.2014.07.003

  日期：2014.8

  D-Serine is a coagonist of the N-methyl-D-aspartate (NMDA)-type glutamate receptor and its biosynthesis is catalyzed by serine racemase (SR). The overactivation of the NMDA receptor has been implicated in the development of neurodegenerative diseases, strokes, and epileptic seizures, thus, the inhibitors of SR have potential against these pathological states. Here, we have developed novel inhibitors of SR by in silico screening and in vitro enzyme assay. The newly developed inhibitors have lower IC50 value comparing with that of malonate, one of the standard SR inhibitor. The structural features of novel inhibitors suggest the importance of central amide structure having a phenoxy substituent in their structure for the SR inhibitory activity. The present findings suggest the importance and rational development of new drugs for diseases of NMDAR overactivation.