(E)-ethyl 3-(2-chloro-4-nitro phenyl)acrylate | 198194-84-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-ethyl 3-(2-chloro-4-nitro phenyl)acrylate
• 英文别名: ethyl (E)-3-(2-chloro-4-nitrophenyl)prop-2-enoate
• CAS: 198194-84-2
• 化学式: C₁₁H₁₀ClNO₄
• 分子量: 255.658
• InChiKey: FZPBMOXGEPVPBA-GQCTYLIASA-N

物化性质

• 沸点：
  349.1±27.0 °C(Predicted)
• 密度：
  1.340±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2-氯-4硝基苄醇)甲醇 、 乙氧甲酰基亚甲基三苯基膦 在 aluminum (III) chloride 、 Oxone 作用下， 以 水 为溶剂， 反应 2.0h， 以93%的产率得到(E)-ethyl 3-(2-chloro-4-nitro phenyl)acrylate
  参考文献：
  名称：

  AlCl3-catalyzed oxidation of alcohol

  摘要：

  The metalloid salt AlCl3, applied as catalyst for the oxidation of alcohol was presented. In water media, variety of alcohols, including inactive aliphatic alcohols, could be converted into corresponding carbonyl compounds with excellent conversion and selectivity. Especially, this green reaction system also exemplifies advances toward the domino synthesis alkenes in good yields (>52%) and perfect purity (>99%), and the reaction gave preferentially the E-isomer. The obvious advantages of the present protocol include green reaction media, wide functional group tolerance, convenient product isolation, as well as grams reaction scale. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.09.035

文献信息

• US7888363B2
  申请人：——

  公开号：US7888363B2

  公开（公告）日：2011-02-15
• AlCl3-catalyzed oxidation of alcohol
  作者：Shang Wu、Hengchang Ma、Ziqiang Lei

  DOI：10.1016/j.tet.2010.09.035

  日期：2010.11

  The metalloid salt AlCl3, applied as catalyst for the oxidation of alcohol was presented. In water media, variety of alcohols, including inactive aliphatic alcohols, could be converted into corresponding carbonyl compounds with excellent conversion and selectivity. Especially, this green reaction system also exemplifies advances toward the domino synthesis alkenes in good yields (>52%) and perfect purity (>99%), and the reaction gave preferentially the E-isomer. The obvious advantages of the present protocol include green reaction media, wide functional group tolerance, convenient product isolation, as well as grams reaction scale. (C) 2010 Elsevier Ltd. All rights reserved.