1-(4-fluorophenyl)-2-phenoxy-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanone | 1574666-28-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-fluorophenyl)-2-phenoxy-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanone
• 英文别名: 1-(4-Fluorophenyl)-2-phenoxy-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxyethanone；1-(4-fluorophenyl)-2-phenoxy-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxyethanone
• CAS: 1574666-28-6
• 化学式: C₂₃H₂₈FNO₃
• 分子量: 385.479
• InChiKey: NUZSFGJVHPVOHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,2,6,6-四甲基哌啶氧化物 、 1-(4-氟苯基)-2-苯氧基乙酮 以 乙腈 为溶剂， 反应 24.0h， 以96%的产率得到1-(4-fluorophenyl)-2-phenoxy-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethanone
  参考文献：
  名称：

  铜用2,2,6,6-四甲基哌啶-1-氧基（TEMPO）催化酮的α-氨基氧化

  摘要：

  AbstractAn efficient copper‐catalyzed α‐aminoxylation of ketones with 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) is presented for the synthesis of 2‐aryloxy‐1‐aryl‐2‐(2,2,6,6‐tetramethylpiperidin‐1‐yloxy)ethanones in moderate to excellent yields. It is noteworthy that the copper/iron (Cu/Fe) catalyst can be recovered and reused several times with high catalytic reactivity.magnified image

  DOI：

  10.1002/adsc.201300630

文献信息

• Copper-Catalyzed α-Aminoxylation of Ketones with 2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO)
  作者：Ye-Xiang Xie、Ren-Jie Song、Yu Liu、Yan-Yun Liu、Jian-Nan Xiang、Jin-Heng Li

  DOI：10.1002/adsc.201300630

  日期：2013.11.25

  AbstractAn efficient copper‐catalyzed α‐aminoxylation of ketones with 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) is presented for the synthesis of 2‐aryloxy‐1‐aryl‐2‐(2,2,6,6‐tetramethylpiperidin‐1‐yloxy)ethanones in moderate to excellent yields. It is noteworthy that the copper/iron (Cu/Fe) catalyst can be recovered and reused several times with high catalytic reactivity.magnified image