2-acetyl-4,5-diisopropylfuran | 339547-04-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-acetyl-4,5-diisopropylfuran
• 英文别名: 1-[4,5-di(propan-2-yl)furan-2-yl]ethanone
• CAS: 339547-04-5
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: YFFUDXZPBDABLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-乙酰基呋喃 以34%的产率得到
  参考文献：
  名称：

  VALENTA M.; KOUBEK I., COLLECT. CZECH. CHEM. COMMUNS , 1976, 41, NO 1, 78-83

  摘要：

  DOI：

文献信息

• 5-MEMBERED HETEROCYCLIC COMPOUND
  申请人：Muratake Hideaki

  公开号：US20110213156A1

  公开（公告）日：2011-09-01

  A compound represented by the following general formula (I): [wherein R 1 and R 2 represent an alkyl group, X represents —S—, —O— or —NH—, Y represents C or N, R 3 represents hydrogen atom or a C 1-10 alkyl group, Z represents —CO—N(R 5 )— (R 5 represents hydrogen atom or a C 1-6 alkyl group) or —C(R 6 )═C(R 7 )—CO—NH— (R 6 and R 7 represent hydrogen atom or a C 1-6 alkyl group), Ar represents an aryldiyl group or a heteroaryldiyl group, and R 4 represents —COOH, —OCH 2 —COOH, —CH 2 —COOH, or —CH 2 —CH 2 —COOH], which has a retinoid action and is useful as an active ingredient of a medicament.

  以下是通用式(I)所代表的化合物：[其中R1和R2代表烷基，X代表—S—、—O—或—NH—，Y代表C或N，R3代表氢原子或C1-10烷基，Z代表—CO—N(R5)—(R5代表氢原子或C1-6烷基)或—C(R6)═C(R7)—CO—NH—(R6和R7代表氢原子或C1-6烷基)，Ar代表芳基二基团或杂芳基二基团，R4代表—COOH、—OCH2—COOH、—CH2—COOH或—CH2—CH2—COOH]，具有视黄醇作用，是药物的有效成分。
• 5-membered heterocyclic compound
  申请人：Muratake Hideaki

  公开号：US08722730B2

  公开（公告）日：2014-05-13

  A compound represented by the following general formula (I): [wherein R1 and R2 represent an alkyl group, X represents —S—, —O— or —NH—, Y represents C or N, R3 represents hydrogen atom or a C1-10 alkyl group, Z represents —CO—N(R5)— (R5 represents hydrogen atom or a C1-6 alkyl group) or —C(R6)═C(R7)—CO—NH— (R6 and R7 represent hydrogen atom or a C1-6 alkyl group), Ar represents an aryldiyl group or a heteroaryldiyl group, and R4 represents —COOH, —OCH2—COOH, —CH2—COOH, or —CH2—CH2—COOH], which has a retinoid action and is useful as an active ingredient of a medicament.

  以下是通式（I）所代表的化合物：[其中R1和R2代表烷基，X代表—S—，—O—或—NH—，Y代表C或N，R3代表氢原子或C1-10烷基，Z代表—CO—N（R5）—（R5代表氢原子或C1-6烷基）或—C（R6）═C（R7）—CO—NH—（R6和R7代表氢原子或C1-6烷基），Ar代表芳基二基团或杂芳基二基团，R4代表—COOH，—OCH2—COOH，—CH2—COOH或—CH2—CH2—COOH]，其具有视黄醇作用，并可用作药物的活性成分。
• FIVE-MEMBERED HETEROCYCLIC COMPOUND
  申请人：Research Foundation Itsuu Laboratory

  公开号：EP2189445A1

  公开（公告）日：2010-05-26

  A compound represented by the following general formula (I): [wherein R1 and R2 represent an alkyl group, X represents -S-, -O- or -NH-, Y represents C or N, R3 represents hydrogen atom or a C1-10 alkyl group, Z represents CO-N(R5)- (R5 represents hydrogen atom or a C1-6 alkyl group) or -C(R6)=C(R7)-CO-NH-(R6 and R7 represent hydrogen atom or a C1-6 alkyl group), Ar represents an aryldiyl group or a heteroaryldiyl group, and R4 represents -COOH, -OCH2-COOH, -CH2-COOH, or -CH2-CH2-COOH], which has a retinoid action and is useful as an active ingredient of a medicament.

  由以下通式 (I) 代表的化合物： [其中 R1 和 R2 代表烷基，X 代表-S-、-O-或-NH-，Y 代表 C 或 N，R3 代表氢原子或 C1-10 烷基，Z 代表 CO-N(R5)-（R5 代表氢原子或 C1-6 烷基）或-C(R6)=C(R7)-CO-NH-（R6 和 R7 代表氢原子或 C1-6 烷基）、Ar 代表芳基二烷基或杂芳基二烷基，R4 代表-COOH、-OCH2-COOH、-CH2-COOH 或 -CH2-CH2-COOH]，具有维甲酸作用，可用作药物的活性成分。
• EP2189445
  申请人：——

  公开号：——

  公开（公告）日：——
• US8722730B2
  申请人：——

  公开号：US8722730B2

  公开（公告）日：2014-05-13